Yunsun Nam is an Associate Professor in the Department of Biochemistry and the Department of Biophysics. She is also a member of the Harold C. Simmons Comprehensive Cancer Center.
Dr. Nam obtained her BA in Biochemical Sciences from Harvard College working on her honors thesis in Dr. Daniel Hartl's laboratory. She obtained her PhD in Biological Chemistry and Molecular Pharmacology working in Dr. Stephen Blacklow's group at Harvard Medical School. She completed postdoctoral training at Harvard Medical School in Dr. Tom A. Rapoport’s laboratory in the Department of Cell Biology and then in Dr. Piotr Sliz's laboratory in the Department of Biological Chemistry and Molecular Pharmacology.
Dr. Nam studies mechanisms of non-coding RNAs and their role in gene regulation important for development and cancer. Areas of focus include the molecular mechanisms and regulation of microRNA biogenesis and chemical modification of RNAs. Her laboratory uses various biochemical and biophysical approaches including X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, molecular biology, nucleic acid/protein biochemistry, high throughput screening, next-generation sequencing, and eukaryotic cell-based studies. Her long-term goal is not only to elucidate how ncRNAs work to ensure proper gene regulation but also to identify new avenues for developing therapeutics.
- Harvard Uni-Harvard College (1999), Biocchemical Sciences
- Graduate School
- Harvard University (2006)
- Gene regulation
- non-coding RNAs
- Structure and Function of Macromolecular complexes
- Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
- Partin AC, Zhang K, Jeong BC, Herrell E, Li S, Chiu W, Nam Y, Mol. Cell 2020 Mar
- RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
- Ngo TD, Partin AC, Nam Y, Cell Rep 2019 Dec 29 12 4024-4035.e5
- Manipulation by Methylation: Garnishing mRNAs with m6Am.
- Doxtader KA, Nam Y, Mol. Cell 2019 08 75 3 417-418
- Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor.
- Doxtader KA, Wang P, Scarborough AM, Seo D, Conrad NK, Nam Y Mol. Cell 2018 Sep 71 6 1001-1011.e4
- Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.
- Wang L, Rowe RG, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P Cell Rep 2018 Jun 23 10 3091-3101
- Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
- Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, Nam Y Nat Commun 2017 Nov 8 1 1737
- LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.
- Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P Cell Rep 2017 Mar 18 11 2664-2675
- HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.
- Liu H, Liang C, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang Z, Yoo KS, Yadav GP, Kinch LN, Grishin NV, Nam Y, Corey DR, Kittler R, Liu Q Mol. Cell 2016 Jul
- Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
- Wang P, Doxtader KA, Nam Y Mol. Cell 2016 Jun
- Publisher Correction: Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
- Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, Nam Y Nat Commun 2018 Sep 9 1 3852
Honors & Awards
- MAVEN scholar
- Kavli Fellow, National Academy of Sciences
- Pew Scholar in the Biomedical Sciences
- Cancer Prevention Research Institute of Texas
First Time Faculty Recruitment Award (2013)
- Packard Fellowship for Science and Engineering
The David and Lucile Packard Foundation (2013)
- Southwestern Medical Foundation Scholar in Biomedical Research
Endowed Scholars Program, The University of Texas Southwestern Medical Center (2013)
- Charles A. King Trust Postdoctoral Research Fellowship
- Damon Runyon Postdoctoral Fellowship
- The Jane Coffin Childs Postdoctoral Fellowship