Hasan Zaki, PhD is an Assistant Professor in the Department of Pathology. Dr. Zaki studies molecular mechanism of inflammatory disorders including inflammatory bowel disease, colorectal cancer, hepatocellular carcinoma, obesity, fatty liver disease, and metabolic syndrome.
Dr. Zaki earned his doctoral degree from Kumamoto University, Japan where he investigated the role of nitric oxide in host defense against bacterial infection and discovered that nitro-cyclic GMP, a nitrated nucleotide derivative, acts as a potential signal transduction molecule. For postdoctoral training, he moved to Dr. Thirumala-devi Kanneganti's laboratory at St. Jude Children’s Research Hospital, Memphis, TN. His postdoctoral studies were focused on understanding the role of NOD-like receptors (NLR), a group of cytosolic pathogen recognition receptor, in intestinal inflammatory disorders.
Research in Dr. Zaki’s lab aims to dissect signaling pathways regulated by NLRs and other pathogen sensors. He showed that NLRP3 and AIM2 are critical inflammasome activating sensors involved in maintaining intestinal homeostasis and healthy gut microbiota composition. He also demonstrated that several NLRs including NOD2 and NLRP12 play central roles in suppressing intestinal inflamamtion and colorectal cancer via downregualtion of inflammatory signaling pathways, such as NF-kB and MAPK. His laboratory also made seminal discovery that higher intake of dietary sugars predisposes and enhances pathogenesis of inflammatory bowel disease via modulaiton of gut microbiota composiiton. Ongoing studies in his laboratory is focused on understanding the complex interplay between innate iimmunity, diet, and gut microbiota in regulating intestinal homeostasis and inflammatory disorders including cancer.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Cell Signaling
- Diet and Metabolic Disorders
- Gastrointestinal Inflammation and Cancer
- Gut Microbiome
- Host Pathogen Interaction
- NOD-Like Receptors
- Role of inflammasomes in host defense against Citrobacter rodentium infection.
- Liu Z, Zaki MH, Vogel P, Gurung P, Finlay BB, Deng W, Lamkanfi M, Kanneganti TD J. Biol. Chem. 2012 May 287 20 16955-64
- Inflammasome is a central player in the induction of obesity and insulin resistance.
- Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D, Neale GA, Hooiveld GJ, Hijmans A, Vroegrijk I, van den Berg S, Romijn J, Rensen PC, Joosten LA, Netea MG, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2011 Sep 108 37 15324-9
- Inflammasomes and Intestinal Tumorigenesis.
- Zaki MH, Lamkanfi M, Kanneganti TD Drug Discov Today Dis Mech 2011 8 3-4 e71-e78
- IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation.
- Zaki MH, Vogel P, Body-Malapel M, Lamkanfi M, Kanneganti TD J. Immunol. 2010 Oct 185 8 4912-20
- Cytoprotective function of heme oxygenase 1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis.
- Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, Akaike T J. Immunol. 2009 Mar 182 6 3746-56
- Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis.
- Alam MS, Zaki MH, Sawa T, Islam S, Ahmed KA, Fujii S, Okamoto T, Akaike T Microbiol. Immunol. 2008 Apr 52 4 197-208
- Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection.
- Alam MS, Zaki MH, Yoshitake J, Akuta T, Ezaki T, Akaike T Microb. Pathog. 2006 Mar 40 3 116-25
- Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis.
- Akuta T, Zaki MH, Yoshitake J, Okamoto T, Akaike T Nitric Oxide 2006 Mar 14 2 101-8
- Nitric oxide-induced nitrative stress involved in microbial pathogenesis.
- Zaki MH, Akuta T, Akaike T J. Pharmacol. Sci. 2005 Jun 98 2 117-29
- Seroepidemiology of hepatitis B and delta virus infections in Bangladesh.
- Zaki H, Darmstadt GL, Baten A, Ahsan CR, Saha SK J. Trop. Pediatr. 2003 Dec 49 6 371-4
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)