John Schoggins, Ph.D.

Undergraduate

University of Rochester (2000), Chemistry

Graduate School

Cornell University Medical Col (2007), Molecular & Cell Biology

• host-pathogen interactions
• innate immune response to viral infection
• viral pathogenesis and host genetic determinants
• virus reporters (fluorescent/luminescent) and host screening technology (CRISPR, cDNA)
• virus-host interactions; evolutionary conflicts in mammals

Featured Publications

LY6E is a pan-coronavirus restriction factor in the respiratory tract.

Mar KB, Wells AI, Caballero Van Dyke MC, Lopez AH, Eitson JL, Fan W, Hanners NW, Evers BM, Shelton JM, Schoggins JW, Nat Microbiol 2023 Jul

Interferon inhibits a model RNA virus via a limited set of inducible effector genes.

McDougal MB, De Maria AM, Ohlson MB, Kumar A, Xing C, Schoggins JW, EMBO Rep 2023 Jul e56901

Shiftless inhibits flavivirus replication in vitro and is neuroprotective in a mouse model of Zika virus pathogenesis.

Hanners NW, Mar KB, Boys IN, Eitson JL, De La Cruz-Rivera PC, Richardson RB, Fan W, Wight-Carter M, Schoggins JW, Proc Natl Acad Sci U S A 2021 12 118 49

TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.

Fan W, Mar KB, Sari L, Gaszek IK, Cheng Q, Evers BM, Shelton JM, Wight-Carter M, Siegwart DJ, Lin MM, Schoggins JW, Cell 2021 Jun 184 13 3410-3425.e17

RTP4 Is a Potent IFN-Inducible Anti-flavivirus Effector Engaged in a Host-Virus Arms Race in Bats and Other Mammals.

Boys IN, Xu E, Mar KB, De La Cruz-Rivera PC, Eitson JL, Moon B, Schoggins JW, Cell Host Microbe 2020 11 28 5 712-723.e9

Interferon-Stimulated Genes: What Do They All Do?

Schoggins JW, Annu Rev Virol 2019 Jul

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.

Heisler DB, Johnson KA, Ma DH, Ohlson MB, Zhang L, Tran M, Corley CD, Abrams ME, McDonald JG, Schoggins JW, Alto NM, Radhakrishnan A, Elife 2023 Jan 12

CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication.

Rehfeld F, Eitson JL, Ohlson MB, Chang TC, Schoggins JW, Mendell JT, Cell Rep 2023 Jan 42 2 112076

A Multi-Omics Approach Reveals Features That Permit Robust and Widespread Regulation of IFN-Inducible Antiviral Effectors.

Göczi L, Csumita M, Horváth A, Nagy G, Póliska S, Pigni M, Thelemann C, Dániel B, Mianesaz H, Varga T, Sen K, Raghav SK, Schoggins JW, Nagy L, Acha-Orbea H, Meissner F, Reith W, Széles L, J Immunol 2022 Nov 209 10 1930-1941

Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity.

Fan W, McDougal MB, Schoggins JW, J Virol 2022 Sep e0133222

• NIH Director's Pioneer Award
  (2020-2025)
• American Lung Association Innovation Award
  (2019-2021)
• Burroughs Wellcome Investigator in Pathogenesis of Infectious Disease
  (2019-2024)
• The Welch Foundation Award
  (2019-2021)
• Clayton Foundation Scholar
  (2016)
• Rita Allen Foundation Scholar
  (2015-2020)
• NIH Director's New Innovator Award
  (2014-2019)
• Seymour and Vivian Milstein Young Investigator Award
  (2013)
• NIH K01 Career Development Award
  (2012-2017)
• Sidney & Joan Pestka Award for Excellence in Interferon Research
  (2011)

• American Society of Microbiology (2014)
• American Society of Virology (2009)
• International Cytokine and Interferon Society (2011)