Biography

Dr. Gurbani received his Ph.D in biotechnology from the Council of Scientific & Industrial Research (CSIR) -Institute of Toxicology Research, Lucknow and Jamia Hamdard University, New Delhi, India, with an emphasis on molecular mechanism of quinone-based DNA damage and repair. His work demonstrated quinone inhibition of ATPase domain movement during the catalytic cycle of topoisomerase IIα resulting in inhibition of DNA repair and loss of genomic integrity, which may result in clastogenicity and leukemia.

During his postdoctoral training (2012-2018) in Westover Lab, part of the Department of Radiation Oncology at UT Southwestern, Dr. Gurbani led experimental efforts toward the development of several reversible and irreversible inhibitors for different cancer-associated kinases serving as useful pharmacological probes. During this period, Dr. Gurbani also completed coursework in clinical pharmacology and drug development.

Dr. Gurbani was promoted to Instructor on February 1, 2019. With his expertise in X-ray crystallography, biochemistry, cancer biology, and structure-guided drug development, Dr. Deepak continues to develop lead compounds targeting other cancer-associated kinases for development of new targeted cancer therapies.

Research Interest

  • Cancer therapeutics: developing kinase inhibitors
  • Developing RAS inhibitors
  • DNA damage and repair
  • Protein: structure and function

Publications

Featured Publications LegendFeatured Publications

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
Hunter JC, Manandhar A, Carrasco MA, Gurbani D, Gondi S, Westover KD Mol. Cancer Res. 2015 Sep 13 9 1325-35
Development of small molecules targeting the pseudokinase Her3.
Lim SM, Xie T, Westover KD, Ficarro SB, Tae HS, Gurbani D, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS Bioorg. Med. Chem. Lett. 2015 Aug 25 16 3382-9
Discovery of type II inhibitors of TGFß-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).
Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS J. Med. Chem. 2015 Jan 58 1 183-96
Pharmacological targeting of the pseudokinase Her3.
Xie T, Lim SM, Westover KD, Dodge ME, Ercan D, Ficarro SB, Udayakumar D, Gurbani D, Tae HS, Riddle SM, Sim T, Marto JA, Jänne PA, Crews CM, Gray NS Nat. Chem. Biol. 2014 Dec 10 12 1006-12
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C.
Hunter JC, Gurbani D, Ficarro SB, Carrasco MA, Lim SM, Choi HG, Xie T, Marto JA, Chen Z, Gray NS, Westover KD Proc. Natl. Acad. Sci. U.S.A. 2014 Jun 111 24 8895-900
Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells.
Gurbani D, Bharti SK, Kumar A, Pandey AK, Ana GR, Verma A, Khan AH, Patel DK, Mudiam MK, Jain SK, Roy R, Dhawan A Int J Hyg Environ Health 2013 Aug 216 5 553-65
TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells.
Shukla RK, Kumar A, Gurbani D, Pandey AK, Singh S, Dhawan A Nanotoxicology 2013 Feb 7 1 48-60
In-vivo efficacy of compliant 3D nano-composite in critical-size bone defect repair: a six month preclinical study in rabbit.
Sagar N, Pandey AK, Gurbani D, Khan K, Singh D, Chaudhari BP, Soni VP, Chattopadhyay N, Dhawan A, Bellare JR PLoS ONE 2013 8 10 e77578
Mechanism of inhibition of the ATPase domain of human topoisomerase IIa by 1,4-benzoquinone, 1,2-naphthoquinone, 1,4-naphthoquinone, and 9,10-phenanthroquinone.
Gurbani D, Kukshal V, Laubenthal J, Kumar A, Pandey A, Tripathi S, Arora A, Jain SK, Ramachandran R, Anderson D, Dhawan A Toxicol. Sci. 2012 Apr 126 2 372-90
Interaction of C60 fullerene with the proteins involved in DNA mismatch repair pathway.
Gupta SK, Baweja L, Gurbani D, Pandey AK, Dhawan A J Biomed Nanotechnol 2011 Feb 7 1 179-80

Honors & Awards

  • PDA Travel Award, UT Southwestern Medical Center, Dallas, Texas, US
    (2015)
  • RCB-Young Investigator (RCB-YI) Award, Regional Centre for Biotechnology, India
    (2012)
  • International Travel Award, Department of Science & Technology, India
    (2011)
  • International Travel Award, Department of Science & Technology, India
    (2009)
  • Junior Research Fellowship in Life Sciences, Council of Scientific and Industrial Research, India
    (2006)
  • Junior Research Fellowship, Indian Council of Medical Research, India
    (2003)
  • Lectureship Award in Life Sciences, University Grants Commission, India
    (2002-2005)

Professional Associations/Affiliations

  • American Association for Cancer Research (2017)
  • American Association for the Advancement of Science (2017)
  • American Cancer Society Cancer Action Network (2017)
  • Radiation Research Society (2014)
  • Indian Nanoscience Society (2007)