Hasan Zaki, PhD is an Assistant Professor in the Department of Pathology. Dr. Zaki studies molecular mechanism of inflammatory disorders including inflammatory bowel disease, colorectal cancer, hepatocellular carcinoma, obesity, fatty liver disease, and metabolic syndrome.
Dr. Zaki earned his doctoral degree from Kumamoto University, Japan where he investigated the role of nitric oxide in host defense against bacterial infection and discovered that nitro-cyclic GMP, a nitrated nucleotide derivative, acts as a potential signal transduction molecule. For postdoctoral training, he moved to Dr. Thirumala-devi Kanneganti's laboratory at St. Jude Children’s Research Hospital, Memphis, TN. His postdoctoral studies were focused on understanding the role of NOD-like receptors (NLR), a group of cytosolic pathogen recognition receptor, in intestinal inflammatory disorders.
Research in Dr. Zaki’s lab aims to dissect signaling pathways regulated by NLRs and other pathogen sensors. He showed that NLRP3 and AIM2 are critical inflammasome activating sensors involved in maintaining intestinal homeostasis and healthy gut microbiota composition. He also demonstrated that several NLRs including NOD2 and NLRP12 play central roles in suppressing intestinal inflamamtion and colorectal cancer via downregualtion of inflammatory signaling pathways, such as NF-kB and MAPK. His laboratory also made seminal discovery that higher intake of dietary sugars predisposes and enhances pathogenesis of inflammatory bowel disease via modulaiton of gut microbiota composiiton. Ongoing studies in his laboratory is focused on understanding the complex interplay between innate iimmunity, diet, and gut microbiota in regulating intestinal homeostasis and inflammatory disorders including cancer.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Cell Signaling
- Diet and Metabolic Disorders
- Gastrointestinal Inflammation and Cancer
- Gut Microbiome
- Host Pathogen Interaction
- NOD-Like Receptors
- Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
- Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T Nat. Chem. Biol. 2007 Nov 3 11 727-35
- Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma.
- Khan S, Zaki H, Int J Mol Sci 2020 Jan 21 2
- Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders.
- Khan S, Godfrey V, Zaki MH Int Rev Cell Mol Biol 2019 344 215-253
- LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages.
- Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH, Mandal SS Sci Rep 2018 Oct 8 1 15670
- Inflammatory Proteomic Network Analysis of Statin-treated and Lipopolysaccharide-activated Macrophages
- Kamal AHM, Chakrabarty JK, Udden SMN, Zaki MH, Chowdhury SM Scientific Reports 2018 164 8
- The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defense
- Rajalakshmi A. Ramachandran, Christopher Lupfer and Hasan Zaki Advances in Microbial Physiology 2018 In press
- Changes in the Dielectric Spectra of Murine Colon During Neoplastic Progression
- Ahmet C. Sabuncu, Jeanne Shen, Md. Hasan Zaki, Ali Beskok Biomed. Phys. Eng. Express 2018
- The Ex Vivo Colon Organ Culture and Its Use in Antimicrobial Host Defense Studies
- Udden, S. M., Waliullah, S., Harris, M., Zaki, H. J. Vis. Exp. 2017 120
- The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.
- Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD. Immunity 2015
- Drak2 is not required for tumor surveillance and suppression.
- Edwards BA, Harris TL, Floersh H, Lukens JR, Zaki MH, Vogel P, Kanneganti TD, Bui JD, McGargill MA. 2015
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)