Catholic University of Louvain (1999), Cell Biology
Graduate School
Catholic University of Louvain (2006), Biomedical Studies

Research Interest

  • Cell biology - early regulation of clathrin-mediated endocytosis and general membrane traffic
  • Microscopy - state of the art live-cell imaging coupled to quantitative computer-based image analysis


Featured Publications LegendFeatured Publications

Quantification of endometriotic lesions in a murine model by fluorimetric and morphometric analyses.
Defrère S, Van Langendonckt A, González Ramos R, Jouret M, Mettlen M, Donnez J Hum. Reprod. 2006 Mar 21 3 810-7
Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend".
Emonard H, Bellon G, de Diesbach P, Mettlen M, Hornebeck W, Courtoy PJ Biochimie 2005 Mar-Apr 87 3-4 369-76
v-Src accelerates spontaneous motility via phosphoinositide 3-kinase, phospholipase C and phospholipase D, but abrogates chemotaxis in Rat-1 and MDCK cells.
Platek A, Mettlen M, Camby I, Kiss R, Amyere M, Courtoy PJ J. Cell. Sci. 2004 Sep 117 Pt 20 4849-61
Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages.
Tyteca D, Van Der Smissen P, Mettlen M, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP, Courtoy PJ Exp. Cell Res. 2002 Nov 281 1 86-100
Origin, originality, functions, subversions and molecular signalling of macropinocytosis.
Amyere M, Mettlen M, Van Der Smissen P, Platek A, Payrastre B, Veithen A, Courtoy PJ Int. J. Med. Microbiol. 2002 Feb 291 6-7 487-94

Honors & Awards

  • American Heart Association
    Postdoctoral fellowship (2006-2010)