Joachim Herz, M.D. Titles and Appointments Professor Endowed Title Presbyterian Village North Foundation Distinguished Chair in Alzheimer's Disease Therapeutic Research; Thomas O. and Cinda Hicks Family Distinguished Chair in Alzheimer's Disease Research School Medical School Department Molecular Genetics | Neurology | Neuroscience Graduate Programs Neuroscience Biography Joachim Herz graduated from Medical School at the University of Heidelberg, Germany, in 1983. He continued training as a resident in surgery in Germany and England until he joined the European Molecular Biology Laboratory in 1985. There, he received training in Molecular Biology and conducted research work that included the identification and cloning of a novel member of the LDL receptor gene family, the LDL receptor-related protein (LRP). In 1989 Dr. Herz joined the Department of Molecular Genetics where in 1998 he attained his current position of Professor. He is the holder of the Thomas O. Hicks Family Distinguished Chair in Alzheimer’s Disease Research and the Presbyterian Village North Foundation Distinguished Chair in Alzheimer's Disease Therapeutic Research. Dr. Herz’s current research focuses on the the molecular mechanisms by which the members of the LDL receptor gene family function as signaling and endocytic receptors in the brain and in the vascular wall. Recent work from his laboratory have revealed therapeutically amenable mechanisms that can be exploited for the development of novel treatment approaches for Multiple Sclerosis and the prevention of late-onset Alzheimer's Disease. Education Medical School Heidelberg University (1983), Medicine Research Interest Alzheimer's Disease Amyotrophic Lateral Sclerosis Frontotemporal Dementia Lipid Metabolism and Atherosclerosis Multiple Sclerosis Synaptic Physiology and Alzheimer's Disease Publications Featured Publications NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Pohlkamp T, Xian X, Wong CH, Durakoglugil MS, Werthmann GC, Saido TC, Evers BM, White CL, Connor J, Hammer RE, Herz J, Elife 2021 Oct 10 Reelin regulates neuronal excitability through STriatal Enriched Protein Tyrosine phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-dependent manner. Durakoglugil MS, Wasser CR, Wong CH, Pohlkamp T, Xian X, Lane-Donovan C, Fritschle K, Naestle L, Herz J, J Neurosci 2021 Jul Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes. Calvier L, Xian X, Lee R, Sacharidou A, Mineo C, Shaul PW, Kounnas MZ, Tsai S, Herz J, Arterioscler Thromb Vasc Biol 2021 Feb ATVBAHA121316000 Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes. Calvier L, Demuth G, Manouchehri N, Wong C, Sacharidou A, Mineo C, Shaul PW, Monson NL, Kounnas MZ, Stüve O, Herz J, Sci Transl Med 2020 Aug 12 556 Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency. Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL, Herz J Cell Rep 2017 Sep 20 11 2565-2574 Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improves inflammatory arthritis outcomes. Calvier L, Wasser CR, Solow EB, Wu S, Evers BM, Karp DS, Kounnas MZ, Herz J, Proc Natl Acad Sci U S A 2025 Mar 122 11 e2418642122 Apoer2/Lrp8: the undercover cop of synaptic homeostasis. Werthmann GC, Herz J, Neural Regen Res 2024 Dec 19 12 2563-2564 Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling. Guo X, Yang F, Liu T, Chen A, Liu D, Pu J, Jia C, Wu Y, Yuan J, Ouyang N, Herz J, Ding Y, Adv Sci (Weinh) 2024 Oct e2401672 Correction: LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J, Elife 2024 Oct 13 Reelin differentially shapes dendrite morphology of medial entorhinal cortical ocean and island cells. Hamad MIK, Daoud S, Petrova P, Rabaya O, Jbara A, Al Houqani S, BaniYas S, Alblooshi M, Almheiri A, Nakhal MM, Ali BR, Shehab S, Allouh MZ, Emerald BS, Schneider-Lódi M, Bataineh MF, Herz J, Förster E, Development 2024 Jul 151 13 Results 1-10 of 312 1 2 3 4 5 Next Last Books Featured Books Homologous Recombination for Gene Replacement in Mouse Cell Lines. In Methods in Cell Biology 43: Protein Expression in Animal Cells Thomas E. Willnow and Joachim Herz (1994). San Diego, M. Roth, ed., Academic Press Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis. In Cardiovascular Disease 94: Cellular and Molecular Mechanisms, Prevention, Treatment Thomas E. Willnow, Shun Ishibashi and Joachim Herz (1994). New York, L. Gallo, ed., Pienum Press Gene Inactivation by Homologous Recombination-Animal Models of Plasma Lipoprotein Disorders, Chapter 8. In Concepts in Gene Therapy Thomas E. Willnow and Joachim Herz (1997). Berlin, New York, Michael Strauss and John Barranger, eds., Walter de Gruyter Physiology of the LDL Receptor-Related Protein: Functions in ApoE-Mediated Remnant Metabolism and Other Biological Processes, Chapter 18. In Lipoproteins in Health and Disease Joachim Herz (1999). London, Betteridge, Illingworth, and Shepherd, eds., Edward and Arnold ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer's Disease. In Research and Perspectives in Alzheimer's Disease Joachim Herz, Uwe Beffert, Thomas Hiesberger, Michael Gotthardt (2001). Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo, Beyreuther, Christensen, Masters, eds.; Springer Verlag Lipoprotein Receptors. In Encyclopedia of Molecular Medicine Joachim Herz (). T. Creighton, ed; John Wiley and Sons Lipoprotein Transport. In Transgenic Models in Pharmacology, Part 4. Cardiovascular System Hans H. Bock, Petra May, Joachim Herz (2003). Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo;, Stefan Offermanns, Lutz Hein, eds.; Springer Verlag, Apolipoprotein E receptor 2 and very low density lipoprotein receptor: An overview.. In Fatemi, S.H. (ed), Reelin Glycoprotein, Structure, Biology and Roles in Health and Disease Hans H. Bock and Joachim Herz (2008). New York, Springer Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders. In Handbook of Experimental Pharmacology Hans H. Bock and Joachim Herz, Petra May (2007). Berlin, Heidelberg, Springer-Verlag Honors & Awards Harrington Innovator Award (2019) NIH CMND Study SectionStanding Member (2019) Presbyterian Village North FoundationDistinguished Chair in Alzheimer's Disease Therapeutic Research (2017) NIH Merit Award (2015-2020) Alexander Humboldt Foundation, GermanyAdvisory Board (2014) Pitt-Hopkins Research FoundationAdvisory Board (2014) Alexander-von-Humboldt Professorship (2009) Heinrich-Wieland PrizedInternational Lipid Research Award (2007) Thomas O. and Cinda Hicks Family Distinguished Chair (2002) Wolfgang Paul AwardHumboldt Foundation of Germany (2001) Lucille P. Markey Scholar (1991) Syntex Scholar (1991)
