Jack O'Brien, M.D. Titles and Appointments Assistant Professor School Medical School Department Dermatology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Jack O’Brien, M.D., is an Assistant Professor in the Department of Dermatology at UT Southwestern Medical Center. He specializes in hidradenitis suppurativa, general dermatology, and skin cancer. Dr. O’Brien earned his medical degree at UT Southwestern Medical School, where he also completed a residency in dermatology, serving as Chief Resident. Certified by the American Board of Dermatology, he joined the UT Southwestern faculty in 2021. At UT Southwestern, Dr. O’Brien is the Medical Director of the Dermatology Clinic, the Director of the Hidradenitis Suppurativa Clinic, and the Associate Program Director of the Dermatology Residency. Dr. O’Brien is a Fellow of the American Academy of Dermatology. He serves as Secretary-Treasurer of the Dallas Dermatological Society and is a member of the Society for Investigative Dermatology. In addition, he is a faculty volunteer at the Agape Dermatology Clinic in Dallas. He has delivered presentations and published peer-reviewed academic articles related to his areas of expertise. He also contributed to the book Treatment of Skin Disease. Education Medical School UT Southwestern Medical School (2017) Internship UT Southwestern Medical Center (2018), Internal Medicine Residency UT Southwestern Medical Center (2021), Dermatology Publications Validation of CXCL9 as a biomarker of morphoea disease state and severity through longitudinal analysis Chen HW, Barber G, Foster J, Zigler CK, O'Brien JC, Jacobe HT British Journal of Dermatology 2025 Dec 193 1174-1181 The Use of Complementary and Alternative Medicine in Management of Hidradenitis Suppurativa Jain S, O’Brien JC, Harris-Tryon T Current Dermatology Reports 2024 Dec 13 315-323 When handed lemons, beware of squeezing them Zhu CS, Trickett J, O'Brien J, Cruz PD Contact Dermatitis 2024 Mar 90 327-328 Gene Expression Signatures in Inflammatory and Sclerotic Morphea Skin and Sera Distinguish Morphea from Systemic Sclerosis Chen HW, Zhu JL, Martyanov V, Tsoi LC, Johnson ME, Barber G, Popovich D, O'Brien JC, Coias J, Cyrus N, Malviya N, Florez-Pollack S, Kunzler E, Hosler GA, Gudjonsson JE, Khanna D, Whitfield M, Jacobe HT Journal of Investigative Dermatology 2023 Oct 143 1886-1895.e10 Elevated serum levels of C-X-C motif chemokine ligand 10 can distinguish systemic lupus erythematosus patients from cutaneous lupus erythematosus patients Zhu JL, O'Brien JC, Barber G, Saxena R, Chong BF Journal of the American Academy of Dermatology 2021 Oct 85 1051-1054 A Cross-sectional Comparison of Magnetic Resonance Imaging Findings and Clinical Assessment in Patients with Morphea Abbas LF, O'Brien JC, Goldman S, Pezeshk P, Chalian M, Chhabra A, Jacobe HT JAMA Dermatology 2020 May 156 590-592 Changes in Disease Activity and Damage over Time in Patients with Morphea O'Brien JC, Nymeyer H, Green A, Jacobe HT JAMA Dermatology 2020 May 156 513-520 Linear morphea: Clinical characteristics, disease course, and treatment of the Morphea in Adults and Children cohort Kunzler E, Florez-Pollack S, Teske N, O'Brien J, Prasad S, Jacobe H Journal of the American Academy of Dermatology 2019 Jun 80 1664-1670.e1 Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus O'Brien JC, Chong BF Journal of Investigative Dermatology Symposium Proceedings 2017 Oct 18 S69-S74 Transcriptional and Cytokine Profiles Identify CXCL9 as a Biomarker of Disease Activity in Morphea O'Brien JC, Rainwater YB, Malviya N, Cyrus N, Auer-Hackenberg L, Hynan LS, Hosler GA, Jacobe HT Journal of Investigative Dermatology 2017 Aug 137 1663-1670 Results 1-10 of 14 1 2 Next Last Professional Associations/Affiliations American Academy of Dermatology Dallas Dermatological Society Society for Investigative Dermatology
