
John Schoggins, Ph.D.
Associate Professor
Endowed Title Nancy Cain and Jeffrey A. Marcus Scholar in Medical Research, in Honor of Dr. Bill S. Vowell
Department Microbiology
Graduate Programs Immunology, Molecular Microbiology
Education
- Undergraduate
- University of Rochester (2000), Chemistry
- Graduate School
- Cornell University Medical Col (2007), Molecular & Cell Biology
Research Interest
- host-pathogen interactions
- innate immune response to viral infection
- viral pathogenesis and host genetic determinants
- virus reporters (fluorescent/luminescent) and host screening technology (CRISPR, cDNA)
- virus-host interactions; evolutionary conflicts in mammals
Publications
Featured Publications
- Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.
- Hanners NW, Mar KB, Boys IN, Eitson JL, De La Cruz-Rivera PC, Richardson RB, Fan W, Wight-Carter M, Schoggins JW, Proc Natl Acad Sci U S A 2021 12 118 49
- TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
- Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart DJ, Lin MM, Schoggins JW, Cell 2021 Jun 184 13 3410-3425.e17
- RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.
- Boys IN, Xu E, Mar KB, De La Cruz-Rivera PC, Eitson JL, Moon B, Schoggins JW, Cell Host Microbe 2020 11 28 5 712-723.e9
- LY6E impairs coronavirus fusion and confers immune control of viral disease.
- Pfaender S, Mar KB, Michailidis E, Kratzel A, Boys IN, V'kovski P, Fan W, Kelly JN, Hirt D, Ebert N, Stalder H, Kleine-Weber H, Hoffmann M, Hoffmann HH, Saeed M, Dijkman R, Steinmann E, Wight-Carter M, McDougal MB, Hanners NW, Pöhlmann S, Gallagher T, Todt D, Zimmer G, Rice CM, Schoggins JW, Thiel V, Nat Microbiol 2020 Jul
- Interferon-Stimulated Genes: What Do They All Do?
- Schoggins JW, Annu Rev Virol 2019 Jul
- A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication.
- Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, Mar KB, De La Cruz-Rivera PC, Douglas C, Konopka G, Xing C, Schoggins JW Nat Microbiol 2018 Sep
- Antithetic effect of interferon-a on cell-free and cell-to-cell HIV-1 infection.
- Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson AS, Schoggins JW, Iwami S, Sato K, PLoS Comput Biol 2022 Apr 18 4 e1010053
- Evolution of the interferon response: lessons from ISGs of diverse mammals.
- McDougal MB, Boys IN, De La Cruz-Rivera P, Schoggins JW, Curr Opin Virol 2022 Feb 53 101202
- Over-expression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection.
- Rinkenberger N, Abrams ME, Matta SK, Schoggins JW, Alto NM, Sibley LD, Elife 2021 Dec 10
- SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-?B pathway.
- Khan S, Shafiei MS, Longoria C, Schoggins JW, Savani RC, Zaki H, Elife 2021 Dec 10
Honors & Awards
- NIH Director's Pioneer Award
(2020-2025) - American Lung Association Innovation Award
(2019-2021) - Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
(2019-2024) - The Welch Foundation Award
(2019-2021) - Clayton Foundation Scholar
(2016) - Rita Allen Foundation Scholar
(2015-2020) - NIH Director's New Innovator Award
(2014-2019) - Seymour and Vivian Milstein Young Investigator Award
(2013) - NIH K01 Career Development Award
(2012-2017) - Sidney & Joan Pestka Award for Excellence in Interferon Research
(2011)
Professional Associations/Affiliations
- American Society of Microbiology (2014)
- International Cytokine and Interferon Society (2011)
- American Society of Virology (2009)