Imran Mir, M.D.
Associate Professor

Dr. Mir grew up in beautiful valley of Kashmir, which is located between the Great Himalayas and the Pir Panchal Range in the Indian subcontinent. He is a graduate of Government Medical College in Kashmir, India. He completed his internship and pediatric residency at the Oklahoma University Children's Hospital, Oklahoma City. He then obtained his training in Neonatal-Perinatal Medicine at UT Southwestern. After completing his Neonatal-Perinatal Medicine fellowship in 2015, he was recruited as faculty member in the division of Neonatal-Perinatal Medicine at UT Southwestern Medical School, where he is currently working as an Associate Professor of Pediatrics, and the Program Director for the Neonatal-Perinatal Fellowship Training Program.

Dr. Mir’s primary research focus is to understand the role of placental biology in neonatal morbidities. He has made several key observations including the placental contributions to neurodevelopmental outcomes after birth asphyxia and the role of placenta in clearance of fetal inflammatory responses. He has also studied the impact of multiple placental pathologic lesions with autism spectrum disorders in extremely preterm infants, thus shedding light on possible intrauterine risk factors with increased incidence of autism spectrum disorders in these vulnerable infants. He reported the placental clearance of neurobiomarker, GFAP, and showed for the first time that episodic hypoxia during normal labor can elicit the release of GFAP.

When he’s not working, he enjoys listening to semi-classical Indian music and spending time with his wife and two children. In addition to English, Dr. Mir speaks Kashmiri, Hindi and Urdu.

Medical School

Government Medical College, India (2003)

Residency

University of Oklahoma Health Sciences Center (2012), Pediatrics

Fellowship

UT Southwestern Medical Center/ Children's Medical Center (2015), Neonatal-perinatal Medicine

• Birth asphyxia and neontal encephalopathy
• Placental biology and neonatal morbidities, particularly neonatal brain injury

Featured Publications

Placental clearance not synthesis tempers exaggerated pro-inflammatory cytokine response in neonates exposed to chorioamnionitis.

Mir IN, Uddin N, Liao J, Brown LS, Leon R, Chalak LF, Savani RC, Rosenfeld CR, Pediatr Res 2022 Jun

Placental Vascular Malperfusion Lesions in Fetal Congenital Heart Disease.

Leon RL, Sharma K, Mir IN, Herrera CL, Brown SL, Spong CY, Chalak LF, Am J Obstet Gynecol 2022 May

Electrocardiogram for heart rate evaluation during preterm resuscitation at birth: a randomized trial.

Abbey NV, Mashruwala V, Weydig HM, Steven Brown L, Ramon EL, Ibrahim J, Mir IN, Wyckoff MH, Kapadia V, Pediatr Res 2021 Oct

TeleNICU: Extending the reach of level IV care and optimizing the triage of patient transfers.

Jagarapu J, Kapadia V, Mir I, Kakkilaya V, Carlton K, Fokken M, Brown S, Hall-Barrow J, Savani RC, J Telemed Telecare 2021 Sep 1357633X211038153

Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.

Leon RL, Mir IN, Herrera CL, Sharma K, Spong CY, Twickler DM, Chalak LF, Pediatr Res 2021 Apr

Placental origins of neonatal diseases: toward a precision medicine approach.

Mir IN, Leon R, Chalak LF, Pediatr Res 2020 Dec

Autism spectrum disorders in extremely preterm infants and placental pathology findings: a matched case-control study.

Mir IN, White SP, Steven Brown L, Heyne R, Rosenfeld CR, Chalak LF, Pediatr. Res. 2020 Sep

Placental Pathology, Cerebral Blood Flow, and Intraventricular Hemorrhage in Preterm Infants: Is There a Link?

Pazandak C, Mir IN, Brown LS, Chalak LF, Pediatr. Neurol. 2020 Jan

Vulnerable child syndrome in the neonatal intensive care unit: A review and a new preventative intervention with feasibility and parental satisfaction data

Margaret K. Hoge, Elizabeth Heyne, Theresa De Freitas Nicholson, Dailyn Acosta, Imran N. Mir, Larry S. Brown, Richard J. Shaw, Lina F. Chalak, Roy Heyne EarlHumDev 2020 Oct

Impact of multiple placental pathologies on neonatal death, bronchopulmonary dysplasia, and neurodevelopmental impairment in preterm infants.

Mir IN, Chalak LF, Brown LS, Johnson-Welch S, Heyne R, Rosenfeld CR, Kapadia VS, Pediatr. Res. 2019 Dec

 Featured Books

Regulation of Placental Circulation. In Fetal and Neonatal Physiology, 6th Edition. Polin RA, Abman SH, Rowitch D, Benitz WE, eds.

Imran N Mir, Charles R. Rosenfeld (2021). Philadelphia, Elsevier

• CCRAC Research Award
  Children's Clinical Research Advisory Committee (CCRAC), Children's Health Foundation (2020)
• Travel Grant Award by International Pediatric Research Foundation
  (2020)
• Early Career Investigator (ECI) Award
  (2019)
• Nominated for Rising Star Clinical Excellence Award at UT Southwestern Medical Center.
  (2018)
• Selected for 26th Annual NICHD Young Investigators Conference
  (2014)
• Travel Award
  AAP SCCPR Conference (2014)

• Newborn Brain Society (2020)
• Society for Pediatric Research (2020)
• Perinatal Research Society (2019)
• AAP, Section on Perinatal Pediatrics (2012)
• American Academy of Pediatrics (2009)