Sandra Schmid was born in Vancouver, Canada and received her B.Sc. Degree (Honours) in Cell Biology at the University of British Columbia. She moved to the U.S. in 1980 for graduate studies with Jim Rothman at Stanford University. She was a Helen Hay Whitney postdoctoral fellow and Lucille P. Markey Scholar with Ira Mellman and Ari Helenius at Yale, and moved to The Scripps Research Institute as an Assistant Professor in 1988. She served as Chairman of the Department of Cell Biology at TSRI from 2000-2012, before being recruited to UTSW. Schmid is a leader in the scientific community. She was co-founding editor of Traffic, Editor-in-Chief of Molecular Biology of the Cell and President of the American Society for Cell Biology. She has received numerous awards, including an ASCB/WICB Jr. Career Recognition Award, an NIH MERIT Award and the William C. Rose Award from the ASBMB. Schmid is committed to mentoring young scientists and gives frequent career development and time management seminars to postdoctoral fellows and junior faculty throughout the US. As a mother of two, now college-aged children, she remembers fondly coaching their soccer teams, going on family RV trips and attending their recitals. Schmid's research, published in >130 papers, is directed towards elucidating the molecular mechanisms and regulation of clathrin-mediated endocytosis, and analyzing the structure and function of the GTPase, dynamin.
- University of British Columbia (1980), Cell Biology
- Graduate School
- Stanford University (1985), Biochemistry
- Graduate School
- University of San Diego (2009)
- Differential regulation of CME in normal and cancer cells
- Mechanisms governing and regulating clathrin-mediated endocytosis
- Structure and Function of the GTPase Dynamin
- Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell.
- Schmid SL J. Cell Biol. 2017 Jul
- Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis.
- Chen PH, Bendris N, Hsiao YJ, Reis CR, Mettlen M, Chen HY, Yu SL, Schmid SL Dev. Cell 2017 Feb 40 3 278-288.e5
- Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.
- Kadlecova Z, Spielman SJ, Loerke D, Mohanakrishnan A, Reed DK, Schmid SL J. Cell Biol. 2016 Dec
- Crosstalk between Akt/GSK3ß signaling and dynamin-1 regulates clathrin-mediated endocytosis.
- Reis CR, Chen PH, Srinivasan S, Aguet F, Mettlen M, Schmid SL EMBO J. 2015 Jul
- A hemi-fission intermediate links two mechanistically distinct stages of membrane fission.
- Mattila JP, Shnyrova AV, Sundborger AC, Hortelano ER, Fuhrmans M, Neumann S, Müller M, Hinshaw JE, Schmid SL, Frolov VA Nature 2015 Jun
- A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.
- Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F Cell 2011 Sep 147 1 209-22
- TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation.
- Reis CR, Chen PH, Bendris N, Schmid SL Proc. Natl. Acad. Sci. U.S.A. 2017 Jan 114 3 504-509
- SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases.
- Bendris N, Williams KC, Reis CR, Welf ES, Chen PH, Lemmers B, Hahne M, Leong HS, Schmid SL Mol. Biol. Cell 2016 Mar
- Identification and function of conformational dynamics in the multidomain GTPase dynamin.
- Srinivasan S, Dharmarajan V, Reed DK, Griffin PR, Schmid SL EMBO J. 2016 Jan
- A systematic analysis reveals heterogeneous changes in the endocytic activities of cancer cells.
- Elkin SR, Bendris N, Reis C, Zhou Y, Xie Y, Huffman KE, Minna JD, Schmid SL Cancer Res. 2015 Sep
Honors & Awards
- American Academy of Arts and Sciences
- Sir Bernard Katz Award, Biophysics Society
- Sr. Leadership Award, ASCB Women in Cell Biology
- ASBMB William Rose Award
- NIH MERIT Award
- Jane Coffin Childs, Scientific Advisory Board (2017)
- Pew Scholars Advisory Committee (2017)
- Academic Editor, PLoS Biology (2011)
- President-Elect, President, Past President, ASCB (2010-2012)