Zengfu Shang, Ph.D.

Undergraduate

Central China Normal Univ (2004), Biotechnology

Graduate School

Beijing Inst of Radiation Med (2009), Biochemistry

Featured Publications

Tumor suppressor protein DAB2IP participates in chromosomal stability maintenance through activating spindle assembly checkpoint and stabilizing kinetochore-microtubule attachments.

Yu L, Shang ZF, Abdisalaam S, Lee KJ, Gupta A, Hsieh JT, Asaithamby A, Chen BP, Saha D Nucleic Acids Res. 2016 Oct 44 18 8842-8854

Suppression of PC-1/PrLZ sensitizes prostate cancer cells to ionizing radiation by attenuating DNA damage repair and inducing autophagic cell death.

Shang ZF, Wei Q, Yu L, Huang F, Xiao BB, Wang H, Song M, Wang L, Zhou J, Wang J, Li S Oncotarget 2016 Sep 7 38 62340-62351

Hydroxylated-graphene quantum dots induce cells senescence in both p53-dependent and -independent manner

Tian X, Xiao BB, Wu A, Yu L, Zhou J, Wang Y, Wang N, Guan H, Shang ZF Toxicol. Res. 2016 Sep 5 1639-1648

DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability.

Shang Z, Yu L, Lin YF, Matsunaga S, Shen CY, Chen BP Oncogenesis 2014 Feb 3 e85

Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.

Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD, Wang Y, Zhou PK Cancer Res. 2010 May 70 9 3657-66

Downregulation of Enhancer of Zeste Homolog 2 (EZH2) is essential for the Induction of Autophagy and Apoptosis in Colorectal Cancer Cells.

Yao Y, Hu H, Yang Y, Zhou G, Shang Z, Yang X, Sun K, Zhan S, Yu Z, Li P, Pan G, Sun L, Zhu X, He S Genes (Basel) 2016 Oct 7 10

Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection.

Zhang S, Matsunaga S, Lin YF, Sishc B, Shang Z, Sui J, Shih HY, Zhao Y, Foreman O, Story MD, Chen DJ, Chen BP Oncogene 2016 Jul 35 30 3909-18

Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells.

Song M, Wang Y, Shang ZF, Liu XD, Xie DF, Wang Q, Guan H, Zhou PK Sci Rep 2016 Jul 6 30165

DNA polymerase iota (Pol ?) promotes invasion and metastasis of esophageal squamous cell carcinoma.

Zou S, Shang ZF, Liu B, Zhang S, Wu J, Huang M, Ding WQ, Zhou J Oncotarget 2016 May 7 22 32274-85

REV3L, the catalytic subunit of DNA polymerase ?, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma.

Zhu X, Zou S, Zhou J, Zhu H, Zhang S, Shang Z, Ding WQ, Wu J, Chen Y Oncol. Rep. 2016 Mar 35 3 1664-70