
John Schoggins, Ph.D.
Professor
Endowed Title Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell; Tom and Charlene Marsh Family Distinguished Chair in Medicine and Science
School Medical School
Department Microbiology
Graduate Programs Immunology, Molecular Microbiology
Education
- Undergraduate
- University of Rochester (2000), Chemistry
- Graduate School
- Cornell University Medical Col (2007), Molecular & Cell Biology
Research Interest
- host-pathogen interactions
- innate immune response to viral infection
- viral pathogenesis and host genetic determinants
- virus reporters (fluorescent/luminescent) and host screening technology (CRISPR, cDNA)
- virus-host interactions; evolutionary conflicts in mammals
Publications
Featured Publications
- LY6E is a pan-coronavirus restriction factor in the respiratory tract.
- Mar KB, Wells AI, Caballero Van Dyke MC, Lopez AH, Eitson JL, Fan W, Hanners NW, Evers BM, Shelton JM, Schoggins JW, Nat Microbiol 2023 Jul
- Interferon inhibits a model RNA virus via a limited set of inducible effector genes.
- McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW, EMBO Rep 2023 Jul e56901
- Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.
- Hanners NW, Mar KB, Boys IN, Eitson JL, De La Cruz-Rivera PC, Richardson RB, Fan W, Wight-Carter M, Schoggins JW, Proc Natl Acad Sci U S A 2021 12 118 49
- TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
- Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart DJ, Lin MM, Schoggins JW, Cell 2021 Jun 184 13 3410-3425.e17
- RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.
- Boys IN, Xu E, Mar KB, De La Cruz-Rivera PC, Eitson JL, Moon B, Schoggins JW, Cell Host Microbe 2020 11 28 5 712-723.e9
- Interferon-Stimulated Genes: What Do They All Do?
- Schoggins JW, Annu Rev Virol 2019 Jul
- A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.
- Heisler DB, Johnson KA, Ma DH, Ohlson MB, Zhang L, Tran M, Corley CD, Abrams ME, McDonald JG, Schoggins JW, Alto NM, Radhakrishnan A, Elife 2023 Jan 12
- CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication.
- Rehfeld F, Eitson JL, Ohlson MB, Chang TC, Schoggins JW, Mendell JT, Cell Rep 2023 Jan 42 2 112076
- A Multi-Omics Approach Reveals Features That Permit Robust and Widespread Regulation of IFN-Inducible Antiviral Effectors.
- Göczi L, Csumita M, Horváth A, Nagy G, Póliska S, Pigni M, Thelemann C, Dániel B, Mianesaz H, Varga T, Sen K, Raghav SK, Schoggins JW, Nagy L, Acha-Orbea H, Meissner F, Reith W, Széles L, J Immunol 2022 Nov 209 10 1930-1941
- Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity.
- Fan W, McDougal MB, Schoggins JW, J Virol 2022 Sep e0133222
Honors & Awards
- NIH Director's Pioneer Award
(2020-2025) - American Lung Association Innovation Award
(2019-2021) - Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
(2019-2024) - The Welch Foundation Award
(2019-2021) - Clayton Foundation Scholar
(2016) - Rita Allen Foundation Scholar
(2015-2020) - NIH Director's New Innovator Award
(2014-2019) - Seymour and Vivian Milstein Young Investigator Award
(2013) - NIH K01 Career Development Award
(2012-2017) - Sidney & Joan Pestka Award for Excellence in Interferon Research
(2011)
Professional Associations/Affiliations
- American Society of Microbiology (2014)
- American Society of Virology (2009)
- International Cytokine and Interferon Society (2011)