Joachim Herz graduated from Medical School at the University of Heidelberg, Germany, in 1983. He continued training as a resident in surgery in Germany and England until he joined the European Molecular Biology Laboratory in 1985. There, he received training in Molecular Biology and conducted research work that included the identification and cloning of a novel member of the LDL receptor gene family, the LDL receptor-related protein (LRP). In 1989 Dr. Herz joined the Department of Molecular Genetics where in 1998 he attained his current position of Professor. He is the holder of the Thomas O. Hicks Family Distinguished Chair in Alzheimer’s Disease Research and the Presbyterian Village North Foundation Distinguished Chair in Alzheimer's Disease Therapeutic Research.
Dr. Herz’s current research focuses on the the molecular mechanisms by which the members of the LDL receptor gene family function as signaling and endocytic receptors in the brain and in the vascular wall. Recent work from his laboratory have revealed therapeutically amenable mechanisms that can be exploited for the development of novel treatment approaches for Multiple Sclerosis and the prevention of late-onset Alzheimer's Disease.
- Medical School
- Heidelberg University (1983), Medicine
- Amyotrophic Lateral Sclerosis
- Frontotemporal Dementia
- Lipid Metabolism and Atherosclerosis
- Multiple Sclerosis
- Synaptic Physiology and Alzheimer's Disease
- Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.
- Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL, Herz J Cell Rep 2017 Sep 20 11 2565-2574
- Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.
- She A, Kurtser I, Reis SA, Hennig K, Lai J, Lang A, Zhao WN, Mazitschek R, Dickerson BC, Herz J, Haggarty SJ Cell Chem Biol 2017 Jul 24 7 892-906.e5
- A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.
- PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J J. Immunol. 2017 May 198 10 3775-3789
- News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.
- van de Sluis B, Wijers M, Herz J Curr. Opin. Lipidol. 2017 Mar
- The ApoE receptors Vldlr and Apoer2 in Central Nervous System Function and Disease.
- Lane-Donovan C, Herz J J. Lipid Res. 2017 Mar
- Imaging Subcellular Dynamics with Fast and Light-Efficient Volumetrically Parallelized Microscopy.
- Dean KM, Roudot P, Welf ES, Pohlkamp T, Garrelts G, Herz J, Fiolka R Optica 2017 Feb 4 2 263-271
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
- Lane-Donovan C, Herz J Trends Endocrinol. Metab. 2017 Jan
- NGP 555, a ?-Secretase Modulator, Lowers the Amyloid Biomarker, Aß42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.
- Kounnas MZ, Lane-Donovan C, Nowakowski DW, Herz J, Comer WT Alzheimers Dement (N Y) 2017 Jan 3 1 65-73
- Functional Roles of the Interaction of APP and Lipoprotein Receptors.
- Pohlkamp T, Wasser CR, Herz J Front Mol Neurosci 2017 10 54
- Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
- Wasser CR, Herz J J. Biol. Chem. 2016 Dec
Homologous Recombination for Gene Replacement in Mouse Cell Lines. In Methods in Cell Biology 43: Protein Expression in Animal Cells
Thomas E. Willnow and Joachim Herz (1994). San Diego, M. Roth, ed., Academic Press
Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis. In Cardiovascular Disease 94: Cellular and Molecular Mechanisms, Prevention, Treatment
Thomas E. Willnow, Shun Ishibashi and Joachim Herz (1994). New York, L. Gallo, ed., Pienum Press
Gene Inactivation by Homologous Recombination-Animal Models of Plasma Lipoprotein Disorders, Chapter 8. In Concepts in Gene Therapy
Thomas E. Willnow and Joachim Herz (1997). Berlin, New York, Michael Strauss and John Barranger, eds., Walter de Gruyter
Physiology of the LDL Receptor-Related Protein: Functions in ApoE-Mediated Remnant Metabolism and Other Biological Processes, Chapter 18. In Lipoproteins in Health and Disease
Joachim Herz (1999). London, Betteridge, Illingworth, and Shepherd, eds., Edward and Arnold
ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer's Disease. In Research and Perspectives in Alzheimer's Disease
Joachim Herz, Uwe Beffert, Thomas Hiesberger, Michael Gotthardt (2001). Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo, Beyreuther, Christensen, Masters, eds.; Springer Verlag
Lipoprotein Receptors. In Encyclopedia of Molecular Medicine
Joachim Herz (). T. Creighton, ed; John Wiley and Sons
Lipoprotein Transport. In Transgenic Models in Pharmacology, Part 4. Cardiovascular System
Hans H. Bock, Petra May, Joachim Herz (2003). Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo;, Stefan Offermanns, Lutz Hein, eds.; Springer Verlag,
Apolipoprotein E receptor 2 and very low density lipoprotein receptor: An overview.. In Fatemi, S.H. (ed), Reelin Glycoprotein, Structure, Biology and Roles in Health and Disease
Hans H. Bock and Joachim Herz (2008). New York, Springer
Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders. In Handbook of Experimental Pharmacology
Hans H. Bock and Joachim Herz, Petra May (2007). Berlin, Heidelberg, Springer-Verlag
Honors & Awards
- Harrington Innovator Award
- NIH CMND Study Section
Standing Member (2019)
- Presbyterian Village North Foundation
Distinguished Chair in Alzheimer's Disease Therapeutic Research (2017)
- NIH Merit Award
- Alexander Humboldt Foundation, Germany
Advisory Board (2014)
- Pitt-Hopkins Research Foundation
Advisory Board (2014)
- Alexander-von-Humboldt Professorship
- Heinrich-Wieland Prized
International Lipid Research Award (2007)
- Thomas O. and Cinda Hicks Family Distinguished Chair
- Wolfgang Paul Award
Humboldt Foundation of Germany (2001)
- Lucille P. Markey Scholar
- Syntex Scholar