
Marcel Mettlen, Ph.D.
Director, Quantitative Light Microscopy Core
Associate Professor
School Medical School
Department Cell Biology
Graduate Programs Cell and Molecular Biology
Biography
Education
- Undergraduate
- Catholic University of Louvain (1999), Cell Biology
- Graduate School
- Catholic University of Louvain (2006), Biomedical Studies
Research Interest
- Cell biology - early regulation of clathrin-mediated endocytosis and general membrane traffic
- Microscopy - state of the art live-cell imaging coupled to quantitative computer-based image analysis
Publications
Featured Publications
- Imaging and Modeling the Dynamics of Clathrin-Mediated Endocytosis.
- Mettlen M, Danuser G Cold Spring Harb Perspect Biol 2014 Aug
- Advances in analysis of low signal-to-noise images link dynamin and AP2 to the functions of an endocytic checkpoint.
- Aguet F, Antonescu CN, Mettlen M, Schmid SL, Danuser G Dev. Cell 2013 Aug 26 3 279-91
- Measuring the hierarchy of molecular events during clathrin-mediated endocytosis.
- Loerke D, Mettlen M, Schmid SL, Danuser G Traffic 2011 Jul 12 7 815-25
- Fucosylation and protein glycosylation create functional receptors for cholera toxin.
- Wands AM, Fujita A, McCombs JE, Cervin J, Dedic B, Rodriguez AC, Nischan N, Bond MR, Mettlen M, Trudgian DC, Lemoff A, Quiding-Järbrink M, Gustavsson B, Steentoft C, Clausen H, Mirzaei H, Teneberg S, Yrlid U, Kohler JJ Elife 2015 Oct 4
- Crosstalk between Akt/GSK3? signaling and dynamin-1 regulates clathrin-mediated endocytosis.
- Reis CR, Chen PH, Srinivasan S, Aguet F, Mettlen M, Schmid SL EMBO J. 2015 Jul
- A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome.
- Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC Mol. Cell 2015 Jun 58 5 845-53
- Cell biology: Lipid switches and traffic control.
- Schmid SL, Mettlen M Nature 2013 Jul 499 7457 161-2
- An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry.
- Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG Nature 2013 Jul 499 7457 238-42
- Context-dependent proangiogenic function of bone morphogenetic protein signaling is mediated by disabled homolog 2.
- Kim JD, Kang H, Larrivée B, Lee MY, Mettlen M, Schmid SL, Roman BL, Qyang Y, Eichmann A, Jin SW Dev. Cell 2012 Aug 23 2 441-8
- Structural tuning of the fluorescent protein iLOV for improved photostability.
- Christie JM, Hitomi K, Arvai AS, Hartfield KA, Mettlen M, Pratt AJ, Tainer JA, Getzoff ED J. Biol. Chem. 2012 Jun 287 26 22295-304
Honors & Awards
- American Heart Association
Postdoctoral fellowship (2006-2010)