Hasan Zaki, Ph.D., Assistant Professor of Pathology, studies gastrointestinal inflammation and cancer. His research interests include host-pathogen interaction, the role of pathogen sensors in intestinal inflammation and cancer, pathogenic mechanisms of inflammatory bowel disease and colorectal cancer, and identifying immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.
Dr. Zaki earned his undergraduate and master's degrees in microbiology at the University of Dhaka, Bangladesh. He then joined the International Center for Diarrheal Disease Research, Bangladesh, where he studied immune responses against enteric pathogens. He did his doctoral research in the Department of Microbiology at Kumamoto University School of Medicine, Kumamoto, Japan, where he investigated the molecular mechanisms of host defense function of nitric oxide during gastrointestinal infection caused by Salmonella Typhimurium.
Dr. Zaki did postdoctoral research at Kumamoto University and later at St. Jude Children's Research Hospital in Memphis, Tenn. His postdoctoral studies demonstrated how NOD-like receptor (NLR) family members, particularly NLRP3 and NLRP12, suppress intestinal inflammation and cancer, and maintain intestinal homeostasis. His recent study shows that cytosolic DNA sensor AIM2 is a critical regulator of intestinal microbiota and inflammation.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Colorectal Cancer
- Gastrointestinal Inflammatory Disorders
- Gut Microbiome
- Host Pathogen Interaction
- NOD-Like Receptors
- NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
- SM Nashir Udden, Youn-tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Md Hasan Zaki eLIFE 2019
- NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.
- Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
- Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.
- Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
- Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60
- The Nlrp3 inflammasome: contributions to intestinal homeostasis.
- Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
- Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91
- Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
- Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, Akaike T Nat. Chem. Biol. 2007 Nov 3 11 727-35
- Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders.
- Khan S, Godfrey V, Zaki MH Int Rev Cell Mol Biol 2019 344 215-253
- LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages.
- Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH, Mandal SS Sci Rep 2018 Oct 8 1 15670
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)