Yunsun Nam is an Assistant Professor in the Department of Obstetrics and Gynecology and the Department of Biophysics. She is a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences.
Dr. Nam obtained a BA in Biochemical Sciences from Harvard College. Under the direction of Dr. Stephen C. Blacklow, she obtained her PhD in Biological Chemistry and Molecular Pharmacology. Following this, she completed postdoctoral fellowships at Harvard Medical School in Dr. Tom A. Rapoport’s laboratory in the Department of Cell Biology and then in Dr. Piotr Sliz's laboratory in the Department of Biological Chemistry and Molecular Pharmacology.
Dr. Nam studies mechanisms of non-coding RNAs and their role in gene regulation important for development and cancer. Areas of focus include the molecular mechanisms and regulation of microRNA processing and chemical modification of RNAs. Her laboratory uses various biochemical and biophysical approaches including X-ray crystallography, cryo-electron microscopy, NMR spectroscopy, molecular biology, nucleic acid/protein biochemistry, high throughput sequencing, and eukaryotic cell-based studies. Her long term goal is not only to elucidate how ncRNAs work to ensure proper gene regulation but also to identify new avenues for developing therapeutics.
- Graduate School
- Harvard University (2006)
- Gene regulation
- non-coding RNAs
- Structure and Function of Macromolecular complexes
- Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
- Partin AC, Zhang K, Jeong BC, Herrell E, Li S, Chiu W, Nam Y, Mol. Cell 2020 Mar
- RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
- Ngo TD, Partin AC, Nam Y, Cell Rep 2019 Dec 29 12 4024-4035.e5
- Manipulation by Methylation: Garnishing mRNAs with m6Am.
- Doxtader KA, Nam Y, Mol. Cell 2019 08 75 3 417-418
- Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor.
- Doxtader KA, Wang P, Scarborough AM, Seo D, Conrad NK, Nam Y Mol. Cell 2018 Sep 71 6 1001-1011.e4
- Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.
- Partin AC, Ngo TD, Herrell E, Jeong BC, Hon G, Nam Y Nat Commun 2017 Nov 8 1 1737
- HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.
- Liu H, Liang C, Kollipara RK, Matsui M, Ke X, Jeong BC, Wang Z, Yoo KS, Yadav GP, Kinch LN, Grishin NV, Nam Y, Corey DR, Kittler R, Liu Q Mol. Cell 2016 Jul
- Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
- Wang P, Doxtader KA, Nam Y Mol. Cell 2016 Jun
- Molecular basis for interaction of let-7 microRNAs with Lin28.
- Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P Cell 2011 Nov 147 5 1080-91
- Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
- Lazarus MB, Nam Y, Jiang J, Sliz P, Walker S Nature 2011 Jan 469 7331 564-7
- A role for the two-helix finger of the SecA ATPase in protein translocation.
- Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA Nature 2008 Oct 455 7215 984-7
Honors & Awards
- Pew Scholar in the Biomedical Sciences
- Cancer Prevention Research Institute of Texas
First Time Faculty Recruitment Award (2013)
- Packard Fellowship for Science and Engineering
The David and Lucile Packard Foundation (2013)
- Southwestern Medical Foundation Scholar in Biomedical Research
Endowed Scholars Program, The University of Texas Southwestern Medical Center (2013)
- Charles A. King Trust Postdoctoral Research Fellowship
Charles A. King Trust, N.A., Bank of America, Co‐Trustee. (2011)
- Damon Runyon Postdoctoral Fellowship
Damon Runyon Cancer Research Foundation (2007)
- The Jane Coffin Childs Postdoctoral Fellowship
The Jane Coffin Childs Memorial Fund for Medical Research (declined) (2007)