Matthew Mitsche, Ph.D. Assistant Professor School Medical School Department Center for Human Nutrition | Internal Medicine Biography Download Curriculum Vitae Dr. Mitsche's studies lipid physiology using mass spectrometry and stable isotope labeling. We focus on mouse models of fatty liver disease and cardiovascular disease. He has also focused on sterol metabolism and apolipoprotein surface chemistry. Dr. Mitsche has a BS in Chemical Engineering from the University of Delaware, PhD in Physiology and Biophysics from Boston University, and did his post-doctoral fellowship at the University of Texas Southwestern Medical Center with Drs Hobbs and Cohen. Education Undergraduate University of Delaware (2006), Chemical Engineering Graduate School Boston University (2012), Biophysics Research Interest Cardiovascular Disease Fatty Liver Disease Lipid Flux Analysis Lipid Physiology Lipid Surface Chemisry Lipidomics Sterol Biosynthesis Publications Featured Publications Phospholipase Domain-containing Protein 3 Promotes Transfers of Essential Fatty Acids from Triglycerides to Phospholipids in Hepatic Lipid Droplets. Mitsche MA, Hobbs HH, Cohen JC J. Biol. Chem. 2018 Mar Relative roles of ABCG5/ABCG8 in liver and intestine. Wang J, Mitsche MA, Lütjohann D, Cohen JC, Xie XS, Hobbs HH J. Lipid Res. 2015 Feb 56 2 319-30 Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly. Mitsche MA, Packer LE, Brown JW, Jiang ZG, Small DM, McKnight CJ J. Biol. Chem. 2014 Mar 289 13 9000-12 Surface pressure-dependent conformation change of apolipoprotein-derived amphipathic a-helices. Mitsche MA, Small DM J. Lipid Res. 2013 Jun 54 6 1578-88 C-terminus of apolipoprotein A-I removes phospholipids from a triolein/phospholipids/water interface, but the N-terminus does not: a possible mechanism for nascent HDL assembly. Mitsche MA, Small DM Biophys. J. 2011 Jul 101 2 353-61 Three Phase Liquid Extraction (3PLE): A Simple, and Fast Method for Lipidomic Workflows. Vale G, Martin SA, Mitsche MA, Thompson BM, Eckert KM, McDonald JG J. Lipid Res. 2019 Jan Patatin-like phospholipase domain-containing protein 3 promotes transfer of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets. Mitsche MA, Hobbs HH, Cohen JC J. Biol. Chem. 2018 06 293 24 9232 Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI. Zhang Y, Udayakumar D, Cai L, Hu Z, Kapur P, Kho EY, Pavía-Jiménez A, Fulkerson M, de Leon AD, Yuan Q, Dimitrov IE, Yokoo T, Ye J, Mitsche MA, Kim H, McDonald JG, Xi Y, Madhuranthakam AJ, Dwivedi DK, Lenkinski RE, Cadeddu JA, Margulis V, Brugarolas J, DeBerardinis RJ, Pedrosa I JCI Insight 2017 Aug 2 15 Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver. Hwang S, Hartman IZ, Calhoun LN, Garland K, Young GA, Mitsche MA, McDonald J, Xu F, Engelking L, DeBose-Boyd RA J. Biol. Chem. 2016 Jun 291 26 13479-94 Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu J, O'Malley BW, Mendelson CR J. Clin. Invest. 2015 Jul 125 7 2808-24 Results 1-10 of 14 1 2 Next Last Professional Associations/Affiliations Matthew Mitsche (2017)
