Catholic University of Louvain (1999), Cell Biology
Graduate School
Catholic University of Louvain (2006), Biomedical Studies

Research Interest

  • Cell biology - early regulation of clathrin-mediated endocytosis and general membrane traffic
  • Microscopy - state of the art live-cell imaging coupled to quantitative computer-based image analysis


Featured Publications LegendFeatured Publications

Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources.
Nunez D, Antonescu C, Mettlen M, Liu A, Schmid SL, Loerke D, Danuser G Traffic 2011 Dec 12 12 1868-78
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis.
Mettlen M, Loerke D, Yarar D, Danuser G, Schmid SL J. Cell Biol. 2010 Mar 188 6 919-33
Dissecting dynamin's role in clathrin-mediated endocytosis.
Mettlen M, Pucadyil T, Ramachandran R, Schmid SL Biochem. Soc. Trans. 2009 Oct 37 Pt 5 1022-6
Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits.
Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL Mol. Biol. Cell 2009 Jul 20 14 3251-60
Cargo and dynamin regulate clathrin-coated pit maturation.
Loerke D, Mettlen M, Yarar D, Jaqaman K, Jaqaman H, Danuser G, Schmid SL PLoS Biol. 2009 Mar 7 3 e57
Robust single-particle tracking in live-cell time-lapse sequences.
Jaqaman K, Loerke D, Mettlen M, Kuwata H, Grinstein S, Schmid SL, Danuser G Nat. Methods 2008 Aug 5 8 695-702
Differential subcellular membrane recruitment of Src may specify its downstream signalling.
de Diesbach P, Medts T, Carpentier S, D'Auria L, Van Der Smissen P, Platek A, Mettlen M, Caplanusi A, van den Hove MF, Tyteca D, Courtoy PJ Exp. Cell Res. 2008 Apr 314 7 1465-79
Agents blocking the nuclear factor-kappaB pathway are effective inhibitors of endometriosis in an in vivo experimental model.
González-Ramos R, Van Langendonckt A, Defrère S, Lousse JC, Mettlen M, Guillet A, Donnez J Gynecol. Obstet. Invest. 2008 65 3 174-86
Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling.
Platek A, Vassilev VS, de Diesbach P, Tyteca D, Mettlen M, Courtoy PJ Exp. Cell Res. 2007 Apr 313 6 1090-105
Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells.
Mettlen M, Platek A, Van Der Smissen P, Carpentier S, Amyere M, Lanzetti L, de Diesbach P, Tyteca D, Courtoy PJ Traffic 2006 May 7 5 589-603

Honors & Awards

  • American Heart Association
    Postdoctoral fellowship (2006-2010)