Biography

Joachim Herz graduated from Medical School at the University of Heidelberg, Germany, in 1983. He continued training as a resident in surgery in Germany and England until he joined the European Molecular Biology Laboratory in 1985. There, he received training in Molecular Biology and conducted research work that included the identification and cloning of a novel member of the LDL receptor gene family, the LDL receptor-related protein (LRP). In 1989 Dr. Herz joined the Department of Molecular Genetics where in 1998 he attained his current position of Professor. He is the holder of the Thomas O. Hicks Family Distinguished Chair in Alzheimer’s Disease Research and the Presbyterian Village North Foundation Distinguished Chair in Alzheimer's Disease Therapeutic Research. 

Dr. Herz’s current research focuses on the the molecular mechanisms by which the members of the LDL receptor gene family function as signaling and endocytic receptors in the brain and in the vascular wall.  Recent work from his laboratory have revealed therapeutically amenable mechanisms that can be exploited for the development of novel treatment approaches for Multiple Sclerosis and the prevention of late-onset Alzheimer's Disease. 

Education

Medical School
Heidelberg University (1983), Medicine

Research Interest

  • Amyotrophic Lateral Sclerosis
  • Frontotemporal Dementia
  • Lipid Metabolism and Atherosclerosis
  • Multiple Sclerosis
  • Synaptic Physiology and Alzheimer's Disease

Publications

Featured Publications LegendFeatured Publications

How We Can Rebuild Trust in Science-And Why We Must.
Boele-Woelki K, Francisco JS, Hahn U, Herz J Angew. Chem. Int. Ed. Engl. 2018 Jul
Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.
Abou-Jaoude A, Badiqué L, Mlih M, Awan S, Guo S, Lemle A, Abboud C, Foppolo S, Host L, Terrand J, Justiniano H, Herz J, Matz RL, Boucher P Sci Rep 2018 Jun 8 1 9577
Low density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.
Hamlin AN, Chinnarasu S, Ding Y, Xian X, Herz J, Jaeschke A, Hui DY J. Biol. Chem. 2018 May
Intracellular lipid metabolism impairs ß cell compensation during diet-induced obesity.
Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE J. Clin. Invest. 2018 Mar 128 3 1178-1189
Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.
Jaoude AA, Badiqué L, Mlih M, Awan S, Guo S, Lemle A, Abboud C, Foppolo S, Host L, Terrand J, Justiniano H, Herz J, Matz RL, Boucher P Sci Rep 2018 Mar 8 1 4501
Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.
Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C Blood 2018 Mar
Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms.
Kawasaki M, Kawasaki K, Meguro F, Yamada A, Ishikawa R, Porntaveetus T, Blackburn J, Otsuka-Tanaka Y, Saito N, Ota MS, Sharpe PT, Kessler JA, Herz J, Cobourne MT, Maeda T, Ohazama A PLoS ONE 2018 13 9 e0204126
Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.
Bartelt A, Behler-Janbeck F, Beil FT, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann JP, Amling M, Herz J, Schinke T, Heeren J, Niemeier A Bone Res 2018 6 4
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.
Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J Elife 2017 Nov 6
Building a better blood-brain barrier.
Lane-Donovan C, Herz J Elife 2017 Oct 6

Books

Featured Books Legend Featured Books

Honors & Awards

  • Harrington Innovator Award
    (2019)
  • NIH CMND Study Section
    Standing Member (2019)
  • Presbyterian Village North Foundation
    Distinguished Chair in Alzheimer's Disease Therapeutic Research (2017)
  • NIH Merit Award
    (2015-2020)
  • Alexander Humboldt Foundation, Germany
    Advisory Board (2014)
  • Pitt-Hopkins Research Foundation
    Advisory Board (2014)
  • Alexander-von-Humboldt Professorship
    (2009)
  • Heinrich-Wieland Prized
    International Lipid Research Award (2007)
  • Thomas O. and Cinda Hicks Family Distinguished Chair
    (2002)
  • Wolfgang Paul Award
    Humboldt Foundation of Germany (2001)
  • Lucille P. Markey Scholar
    (1991)
  • Syntex Scholar
    (1991)