Hasan Zaki, PhD is an Assistant Professor in the Department of Pathology. Dr. Zaki studies molecular mechanism of inflammatory disorders including inflammatory bowel disease, colorectal cancer, hepatocellular carcinoma, obesity, fatty liver disease, and metabolic syndrome.
Dr. Zaki earned his doctoral degree from Kumamoto University, Japan where he investigated the role of nitric oxide in host defense against bacterial infection and discovered that nitro-cyclic GMP, a nitrated nucleotide derivative, acts as a potential signal transduction molecule. For postdoctoral training, he moved to Dr. Thirumala-devi Kanneganti's laboratory at St. Jude Children’s Research Hospital, Memphis, TN. His postdoctoral studies were focused on understanding the role of NOD-like receptors (NLR), a group of cytosolic pathogen recognition receptor, in intestinal inflammatory disorders.
Research in Dr. Zaki’s lab aims to dissect signaling pathways regulated by NLRs and other pathogen sensors. He showed that NLRP3 and AIM2 are critical inflammasome activating sensors involved in maintaining intestinal homeostasis and healthy gut microbiota composition. He also demonstrated that several NLRs including NOD2 and NLRP12 play central roles in suppressing intestinal inflamamtion and colorectal cancer via downregualtion of inflammatory signaling pathways, such as NF-kB and MAPK. His laboratory also made seminal discovery that higher intake of dietary sugars predisposes and enhances pathogenesis of inflammatory bowel disease via modulaiton of gut microbiota composiiton. Ongoing studies in his laboratory is focused on understanding the complex interplay between innate iimmunity, diet, and gut microbiota in regulating intestinal homeostasis and inflammatory disorders including cancer.
- Graduate School
- Kumamoto University - Japan (2007), Microbiology
- Cell Signaling
- Diet and Metabolic Disorders
- Gastrointestinal Inflammation and Cancer
- Gut Microbiome
- Host Pathogen Interaction
- NOD-Like Receptors
- SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-kB pathway
- Shahanshah Khan, Mahnoush S. Shafiei, Christopher Longoria, John Schoggins, Rashmin C. Savani, Hasan Zaki BioRxiv 2021
- The AIM2 and NLRP3 inflammasomes coordinately mediate the effect of radiation by facilitating IL-1 signaling in dendritic cells
- Chuanhui Han, Victoria Godfrey, Zhida Liu, Yanfei Han, Longchao Liu, Hua Peng, Ralph W, Weichselbaum, Hasan Zaki*, Yang-Xin Fu*. * co-correspondence Science Immunology 2021 6 59
- Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice
- Shahanshah Khan, Sumyya Waliullah, Victoria Godfrey, Md Abdul Wadud Khan, Rajalaksmy A Ramachandran, Brandi L. Cantarel, Cassie Behrendt, Lan Peng, Lora V. Hooper, and Hasan Zaki Science Translational Medicine 2020
- NLRP12 suppresses hepatocellular carcinoma via downregulation of cJun N-terminal kinase activation in the hepatocyte
- SM Nashir Udden, Youn-tae Kwak, Victoria Godfrey, Md Abdul Wadud Khan, Shahanshah Khan, Nicolas Loof, Lan Peng, Hao Zhu, Md Hasan Zaki eLIFE 2019
- NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR Pathways.
- Udden SMN, Peng L, Gan JL, Shelton JM, Malter JS, Hooper LV, Zaki MH Cell Rep 2017 Jun 19 13 2756-2770
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
- Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36
- Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection.
- Zaki MH, Man SM, Vogel P, Lamkanfi M, Kanneganti TD Proc. Natl. Acad. Sci. U.S.A. 2014 Jan 111 1 385-90
- The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
- Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J, Green DR, Lamkanfi M, Kanneganti TD Cancer Cell 2011 Nov 20 5 649-60
- The Nlrp3 inflammasome: contributions to intestinal homeostasis.
- Zaki MH, Lamkanfi M, Kanneganti TD Trends Immunol. 2011 Apr 32 4 171-9
- The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
- Zaki MH, Boyd KL, Vogel P, Kastan MB, Lamkanfi M, Kanneganti TD Immunity 2010 Mar 32 3 379-91
Honors & Awards
- Career Development Award, Crohn's and Colitis Foundation of America (2012)
- MEXT Scholarship (2002)
- Trainee Award, American Association for Immunologists (2011)
- Travel Award, Keystone Meeting (2012)
- American Association for Advancement of Schience (2012)
- American Association of Immunologists (2012)
- Chron's and Colitis Foundation of America (2012)