My research is focused on growth factor and nutrient signaling pathways that regulate pancreatic islet cell function and developing novel in vitro models to monitor secretion and expression of insulin and glucagon.


Purdue University (2007), Biochemistry
Graduate School
Indiana Uni - Purdue Uni I (2012), Biochemistry


Featured Publications LegendFeatured Publications

Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.
Guerra ML, Kalwat MA, McGlynn K, Cobb MH FEBS Open Bio 2017 Feb 7 2 174-186
Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in ß-Cells.
Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH ACS Chem. Biol. 2016 Apr 11 4 1128-36
A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic ß cells.
Kalwat MA, Yoder SM, Wang Z, Thurmond DC Biochem. Pharmacol. 2013 Mar 85 6 808-16
Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.
Kalwat MA, Wiseman DA, Luo W, Wang Z, Thurmond DC Mol. Endocrinol. 2012 Jan 26 1 128-41

Professional Associations/Affiliations

  • Department of Pharmacology (2018)