Joachim Herz graduated from Medical School at the University of Heidelberg, Germany, in 1983. He continued training as a resident in surgery in Germany and England until he joined the European Molecular Biology Laboratory in 1985. There, he received training in Molecular Biology and conducted research work that included the identification and cloning of a novel member of the LDL receptor gene family, the LDL receptor-related protein (LRP). In 1989 Dr. Herz joined the Department of Molecular Genetics where in 1998 he attained his current position of Professor. He is the holder of the Thomas O. Hicks Family Distinguished Chair in Alzheimer’s Disease Research and the Presbyterian Village North Foundation Distinguished Chair in Alzheimer's Disease Therapeutic Research.
Dr. Herz’s current research focuses on the the molecular mechanisms by which the members of the LDL receptor gene family function as signaling and endocytic receptors in the brain and in the vascular wall. Recent work from his laboratory have revealed therapeutically amenable mechanisms that can be exploited for the development of novel treatment approaches for Multiple Sclerosis and the prevention of late-onset Alzheimer's Disease.
- Medical School
- Heidelberg University (1983), Medicine
- Amyotrophic Lateral Sclerosis
- Frontotemporal Dementia
- Lipid Metabolism and Atherosclerosis
- Multiple Sclerosis
- Synaptic Physiology and Alzheimer's Disease
- Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes.
- Calvier L, Demuth G, Manouchehri N, Wong C, Sacharidou A, Mineo C, Shaul PW, Monson NL, Kounnas MZ, Stüve O, Herz J, Sci Transl Med 2020 Aug 12 556
- Reelin signaling modulates GABAB receptor function in the neocortex.
- Hamad MIK, Jbara A, Rabaya O, Petrova P, Daoud S, Melliti N, Meseke M, Lutz D, Petrasch-Parwez E, Schwitalla JC, Mark MD, Herlitze S, Reiss G, Herz J, Förster E, J. Neurochem. 2020 Feb
- Biolistic transfection and expression analysis of acute cortical slices.
- Hamad MIK, Daoud S, Petrova P, Rabaya O, Jbara A, Melliti N, Stichmann S, Reiss G, Herz J, Förster E, J. Neurosci. Methods 2020 Feb 337 108666
- Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.
- Pahle J, Muhia M, Wagener RJ, Tippmann A, Bock HH, Graw J, Herz J, Staiger JF, Drakew A, Kneussel M, Rune GM, Frotscher M, Brunne B, Cereb. Cortex 2019 Oct
- Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.
- Moreno-Yruela C, Fass DM, Cheng C, Herz J, Olsen CA, Haggarty SJ, ACS Chem Neurosci 2019 Jul
- Correction: Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System.
- Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G, PLoS Biol. 2019 Jun 17 6 e3000310
- LRP1 Deficiency in Vascular SMC Leads To Pulmonary Arterial Hypertension That Is Reversed By PPAR? Activation.
- Calvier L, Boucher P, Herz J, Hansmann G, Circ. Res. 2019 Apr
- NGP 555, a ?-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses.
- Kounnas MZ, Durakoglugil MS, Herz J, Comer WT, Alzheimers Dement (N Y) 2019 5 458-467
- Reversal of ApoE4 induced recycling block as a novel prevention approach for Alzheimer's disease.
- Xian X, Pohlkamp T, Durakoglugil MS, Wong CH, Beck JK, Lane-Donovan C, Plattner F, Herz J Elife 2018 Oct 7
- Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.
- Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV Mol Neurodegener 2018 10 13 1 57
Homologous Recombination for Gene Replacement in Mouse Cell Lines. In Methods in Cell Biology 43: Protein Expression in Animal Cells
Thomas E. Willnow and Joachim Herz (1994). San Diego, M. Roth, ed., Academic Press
Genetic Manipulation of Lipoprotein Receptors: Implications for Lipid Metabolism and Atherosclerosis. In Cardiovascular Disease 94: Cellular and Molecular Mechanisms, Prevention, Treatment
Thomas E. Willnow, Shun Ishibashi and Joachim Herz (1994). New York, L. Gallo, ed., Pienum Press
Gene Inactivation by Homologous Recombination-Animal Models of Plasma Lipoprotein Disorders, Chapter 8. In Concepts in Gene Therapy
Thomas E. Willnow and Joachim Herz (1997). Berlin, New York, Michael Strauss and John Barranger, eds., Walter de Gruyter
Physiology of the LDL Receptor-Related Protein: Functions in ApoE-Mediated Remnant Metabolism and Other Biological Processes, Chapter 18. In Lipoproteins in Health and Disease
Joachim Herz (1999). London, Betteridge, Illingworth, and Shepherd, eds., Edward and Arnold
ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer's Disease. In Research and Perspectives in Alzheimer's Disease
Joachim Herz, Uwe Beffert, Thomas Hiesberger, Michael Gotthardt (2001). Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo, Beyreuther, Christensen, Masters, eds.; Springer Verlag
Lipoprotein Receptors. In Encyclopedia of Molecular Medicine
Joachim Herz (). T. Creighton, ed; John Wiley and Sons
Lipoprotein Transport. In Transgenic Models in Pharmacology, Part 4. Cardiovascular System
Hans H. Bock, Petra May, Joachim Herz (2003). Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo;, Stefan Offermanns, Lutz Hein, eds.; Springer Verlag,
Apolipoprotein E receptor 2 and very low density lipoprotein receptor: An overview.. In Fatemi, S.H. (ed), Reelin Glycoprotein, Structure, Biology and Roles in Health and Disease
Hans H. Bock and Joachim Herz (2008). New York, Springer
Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders. In Handbook of Experimental Pharmacology
Hans H. Bock and Joachim Herz, Petra May (2007). Berlin, Heidelberg, Springer-Verlag
Honors & Awards
- Harrington Innovator Award
- NIH CMND Study Section
Standing Member (2019)
- Presbyterian Village North Foundation
Distinguished Chair in Alzheimer's Disease Therapeutic Research (2017)
- NIH Merit Award
- Alexander Humboldt Foundation, Germany
Advisory Board (2014)
- Pitt-Hopkins Research Foundation
Advisory Board (2014)
- Alexander-von-Humboldt Professorship
- Heinrich-Wieland Prized
International Lipid Research Award (2007)
- Thomas O. and Cinda Hicks Family Distinguished Chair
- Wolfgang Paul Award
Humboldt Foundation of Germany (2001)
- Lucille P. Markey Scholar
- Syntex Scholar