Ruth Gordillo, Ph.D.
Associate Professor

Dr. Gordillo was born in Badajoz, Spain. She earned her B.S. and Ph.D. degrees in Chemistry from the University of Extremadura (Spain) in 1997 and 2002, respectively. She specializes in the development of LC/MS/MS technologies for the determination and quantification of metabolites.

She is the Director of UTSW Metabolic Phenotyping Core. The Core provides comprehensive, state-of-the-art measurements of multiple parameters, including: mass spectrometry, physiology, lipid, glucose, and metabokine assays to investigators at UTSWMC. In this way the scientific community has available a centralized service that is more cost effective preventing the duplication of reagents and instrumentation providing consistency in various assays across laboratories. The services are offered to investigators inside and outside UTSW campus. Dr. Gordillo is responsible for the daily operations of the core, interacting with users, experiment design and technical consultation services are part of her mission as director of the facility. Throughout the years, she has acquired hands on experience on all the instrumentation under the core management. She also has several years of industry expertise in the area of mass spectrometry analysis of endogenous and drug metabolites in biological samples.

 
UT Southwestern Metabolic Core URL https://touchstonelabs.org/metabolic-phenotyping-core/
UT Southwestern Touchstone Diabetes Center URL https://touchstonelabs.org/

Expertise:
Mass Spectrometry
Bioanalytical Chemistry
Drug Discovery
Metabolomics
LC-TOF
Triple Quadrupole
Tandem LC-MS/MS
Tissue sample preparation
Biological fluids sample preparation
Liquid-liquid extraction
Solid phase extraction (SPE)
Culture of human cancer cell lines

Undergraduate

Universidad De Extremadura (1997), Chemistry

Graduate School

Universidad De Extremadura (1998), Chemistry

Graduate School

Universidad De Extremadura (2002), Science

• Lipidomics
• Mass Spectrometry
• Metabolomics
• Pharmacodynamics
• Pharmacokinetics

Featured Publications

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.

Crewe C, Joffin N, Rutkowski JM, Kim M, Zhang F, Towler DA, Gordillo R, Scherer PE Cell 2018 Oct 175 3 695-708.e13

Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis.

Apostolopoulou M, Gordillo R, Koliaki C, Gancheva S, Jelenik T, De Filippo E, Herder C, Markgraf D, Jankowiak F, Esposito I, Schlensak M, Scherer PE, Roden M Diabetes Care 2018 Mar

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.

Deng Y, Wang ZV, Gordillo R, Zhu Y, Ali A, Zhang C, Wang X, Shao M, Zhang Z, Iyengar P, Gupta RK, Horton JD, Hill JA, Scherer PE Mol Metab 2018 Mar

Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.

Xia JY, Sun K, Hepler C, Ghaben AL, Gupta RK, An YA, Holland WL, Morley TS, Adams AC, Gordillo R, Kusminski CM, Scherer PE Diabetologia 2017 Dec

An adipo-biliary-uridine axis that regulates energy homeostasis.

Deng Y, Wang ZV, Gordillo R, An Y, Zhang C, Liang Q, Yoshino J, Cautivo KM, De Brabander J, Elmquist JK, Horton JD, Hill JA, Klein S, Scherer PE Science 2017 Mar 355 6330

Plasma ceramides are elevated in female children and adolescents with type 2 diabetes.

Lopez X, Goldfine AB, Holland WL, Gordillo R, Scherer PE J. Pediatr. Endocrinol. Metab. 2013 Apr 1-4

• Outstanding Thesis Award
  University of Extremadura (Spain) (2002)
• Postdoctoral Fellowship
  University of Extremadura (Spain) (2002)
• Postdoctoral Fellowship
  Government of Spain (2002)
• Predoctoral Scholarship
  Government of Spain (1998)
• Visitor Research Scholarship
  Government of Spain (1998)

• Sociedad Española de Espectrometría de Masas (2013)
• American Society for Mass Spectrometry (2005)
• American Chemical Society (2003)