Hasan Zaki, Ph.D., Assistant Professor of Pathology, studies gastrointestinal inflammation and cancer. His research interests include host-pathogen interaction, the role of pathogen sensors in intestinal inflammation and cancer, pathogenic mechanisms of inflammatory bowel disease and colorectal cancer, and identifying immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.
Dr. Zaki earned his undergraduate and master's degrees in microbiology at the University of Dhaka, Bangladesh. He then joined the International Center for Diarrheal Disease Research, Bangladesh, where he studied immune responses against enteric pathogens. He did his doctoral research in the Department of Microbiology at Kumamoto University School of Medicine, Kumamoto, Japan, where he investigated the molecular mechanisms of host defense function of nitric oxide during gastrointestinal infection caused by Salmonella Typhimurium.
Dr. Zaki did postdoctoral research at Kumamoto University and later at St. Jude Children's Research Hospital in Memphis, Tenn. His postdoctoral studies demonstrated how NOD-like receptor (NLR) family members, particularly NLRP3 and NLRP12, suppress intestinal inflammation and cancer, and maintain intestinal homeostasis. His recent study shows that cytosolic DNA sensor AIM2 is a critical regulator of intestinal microbiota and inflammation.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Colorectal Cancer
- Gastrointestinal Inflammatory Disorders
- Gut Microbiome
- Host Pathogen Interaction
- NOD-Like Receptors
- NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.
- Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
- Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.
- Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
- Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60
- The Nlrp3 inflammasome: contributions to intestinal homeostasis.
- Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
- Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91
- Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
- Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T Nat. Chem. Biol. 2007 Nov 3 11 727-35
- Inflammatory Proteomic Network Analysis of Statin-treated and Lipopolysaccharide-activated Macrophages
- Kamal AHM, Chakrabarty JK, Udden SMN, Zaki MH, Chowdhury SM Scientific Reports 2018 164 8
- The Inflammasome: Regulation of Nitric Oxide and Antimicrobial Host Defense
- Rajalakshmi A. Ramachandran, Christopher Lupfer and Hasan Zaki Advances in Microbial Physiology 2018 In press
- Changes in the Dielectric Spectra of Murine Colon During Neoplastic Progression
- Ahmet C. Sabuncu, Jeanne Shen, Md. Hasan Zaki, Ali Beskok Biomed. Phys. Eng. Express 2018
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)