Hasan Zaki, Ph.D., Assistant Professor of Pathology, studies gastrointestinal inflammation and cancer. His research interests include host-pathogen interaction, the role of pathogen sensors in intestinal inflammation and cancer, pathogenic mechanisms of inflammatory bowel disease and colorectal cancer, and identifying immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.

Dr. Zaki earned his undergraduate and master's degrees in microbiology at the University of Dhaka, Bangladesh. He then joined the International Center for Diarrheal Disease Research, Bangladesh, where he studied immune responses against enteric pathogens. He did his doctoral research in the Department of Microbiology at Kumamoto University School of Medicine, Kumamoto, Japan, where he investigated the molecular mechanisms of host defense function of nitric oxide during gastrointestinal infection caused by Salmonella Typhimurium.

Dr. Zaki did postdoctoral research at Kumamoto University and later at St. Jude Children's Research Hospital in Memphis, Tenn. His postdoctoral studies demonstrated how NOD-like receptor (NLR) family members, particularly NLRP3 and NLRP12, suppress intestinal inflammation and cancer, and maintain intestinal homeostasis. His recent study shows that cytosolic DNA sensor AIM2 is a critical regulator of intestinal microbiota and inflammation. 


Graduate School
Kumamoto University - Japan (2007), Microbiology

Research Interest

  • Colorectal Cancer
  • Gastrointestinal Inflammatory Disorders
  • Gut Microbiome
  • Host Pathogen Interaction
  • NOD-Like Receptors


Featured Publications LegendFeatured Publications

Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders.
Khan S, Godfrey V, Zaki MH Int Rev Cell Mol Biol 2019 344 215-253
LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages.
Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH, Mandal SS Sci Rep 2018 Oct 8 1 15670

Honors & Awards

  • Career Development Award, Crohn's and Colitis Foundation of America (2012)
  • MEXT Scholarship (2002)
  • Trainee Award, American Association for Immunologists (2011)
  • Travel Award, Keystone Meeting (2012)

Professional Associations/Affiliations

  • American Association for Advancement of Schience (2012)
  • American Association of Immunologists (2012)
  • Chron's and Colitis Foundation of America (2012)