Robert Hammer, Ph.D.

• Genome editing and transgenesis
• Oncogene and nutrient collaboration in cancer
• Ribosomopathies
• Rodent models of cancer

 Featured Publications

Differential requirements for cell-specific elastase I enhancer domains in transfected cells and transgenic mice.

Swift, G. H., Kruse, F., MacDonald, R.J., and Hammer, R.E. Genes and Dev. 1998 3 687-696.

Germline intrachromosomal recombination restores fertility in transgenic Myk-103 male mice.

Wilkie, T. M., Braun, R.E. Ehrman, W.J., Palmiter, R.D., and Hammer, R.E. Genes and Dev. 1991 5 38-48.

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders.

Hammer, R.E., Maika, S.D., Richardson, J.A., Tang, J.P., and Taurog, J.D. Cell 1990 63 1099-1112

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.

Hofmann, S.L., Russell, D.W., Brown, M.S., Goldstein, J.L., and Hammer, R.E. Science 1988 239 1277-1281

Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth.

Hammer, R.E., Brinster, R.L., Rosenfeld, M.G., Evans, R.M., and Mayo, K.E. Nature 1985 315 413-416

Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.

Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.E., Rosenfeld, M.G., Birnberg, N.C., and Evans, R.M. Nature 1982 300 611-615

Hepatoblastoma modeling in mice places nrf2 within a cancer field established by mutant ?-catenin.

Comerford SA, Hinnant EA, Chen Y, Bansal H, Klapproth S, Rakheja D, Finegold MJ, Lopez-Terrada D, O?Donnell KA, Tomlinson GE, Hammer RE. J Clin Invest Insight. 2016 16 e88549.

Acetate dependence of tumors.

Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz A, Walters H, Tantawy MN, Fu A, Manning C, Horton JD, Hammer RE, McKnight SL, Tu BP Cell. 2014 159 1591-1602

Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver.

Comerford SA, Schultz N, Hinnant EA, Klapproth S, Hammer RE Oncogenesis 2012 1 e28

Induction of hepatocyte proliferation and death by modulation of T-Antigen expression.

Comerford, S.A., Clouthier, D.E., Hinnant, E., and Hammer, R.E. Oncogene 2003 22 2515-2530

• State Capital of Wiesbaden, Germany
  Carol-Nachman Prize in Rheumatology (1992)
• USDA Unit Award for Distinguished Service
  Application of Gene Transfer to Farm Animals (1989)
• University of Pennsylvania School of Veterinary Medicine
  NIH Postdoctoral Fellowship (1983)

• International Society for Stem Cell Research (ISSCR) (2018)
• International Society of Transgenic Technology (ISTT) (2010)
• Public Responsibility in Medicine and Research (PRIMR) (2016)
• Society for Developmental Biology (2020)