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Sandra Schmid was born in Vancouver, Canada and received her B.Sc. Degree (Honours) in Cell Biology at the University of British Columbia.  She moved to the U.S. in 1980 for graduate studies with Jim Rothman at Stanford University. She was a Helen Hay Whitney postdoctoral fellow and Lucille P. Markey Scholar with Ira Mellman and Ari Helenius at Yale, and moved to The Scripps Research Institute as an Assistant Professor in 1988. She served as Chairman of the Department of Cell Biology at TSRI from 2000-2012, before being recruited to UTSW. Schmid is a leader in the scientific community.  She was co-founding editor of Traffic, Editor-in-Chief of Molecular Biology of the Cell and President of the American Society for Cell Biology. She has received numerous awards, including an ASCB/WICB Jr. Career Recognition Award, an NIH MERIT Award and the William C. Rose Award from the ASBMB. Schmid is committed to mentoring young scientists and gives frequent career development and time management seminars to postdoctoral fellows and junior faculty throughout the US. As a mother of two, now college-aged children, she remembers fondly coaching their soccer teams, going on family RV trips and attending their recitals.  Schmid's research, published in >130 papers, is directed towards elucidating the molecular mechanisms and regulation of clathrin-mediated endocytosis, and analyzing the structure and function of the GTPase, dynamin. 


University of British Columbia (1980), Cell Biology
Graduate School
Stanford University (1985), Biochemistry
Graduate School
University of San Diego (2009)

Research Interest

  • Differential regulation of CME in normal and cancer cells
  • Mechanisms governing and regulating clathrin-mediated endocytosis
  • Structure and Function of the GTPase Dynamin


Featured Publications LegendFeatured Publications

Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint.
Aguet F, Antonescu CN, Mettlen M, Schmid SL, Danuser G Dev. Cell 2013 Jul
Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.
Liu YW, Neumann S, Ramachandran R, Ferguson SM, Pucadyil TJ, Schmid SL Proc. Natl. Acad. Sci. U.S.A. 2011 Jun 108 26 E234-42
Dynamin: functional design of a membrane fission catalyst.
Schmid SL, Frolov VA Annu. Rev. Cell Dev. Biol. 2011 27 79-105
G domain dimerization controls dynamin's assembly-stimulated GTPase activity.
Chappie JS, Acharya S, Leonard M, Schmid SL, Dyda F Nature 2010 May 465 7297 435-40
Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis.
Mettlen M, Loerke D, Yarar D, Danuser G, Schmid SL J. Cell Biol. 2010 Mar 188 6 919-33
Conserved functions of membrane active GTPases in coated vesicle formation.
Pucadyil TJ, Schmid SL Science 2009 Sep 325 5945 1217-20
Cargo and dynamin regulate clathrin-coated pit maturation.
Loerke D, Mettlen M, Yarar D, Jaqaman K, Jaqaman H, Danuser G, Schmid SL PLoS Biol. 2009 Mar 7 3 e57
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release.
Pucadyil TJ, Schmid SL Cell 2008 Dec 135 7 1263-75
Regulated portals of entry into the cell.
Conner SD, Schmid SL Nature 2003 Mar 422 6927 37-44
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis.
Conner SD, Schmid SL J. Cell Biol. 2002 Mar 156 5 921-9

Honors & Awards

  • American Academy of Arts and Sciences
  • Sir Bernard Katz Award, Biophysics Society
  • Sr. Leadership Award, ASCB Women in Cell Biology
  • ASBMB William Rose Award
  • NIH MERIT Award

Professional Associations/Affiliations

  • Jane Coffin Childs, Scientific Advisory Board (2017)
  • Pew Scholars Advisory Committee (2017)
  • Academic Editor, PLoS Biology (2011)
  • President-Elect, President, Past President, ASCB (2010-2012)