Joachim Herz graduated from Medical School at the University of Heidelberg, Germany, in 1983. He continued training as a resident in surgery in Germany and England until he joined the European Molecular Biology Laboratory in 1985. There, he received training in Molecular Biology and conducted research work that included the identification and cloning of a novel member of the LDL receptor gene family, the LDL receptor-related protein (LRP). In 1989 Dr. Herz joined the Department of Molecular Genetics where in 1998 he attained his current position of Professor. He is the holder of the Thomas O. Hicks Family Distinguished Chair in Alzheimer’s Disease Research.

Dr. Herz’s current research focuses on the role of the members of the LDL receptor gene family as signaling receptors in the brain and in the vascular wall. Recent work from his laboratory have defined roles for the LDL receptor gene family in the formation of the mammalian brain, where it regulates the migration and positioning of neurons during embryonic development, and control of vascular wall integrity, where the LRP functions in conjunction with the PDGF receptor.


Medical School
Heidelberg University (1983), Medicine

Research Interest

  • Brain Development and Alzheimer's Disease
  • Lipid Metabolism and Atherosclerosis
  • Physiological functions of the LDL receptor gene family


Featured Publications LegendFeatured Publications

LRP1 Deficiency in Vascular SMC Leads To Pulmonary Arterial Hypertension That Is Reversed By PPAR? Activation.
Calvier L, Boucher P, Herz J, Hansmann G, Circ. Res. 2019 Apr
Reversal of ApoE4 induced recycling block as a novel prevention approach for Alzheimer's disease.
Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J Elife 2018 Oct 7
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Meseke M, Neumüller F, Brunne B, Li X, Anstötz M, Pohlkamp T, Rogalla MM, Herz J, Rune GM, Bender RA eNeuro 2018 Sep-Oct 5 5
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.
Xian X, Ding Y, Dieckmann M, Zhou L, Plattner F, Liu M, Parks JS, Hammer RE, Boucher P, Tsai S, Herz J Elife 2017 Nov 6

Honors & Awards

  • Alexander-von-Humboldt Professorship
  • Heinrich-Wieland Prized
    International Lipid Research Award (2007)
  • Thomas O. and Cinda Hicks Family Distinguished Chair
  • Wolfgang Paul Award
    Humboldt Foundation of Germany (2001)
  • Lucille P. Markey Scholar
  • Syntex Scholar