Nick Grishin, Ph.D. Titles and Appointments Professor Endowed Title Cecil H. and Ida M. Green Chair in Biomedical Science; Virginia Murchison Linthicum Scholar in Biomedical Research School Medical School Department Biophysics | Biochemistry Graduate Programs Molecular Biophysics Biography Dr. Grishin is HHMI Investigator and Professor of Biochemistry at UT Southwestern. Born and educated in Russia, he received a Diplom (the Russian equivalent of a master’s degree) in biochemistry from the Moscow State University. His doctoral research in molecular biophysics was done with Margaret Phillips at UT Southwestern. After a postdoctoral year with Eugene Koonin at the National Institutes of Health, he joined the faculty at UT Southwestern. Education Graduate School Moscow State University - Russ (1993) Graduate School UT Southwestern Medical Center (1998) Research Interest We study proteins by means of computational methods Publications Featured Publications PROMALS: towards accurate multiple sequence alignments of distantly related proteins. Pei J, Grishin NV. Bioinformatics January 2007 23(7) 802-808 Protein structure prediction for the male-specific region of the human Y chromosome. Ginalski K, Rychlewski L, Baker D, Grishin NV. Proc Natl Acad Sci U S A February 2004 101(8) 2305-2310 COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance. Sadreyev R, Grishin NV J Mol Biol February 2003 326(1) 317-336 Sequence and structure classification of kinases. Cheek S, Zhang H, Grishin NV. J Mol Biol July 2002 320(4) 855-881 Fold change in evolution of protein structures. Grishin, N.V. J. Struct. Biol. 2001 134 167-185 A comprehensive system for evaluation of remote sequence similarity detection Qi Y, Sadreyev RI, Wang Y, Kim BH, Grishin NV. BMC Bioinformatics August 2007 8(1) 314 Searching for three-dimensional secondary structural patterns in proteins with ProSMoS. Shi S, Zhong Y, Majumdar I, Sri Krishna S, Grishin NV. Bioinformatics June 2007 23(11) 1331-1338 COMPASS server for remote homology inference Sadreyev RI, Tang M, Kim BH, Grishin NV. Nucleic Acids Res May 2007 35(Web Server issue) W653 MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information. Pei J, Grishin NV. Nucleic Acids Res August 2006 34(16) 4364-4374 Structural classification of small, disulfide-rich protein domains. Cheek S, Krishna SS, Grishin NV. J Mol Biol. May 2006 359(1) 215-237 Results 1-10 of 10 1 Honors & Awards Finn World Travel Awardto attend 12th Symposium of the Protein Society (1998) UT Southwestern Graduate SchoolNominata Award (1998) Department of PharmacologyA.G. Gilman award for excellence in research (1997) GSO Travel Awardto attend XVII Congress of Intl. Union of Crystallography (1996)
