Colleen Noviello grew up in New York state and attended New York University for her bachelor's degree. She then completed her doctorate at the University of California, San Diego in the laboratory of Dr. John Guatelli, MD, where she explored host-mechanisms of HIV infection. This work led to post-doctoral research examining the pathogenic immune evasion response. Currently she works with Dr. Ryan Hibbs utilizing cryo-electron microscopy to study atomic level interactions of neuronal cell surface receptors. Recently Dr. Noviello developed a new branch of the Hibbs laboratory examining how an improper immune response targeting one’s own neuronal receptors can cause disease. This neuroimmunology project spans clinical collaborations, ion channel pharmacology and biophysics, and structural biology.  



For a complete listing of peer-reviewed publications, please go to this link: 


New York University (1999), Biology
Graduate School
Uni of California-San Diego (2007), Biomedical Sciences


Featured Publications LegendFeatured Publications

Structure and gating mechanism of the a7 nicotinic acetylcholine receptor.
Noviello CM, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, Sine SM, Hibbs RE, Cell 2021 04 184 8 2121-2134.e13
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh RM, Lindahl E, Hibbs RE, Nature 2020 09 585 7824 303-308
Progress in nicotinic receptor structural biology.
Gharpure A, Noviello CM, Hibbs RE, Neuropharmacology 2020 07 171 108086
Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.
Rahman MM, Teng J, Worrell BT, Noviello CM, Lee M, Karlin A, Stowell MHB, Hibbs RE, Neuron 2020 06 106 6 952-962.e5
Agonist Selectivity and Ion Permeation in the a3?4 Ganglionic Nicotinic Receptor.
Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE, Neuron 2019 11 104 3 501-511.e6
Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant ? Subunits Acquire Sensitivity to a7-Selective Positive Allosteric Modulators.
Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL, J Pharmacol Exp Ther 2019 08 370 2 252-268
Structure of a human synaptic GABAA receptor.
Zhu S, Noviello CM, Teng J, Walsh RM, Kim JJ, Hibbs RE, Nature 2018 07 559 7712 67-72
X-ray structure of the human a4?2 nicotinic receptor.
Morales-Perez CL, Noviello CM, Hibbs RE, Nature 2016 Oct 538 7625 411-415
Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins.
Morales-Perez CL, Noviello CM, Hibbs RE, Structure 2016 05 24 5 797-805
Second-site compensatory mutations of HIV-1 capsid mutations.
Noviello CM, López CS, Kukull B, McNett H, Still A, Eccles J, Sloan R, Barklis E, J Virol 2011 May 85 10 4730-8