Ananth Madhuranthakam, Ph.D.
Director, Mr Research
Associate Professor

Dr. Ananth Madhuranthakam received his Ph.D. in Biomedical Engineering from Mayo Clinic, Rochester, MN, where his thesis work was focused on whole-body MR angiography under the supervision of Dr. Stephen Riederer. Upon graduation, he joined the MR Research and Development division of GE Healthcare to develop novel imaging techniques to improve the clinical utility of MRI. Subsequently, he joined UT Southwestern Medical Center in 2011 as an Assistant Professor in the Department of Radiology with a secondary appointment in the Advanced Imaging Research Center (AIRC). 

Dr. Madhuranthakam’s research interests focus on understanding and applying MR Physics to exploit the variations in human anatomy and physiology. The primary areas of research include non-contrast perfusion imaging using arterial spin labeling (ASL), improved fat/water separation techniques, and whole-body MRI techniques for cancer screening and staging.

His NIH/NCI funded study is evaluating ASL as a quantiative non-contrast perfusion imaging technique for the assessment of cancer therapy response in patients with advanced brain tumors (glioblastoma) or advanced kidney cancer (metastatic renal cell carcinoma). They are evaluating this technique as part of the NCI's Quantitative Imaging Network. As part of his CPRIT funded grant, he is evaluating an efficient whole-body MRI technique that he developed in his lab for the detection and therapy response assessment in multiple myeloma and bone metastases.

Dr. Madhuranthakam has 9 patents (6 issued and 3 filed), co-authored more than 60 peer-reviewed scientific journal papers, several review articles, and more than 140 conference proceedings. He serves as a scientific reviewer for more than 10 journals including Magnetic Resonance in Medicine (MRM), Journal of Magnetic Resonance Imaging (JMRI), and Magnetic Resonance Imaging (MRI).

Dr. Madhuranthakam is also a member of the Biomedical Engineering Graduate Program at UT Southwestern Medical Center. He co-teaches Principles of MRI class and actively mentors graduate students and postdoctoral researchers in his lab. 

Undergraduate

Anna University - India (2000)

Graduate School

Mayo Graduate School (2005), Biomedical Engineering

• Arterial Spin Labeling (ASL)
• Fat/Water MR Imaging Techniques
• Non-Contrast MR Angiography/Perfusion
• Whole Body Cancer Screening and Staging

Featured Publications

Intrasession Reliability of Arterial Spin-Labeled MRI-Measured Noncontrast Perfusion in Glioblastoma at 3 T.

Zhou L, Wang Y, Pinho MC, Pan E, Xi Y, Maldjian JA, Madhuranthakam AJ, Tomography 2020 Jun 6 2 139-147

Consensus-based technical recommendations for clinical translation of renal ASL MRI.

Nery F, Buchanan CE, Harteveld AA, Odudu A, Bane O, Cox EF, Derlin K, Gach HM, Golay X, Gutberlet M, Laustsen C, Ljimani A, Madhuranthakam AJ, Pedrosa I, Prasad PV, Robson PM, Sharma K, Sourbron S, Taso M, Thomas DL, Wang DJJ, Zhang JL, Alsop DC, Fain SB, Francis ST, Fernández-Seara MA, MAGMA 2019 Dec

Robust pCASL perfusion imaging using a 3D Cartesian acquisition with spiral profile reordering (CASPR).

Greer JS, Wang X, Wang Y, Pinho MC, Maldjian JA, Pedrosa I, Madhuranthakam AJ, Magn Reson Med 2019 Jun

Insensitive Fat Suppression at 3T: Application to MR Neurography of Brachial Plexus.

Wang X, Greer JS, Dimitrov IE, Pezeshk P, Chhabra A, Madhuranthakam AJ J Magn Reson Imaging 2018 Sep

Whole-body MRI for metastatic cancer detection using T2 -weighted imaging with fat and fluid suppression.

Wang X, Pirasteh A, Brugarolas J, Rofsky NM, Lenkinski RE, Pedrosa I, Madhuranthakam AJ. Magn. Reson. Med. 2018

Quantitative Methods in Abdominal MRI: Perfusion Imaging.

Madhuranthakam AJ, Yuan Q, Pedrosa I Top Magn Reson Imaging 2017 Dec 26 6 251-258

Non-contrast quantitative pulmonary perfusion using flow alternating inversion recovery at 3T: A preliminary study.

Greer JS, Maroules CD, Oz OK, Abbara S, Peshock RM, Pedrosa I, Madhuranthakam AJ Magn Reson Imaging 2017 Nov 46 106-113

MR Neurography of Brachial Plexus at 3.0 T with Robust Fat and Blood Suppression.

Wang X, Harrison C, Mariappan YK, Gopalakrishnan K, Chhabra A, Lenkinski RE, Madhuranthakam AJ Radiology 2016 Dec 152842

Contrast-enhanced MR angiography of the peripheral vasculature with a continuously moving table and modified elliptical centric acquisition.

Madhuranthakam AJ, Hu HH, Kruger DG, Glockner JF, Riederer SJ Radiology 2006 Jul 240 1 222-9

MRI-Based Deep-Learning Method for Determining Glioma MGMT Promoter Methylation Status.

Yogananda CGB, Shah BR, Nalawade SS, Murugesan GK, Yu FF, Pinho MC, Wagner BC, Mickey B, Patel TR, Fei B, Madhuranthakam AJ, Maldjian JA, AJNR Am J Neuroradiol 2021 Mar

• Summa Cum Laude Merit Award
  International Society for Magnetic Resonance in Medicine (2017-2020)
• Magna Cum Laude Merit Awards
  International Society for Magnetic Resonance in Medicine (2016-2019)
• Distinguished Reviewer
  Journal of Magnetic Resonance Imaging (2014-2019)
• Distinguished Reviewer
  Magnetic Resonance in Medicine (2012-2019)
• ISMRM Travel Award
  Presentations at the annual scientific meetings of International Society for Magnetic Resonance in Medicine (2003-2005)
• Jawaharlal Nehru Center for Advanced Scientific Research Fellowship
  Summer Undergraduate Research Fellowship (SURF) (1999)

• American Association of Cancer Research (2020)
• American Heart Association (2013-2017)
• International Society for Magnetic Resonance in Medicine (ISMRM) (2001)