John Schoggins, Ph.D.

Undergraduate

University of Rochester (2000), Chemistry

Graduate School

Cornell University Medical Col (2007), Molecular & Cell Biology

• host-pathogen interactions
• innate immune response to viral infection
• viral pathogenesis and host genetic determinants
• virus reporters (fluorescent/luminescent) and host screening technology (CRISPR, cDNA)
• virus-host interactions; evolutionary conflicts in mammals

Featured Publications

Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.

Hanners NW, Mar KB, Boys IN, Eitson JL, De La Cruz-Rivera PC, Richardson RB, Fan W, Wight-Carter M, Schoggins JW, Proc Natl Acad Sci U S A 2021 12 118 49

TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.

Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart DJ, Lin MM, Schoggins JW, Cell 2021 Jun 184 13 3410-3425.e17

RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.

Boys IN, Xu E, Mar KB, De La Cruz-Rivera PC, Eitson JL, Moon B, Schoggins JW, Cell Host Microbe 2020 11 28 5 712-723.e9

LY6E impairs coronavirus fusion and confers immune control of viral disease.

Pfaender S, Mar KB, Michailidis E, Kratzel A, Boys IN, V'kovski P, Fan W, Kelly JN, Hirt D, Ebert N, Stalder H, Kleine-Weber H, Hoffmann M, Hoffmann HH, Saeed M, Dijkman R, Steinmann E, Wight-Carter M, McDougal MB, Hanners NW, Pöhlmann S, Gallagher T, Todt D, Zimmer G, Rice CM, Schoggins JW, Thiel V, Nat Microbiol 2020 Jul

Interferon-Stimulated Genes: What Do They All Do?

Schoggins JW, Annu Rev Virol 2019 Jul

A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication.

Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, Mar KB, De La Cruz-Rivera PC, Douglas C, Konopka G, Xing C, Schoggins JW Nat Microbiol 2018 Sep

Antithetic effect of interferon-a on cell-free and cell-to-cell HIV-1 infection.

Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson AS, Schoggins JW, Iwami S, Sato K, PLoS Comput Biol 2022 Apr 18 4 e1010053

Evolution of the interferon response: lessons from ISGs of diverse mammals.

McDougal MB, Boys IN, De La Cruz-Rivera P, Schoggins JW, Curr Opin Virol 2022 Feb 53 101202

Over-expression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.

Rinkenberger N, Abrams ME, Matta SK, Schoggins JW, Alto NM, Sibley LD, Elife 2021 Dec 10

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-?B pathway.

Khan S, Shafiei MS, Longoria C, Schoggins JW, Savani RC, Zaki H, Elife 2021 Dec 10

• NIH Director's Pioneer Award
  (2020-2025)
• American Lung Association Innovation Award
  (2019-2021)
• Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
  (2019-2024)
• The Welch Foundation Award
  (2019-2021)
• Clayton Foundation Scholar
  (2016)
• Rita Allen Foundation Scholar
  (2015-2020)
• NIH Director's New Innovator Award
  (2014-2019)
• Seymour and Vivian Milstein Young Investigator Award
  (2013)
• NIH K01 Career Development Award
  (2012-2017)
• Sidney & Joan Pestka Award for Excellence in Interferon Research
  (2011)

• American Society of Microbiology (2014)
• International Cytokine and Interferon Society (2011)
• American Society of Virology (2009)