Biography

Joachim Herz graduated from Medical School at the University of Heidelberg, Germany, in 1983. He continued training as a resident in surgery in Germany and England until he joined the European Molecular Biology Laboratory in 1985. There, he received training in Molecular Biology and conducted research work that included the identification and cloning of a novel member of the LDL receptor gene family, the LDL receptor-related protein (LRP). In 1989 Dr. Herz joined the Department of Molecular Genetics where in 1998 he attained his current position of Professor. He is the holder of the Thomas O. Hicks Family Distinguished Chair in Alzheimer’s Disease Research and the Presbyterian Village North Foundation Distinguished Chair in Alzheimer's Disease Therapeutic Research. 

Dr. Herz’s current research focuses on the the molecular mechanisms by which the members of the LDL receptor gene family function as signaling and endocytic receptors in the brain and in the vascular wall.  Recent work from his laboratory have revealed therapeutically amenable mechanisms that can be exploited for the development of novel treatment approaches for Multiple Sclerosis and the prevention of late-onset Alzheimer's Disease. 

Education

Medical School
Heidelberg University (1983), Medicine

Research Interest

  • Amyotrophic Lateral Sclerosis
  • Frontotemporal Dementia
  • Lipid Metabolism and Atherosclerosis
  • Multiple Sclerosis
  • Synaptic Physiology and Alzheimer's Disease

Publications

Featured Publications LegendFeatured Publications

Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes.
Calvier L, Demuth G, Manouchehri N, Wong C, Sacharidou A, Mineo C, Shaul PW, Monson NL, Kounnas MZ, Stüve O, Herz J, Sci Transl Med 2020 Aug 12 556
Reelin signaling modulates GABAB receptor function in the neocortex.
Hamad MIK, Jbara A, Rabaya O, Petrova P, Daoud S, Melliti N, Meseke M, Lutz D, Petrasch-Parwez E, Schwitalla JC, Mark MD, Herlitze S, Reiss G, Herz J, Förster E, J. Neurochem. 2020 Feb
Biolistic transfection and expression analysis of acute cortical slices.
Hamad MIK, Daoud S, Petrova P, Rabaya O, Jbara A, Melliti N, Stichmann S, Reiss G, Herz J, Förster E, J. Neurosci. Methods 2020 Feb 337 108666
Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.
Pahle J, Muhia M, Wagener RJ, Tippmann A, Bock HH, Graw J, Herz J, Staiger JF, Drakew A, Kneussel M, Rune GM, Frotscher M, Brunne B, Cereb. Cortex 2019 Oct
Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.
Moreno-Yruela C, Fass DM, Cheng C, Herz J, Olsen CA, Haggarty SJ, ACS Chem Neurosci 2019 Jul
Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System.
Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G, PLoS Biol. 2019 Jun 17 6 e3000310
LRP1 Deficiency in Vascular SMC Leads To Pulmonary Arterial Hypertension That Is Reversed By PPAR? Activation.
Calvier L, Boucher P, Herz J, Hansmann G, Circ. Res. 2019 Apr
NGP 555, a ?-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses.
Kounnas MZ, Durakoglugil MS, Herz J, Comer WT, Alzheimers Dement (N Y) 2019 5 458-467
Reversal of ApoE4 induced recycling block as a novel prevention approach for Alzheimer's disease.
Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J Elife 2018 Oct 7
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.
Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV Mol Neurodegener 2018 10 13 1 57

Books

Featured Books Legend Featured Books

Honors & Awards

  • Harrington Innovator Award
    (2019)
  • NIH CMND Study Section
    Standing Member (2019)
  • Presbyterian Village North Foundation
    Distinguished Chair in Alzheimer's Disease Therapeutic Research (2017)
  • NIH Merit Award
    (2015-2020)
  • Alexander Humboldt Foundation, Germany
    Advisory Board (2014)
  • Pitt-Hopkins Research Foundation
    Advisory Board (2014)
  • Alexander-von-Humboldt Professorship
    (2009)
  • Heinrich-Wieland Prized
    International Lipid Research Award (2007)
  • Thomas O. and Cinda Hicks Family Distinguished Chair
    (2002)
  • Wolfgang Paul Award
    Humboldt Foundation of Germany (2001)
  • Lucille P. Markey Scholar
    (1991)
  • Syntex Scholar
    (1991)