Hao Zhu, M.D. Professor Endowed Title The Nancy B. and Jake L. Hamon Distinguished Chair in Therapeutic Oncology Research School Medical School Department Children's Medical Center Research Institute at UT Southwestern | Internal Medicine | Pediatrics Graduate Programs Cancer Biology, Genetics, Development and Disease You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Hao Zhu earned his bachelor’s degree in biology from Duke University, followed by an M.D. from Harvard Medical School and MIT. He underwent clinical training in internal medicine at the University of California, San Francisco, and medical oncology at the Dana-Farber Cancer Institute. Dr. Zhu performed postdoctoral research in George Daley’s laboratory at Boston Children’s Hospital from 2008 to 2012. He joined the faculty of Children’s Medical Center Research Institute at UT Southwestern in 2012. Dr. Zhu is the Director of CRI's Tissue Regeneration Program and a co-leader of the Development and Cancer Research Program in the Simmons Comprehensive Cancer Center. As a medical oncologist, he treats hepatocellular carcinoma patients in the Multidisciplinary Liver Cancer Clinic at Parkland Memorial Hospital. Dr. Zhu is the recipient of a Burroughs Wellcome Career Award for Medical Scientists (2012), a CPRIT Scholar Award (2012), a Stand Up To Cancer Innovative Research Grant (2016), and the Mark Foundation Emerging Leader Award (2021). Dr. Zhu holds the Nancy B. and Jake L. Hamon Distinguished Chair in Therapeutic Oncology Research. Using the liver as a model system, the Zhu laboratory is trying to elucidate how injury, regeneration, and wound healing influence organ function and cancer formation. They believe that understanding somatic mosaicism will be a key genetic strategy to deconvolute the complexity of wound healing and are using human genomic approaches, in vivo genetic screening, and lineage tracing to understand the functional implications of somatic mosaicism in chronic liver disease and liver cancer. Education Medical School Harvard Medical School (2005) Residency University of California, San Francisco (2007), Internal Medicine Fellowship Dana-Farber Cancer Institute (2011), Hematology Oncology Research Interest Chronic liver disease In vivo genetic screening Liver cancer Liver regeneration Mechanisms of organ regeneration Publications Featured Publications IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration. Lin YH, Wei Y, Zeng Q, Wang Y, Pagani CA, Li L, Zhu M, Wang Z, Hsieh MH, Corbitt N, Zhang Y, Sharma T, Wang T, Zhu H, Cell Stem Cell 2023 May 30 5 665-676.e4 Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease. Wang Z, Zhu S, Jia Y, Wang Y, Kubota N, Fujiwara N, Gordillo R, Lewis C, Zhu M, Sharma T, Li L, Zeng Q, Lin YH, Hsieh MH, Gopal P, Wang T, Hoare M, Campbell P, Hoshida Y, Zhu H, Cell 2023 Apr 186 9 1968-1984.e20 In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration. Jia Y, Li L, Lin YH, Gopal P, Shen S, Zhou K, Yu X, Sharma T, Zhang Y, Siegwart DJ, Ready JM, Zhu H, Cell Stem Cell 2022 Jan Liver homeostasis is maintained by midlobular zone 2 hepatocytes. Wei Y, Wang YG, Jia Y, Li L, Yoon J, Zhang S, Wang Z, Zhang Y, Zhu M, Sharma T, Lin YH, Hsieh MH, Albrecht JH, Le PT, Rosen CJ, Wang T, Zhu H, Science 2021 02 371 6532 Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Zhu M, Lu T, Jia Y, Luo X, Gopal P, Li L, Odewole M, Renteria V, Singal AG, Jang Y, Ge K, Wang SC, Sorouri M, Parekh JR, MacConmara MP, Yopp AC, Wang T, Zhu H, Cell 2019 Apr The Polyploid State Plays a Tumor-Suppressive Role in the Liver. Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal P, Tarlow BD, Siegwart DJ, Zhu H Dev. Cell 2018 Feb Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice without Affecting Regeneration. Zhang S, Nguyen LH, Zhou K, Tu HC, Sehgal A, Nassour I, Li L, Gopal P, Goodman J, Singal AG, Yopp A, Zhang Y, Siegwart DJ, Zhu H Gastroenterology 2017 Dec Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer. Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H Cancer Cell 2017 Nov 32 5 574-589.e6 Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration. Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H Cell Stem Cell 2016 Mar Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ, Zhu H Cancer Cell 2014 Aug 26 2 248-61 Results 1-10 of 35 1 2 3 4 Next Last Honors & Awards Mark Foundation Emerging Leader Award (2021-2024) Member of the American Society of Clinical Investigation (2018) SU2C Innovative Research Grant (2016-2019) Burroughs Wellcome Fund Career Award for Medical Scientists (2012) CPRIT Scholar in Cancer Research (2012)
