Dr. Marrero is received his gastroenterology training at the University of Illinois at Chicago, where he found his interest in liver disease and liver transplantation. He has developed a clinical practice in liver transplantation over 15 years. His research in this topic covers early diagnosis, staging and novel therapies for primary liver cancer (Hepatocellular Carcinoma). His grant funding and peer-review publication record shows the diversity of his research within HCC. His major contributions have been on a strategy for validating biomarkers for early detection; his group developed the imaging characteristics for diagnosing HCC; his study on HCC staging systems validated the Barcelona staging system; and has published several papers on treatment, specifically on liver transplantation for early stage HCC and on advanced HCC. He is considered an expert in this topic and is part of several national committees. He is a founding member of the International Liver Cancer Association, a member of The American Association for the Study of Liver Disease, American College of Gastroenterology and the American Gastroenterological Association, and a member of the National Comprehensive Cancer Network’s Hepatobiliary Committee. Dr. Marrero has lectured globally and has written and reviewed numerous research articles and book chapters for publications such as the New England Journal of Medicine, the Journal of the American Medical Association, the Journal of the National Cancer Institute and the Journal of Clinical Oncology. His outside interests are golf, tennis, and shuttling his 2 sons for various activities.


Medical School
Ponce School of Medicine (1993)
Drexel University College of Medicine (1996), Internal Medicine
University of Illinois College of Medicine at Chicago (1999), Gastroenterology
Graduate School
University of Michigan Medical School (2003)
Other Post Graduate Training
University of Michigan Medical School (2003)

Research Interest

  • Hepatocellular carcinoma
  • Liver transplantation


Featured Publications LegendFeatured Publications

Effectiveness of hepatocellular carcinoma surveillance in patients with cirrhosis.
Singal AG, Conjeevaram HS, Volk ML, Fu S, Fontana RJ, Askari F, Su GL, Lok AS, Marrero JA Cancer Epidemiol. Biomarkers Prev. 2012 May 21 5 793-9
Identification of osteopontin as a novel marker for early hepatocellular carcinoma.
Shang S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L Hepatology 2012 Feb 55 2 483-90
Value of delayed hypointensity and delayed enhancing rim in magnetic resonance imaging diagnosis of small hepatocellular carcinoma in the cirrhotic liver.
Khan AS, Hussain HK, Johnson TD, Weadock WJ, Pelletier SJ, Marrero JA J Magn Reson Imaging 2010 Aug 32 2 360-6
An intention-to-treat analysis of liver transplantation for hepatocellular carcinoma using organ procurement transplant network data.
Pelletier SJ, Fu S, Thyagarajan V, Romero-Marrero C, Batheja MJ, Punch JD, Magee JC, Lok AS, Fontana RJ, Marrero JA Liver Transpl. 2009 Aug 15 8
Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma.
Marrero JA, Feng Z, Wang Y, Nguyen MH, Befeler AS, Roberts LR, Reddy KR, Harnois D, Llovet JM, Normolle D, Dalhgren J, Chia D, Lok AS, Wagner PD, Srivastava S, Schwartz M Gastroenterology 2009 Jul 137 1 110-8


Featured Books Legend Featured Books

Honors & Awards

  • Best Doctors in America
  • Best Doctors in America
  • Chair, Hepatobiliary Neoplasia Special Interest Group
    AASLD (2011)
  • AW Research Excellence in Liver Cancer
  • Best Doctors in America
  • Best Doctors in America
  • Best Doctors in America
  • Best Doctors in America
  • Best Doctors in America
  • Best Doctors in America
  • Research Excellence in Gastroenterology and Liver Award

Professional Associations/Affiliations

  • Internal Liver Cancer Association (2006)
  • American Association for the Study of Liver Disease (1999)
  • American Gastroenterological Association (1999)