Marcel Mettlen, Ph.D.

Undergraduate

Catholic University of Louvain (1999), Cell Biology

Graduate School

Catholic University of Louvain (2006), Biomedical Studies

• Cell biology - early regulation of clathrin-mediated endocytosis and general membrane traffic
• Microscopy - state of the art live-cell imaging coupled to quantitative computer-based image analysis

Featured Publications

Imaging and Modeling the Dynamics of Clathrin-Mediated Endocytosis.

Mettlen M, Danuser G Cold Spring Harb Perspect Biol 2014 Aug

Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.

Aguet F, Antonescu CN, Mettlen M, Schmid SL, Danuser G Dev. Cell 2013 Aug 26 3 279-91

Measuring the hierarchy of molecular events during clathrin-mediated endocytosis.

Loerke D, Mettlen M, Schmid SL, Danuser G Traffic 2011 Jul 12 7 815-25

Fucosylation and protein glycosylation create functional receptors for cholera toxin.

Wands AM, Fujita A, McCombs JE, Cervin J, Dedic B, Rodriguez AC, Nischan N, Bond MR, Mettlen M, Trudgian DC, Lemoff A, Quiding-Järbrink M, Gustavsson B, Steentoft C, Clausen H, Mirzaei H, Teneberg S, Yrlid U, Kohler JJ Elife 2015 Oct 4

Crosstalk between Akt/GSK3? signaling and dynamin-1 regulates clathrin-mediated endocytosis.

Reis CR, Chen PH, Srinivasan S, Aguet F, Mettlen M, Schmid SL EMBO J. 2015 Jul

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.

Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 Jun 58 5 845-53

Cell biology: Lipid switches and traffic control.

Schmid SL, Mettlen M Nature 2013 Jul 499 7457 161-2

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry.

Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG Nature 2013 Jul 499 7457 238-42

Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.

Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW Dev. Cell 2012 Aug 23 2 441-8

Structural tuning of the fluorescent protein iLOV for improved photostability.

Christie JM, Hitomi K, Arvai AS, Hartfield KA, Mettlen M, Pratt AJ, Tainer JA, Getzoff ED J. Biol. Chem. 2012 Jun 287 26 22295-304

• American Heart Association
  Postdoctoral fellowship (2006-2010)