Biography

I am a biochemist studying the biological interactions of sugars.  Raised and educated in New York City, I received a B.S. in Biochemistry from nearby Stony Brook University in 1977.  I then began a fruitful southerly migration, entering graduate school at Duke, where I worked with Robert Hill and obtained a Ph.D. in Biochemistry 1982.  

I continued southward to UT Southwestern in Dallas for a postdoctoral fellowship with Michael Brown and Joseph Goldstein in 1983. This experience was highly rewarding for me, and I decided to stay at UT Southwestern, where I am currently a Professor in the Department of Pharmacology.

My training at Duke and UT Southwestern led me to an interest in glycobiology. This is an emerging field that studies essential roles of sugars, in all domains of life, but roles that are not directly related to nutrition or energy metabolism.

In glycobiology, we study well-known sugars like glucose, and lesser known structural cousins such as mannose, as parts of polymers (glycans). These glycans can be free, or covalently attached to proteins and lipids, and are recognized by highly specific glycan-binding proteins called lectins.

The glycans we study are amazing! They are critically involved in protein sorting and folding, cell-cell interaction, signaling, and pathogen binding, just to name a few examples.

There are approximately 100 human genetic diseases caused by mistakes in synthesizing these glycans!  Currently, we are studying free glycans as signaling molecules, anti-viral agents, and inducers of autoimmunity.

Education

Undergraduate
SUNY at Stony Brook (1977)
Graduate School
Duke University (1982)

Research Interest

  • Glycoconjugates of the Mammalian Endoplasmic Reticulum
  • N-linked Glycosylation and the Dolichol Pathway
  • Rare Metabolic Diseases Involving Sugar Abnormalities

Publications

Featured Publications LegendFeatured Publications

Analysis of glycosylation in CDG-Ia fibroblasts by fluorophore-assisted carbohydrate electrophoresis: implications for extracellular glucose and intracellular mannose 6-phosphate.
Gao N, Shang J, Lehrman MA J. Biol. Chem. 2005 May 280 18 17901-9
Analysis Of Glycosylation In CDG-Ia Fibroblasts By Fluorophore-Assisted Carbohydrate Electrophoresis: Implications For Extracellular Glucose And Intracellular Mannose-6-Phosphate
Gao, N., Shang, J., and Lehrman, M. A. The Journal Of Biological Chemistry 2005 280 17901-17909
Activation of glycogen phosphorylase with 5-aminoimidazole-4-carboxamide riboside (AICAR)
Shang, J. and Lehrman, M.A. Journal of Biological Chemistry March 2004 Vol. 279 12076-12080
Analyses of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues by fluorophore-assisted carbohydrate electrophoresis.
Gao N, Lehrman MA Glycobiology 2002 May 12 5 353-60
Regulation Of The Dolichol Pathway In Human Fibroblasts By The Endoplasmic Reticulum Unfolded Protein Response.
Doerrler, W. T. and Lehrman, M. A. Proc. Natl. Acad Sci. USA 1999 96 13050-13055 (Track II)
Expression Cloning Of A Novel Suppressor Of The Lec15 and Lec35 Glycosylation Mutations Of Chinese Hamster Ovary Cells.
Ware, F.E. and Lehrman, M. A. Journal of Biological Chemistry 1996 271 13935-13938
The Molecular Chaperone Calnexin Binds Glc1Man9GlcNAc2 Oligosaccharide As An Initial Step In Recognizing Unfolded Glycoproteins.
Ware, F.E., Vassilakos, A., Jackson, M., Lehrman, M.A. and Williams, D.B. Journal of Biological Chemistry 1995 270 4697-4704

Honors & Awards

  • Jane Coffin Childs Memorial Fund
    Research Fellowship, 1984 - 1985 (0)
  • National Institutes of Health
    Postdoctoral Fellowship, 1983 (0)
  • Regents College Scholarship
    1973 - 1977 (0)
  • Searle Scholars Program
    1987 - 1990 (0)

Professional Associations/Affiliations

  • Associate Editor, Glycobiology (2004-2011)
  • Editorial Board, Journal of Biological Chemistry (1994-1998, 2012-2016)
  • President, Society For Glycobiology (2008)
  • Reviewer, Pathobiochemistry Study Section, NIH (1996-2000)