Hasan Zaki, PhD is an Assistant Professor in the Department of Pathology. Dr. Zaki studies molecular mechanism of inflammatory disorders including inflammatory bowel disease, colorectal cancer, hepatocellular carcinoma, obesity, fatty liver disease, and metabolic syndrome. Dr. Zaki earned his doctoral degree from Kumamoto University, Japan where he investigated the role of nitric oxide, an innate immune mediator, in host defense against bacterial infection and discovered that nitro-cyclic GMP, a nitrated nucleotide derivative, acts as a potential signal transduction molecule. For postdoctoral training, he moved to St. Jude Children’s Research Hospital, Memphis, TN where he studied the role of NOD-like receptors (NLR), a group of cytosolic pathogen recognition receptor, in intestinal inflammation and cancer.
Research in Dr. Zaki’s lab aims to dissect cell signaling pathways regulated by NLRs and other pathogen sensors. He previously explored that NLRP3 and AIM2 are critical inflammasome activating sensors involved in maintaining intestinal homeostasis and healthy gut microbiota composition. He also demonstrated that some NLRs such as NLRP12 and NOD2 protect host against colitis, colorectal cancer, and hepatocellular carcinoma via suppression of inflammatory signaling pathways. Ongoing studies in his laboratory is focused on understanding how innate pathogen sensors regulate gut microbiota composition, host metabolism, inflammation, and cancer. He is also interested in understanding the impact of diet in gastrointestinal, hepatobiliary, and metabolic disorders and how innate immune response intervenes diet-mediated modulation of gut microbiota and inflammatory disorders.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Cell Signaling
- Diet and Metabolic Disorders
- Gastrointestinal Inflammation and Cancer
- Gut Microbiome
- Host Pathogen Interaction
- NOD-Like Receptors
- Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice
- Shahanshah Khan, Sumyya Waliullah, Victoria Godfrey, Md Abdul Wadud Khan, Rajalaksmy A Ramachandran, Brandi L. Cantarel, Cassie Behrendt, Lan Peng, Lora V. Hooper, and Hasan Zaki Science Translational Medicine 2020
- NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
- SM Nashir Udden, Youn-tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Md Hasan Zaki eLIFE 2019
- NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.
- Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
- Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.
- Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
- Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60
- The Nlrp3 inflammasome: contributions to intestinal homeostasis.
- Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
- Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91
- Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
- Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T Nat. Chem. Biol. 2007 Nov 3 11 727-35
- Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma.
- Khan S, Zaki H, Int J Mol Sci 2020 Jan 21 2
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)