Nick Grishin, Ph.D.

Dr. Grishin is HHMI Investigator and Professor of Biochemistry at UT Southwestern. Born and educated in Russia, he received a Diplom (the Russian equivalent of a master’s degree) in biochemistry from the Moscow State University. His doctoral research in molecular biophysics was done with Margaret Phillips at UT Southwestern. After a postdoctoral year with Eugene Koonin at the National Institutes of Health, he joined the faculty at UT Southwestern.

Graduate School

Moscow State University - Russ (1993)

Graduate School

UT Southwestern Medical Center (1998)

• We study proteins by means of computational methods

Featured Publications

PROMALS: towards accurate multiple sequence alignments of distantly related proteins.

Pei J, Grishin NV. Bioinformatics January 2007 23(7) 802-808

Protein structure prediction for the male-specific region of the human Y chromosome.

Ginalski K, Rychlewski L, Baker D, Grishin NV. Proc Natl Acad Sci U S A February 2004 101(8) 2305-2310

COMPASS: a tool for comparison of multiple protein alignments with assessment of statistical significance.

Sadreyev R, Grishin NV J Mol Biol February 2003 326(1) 317-336

Sequence and structure classification of kinases.

Cheek S, Zhang H, Grishin NV. J Mol Biol July 2002 320(4) 855-881

Fold change in evolution of protein structures.

Grishin, N.V. J. Struct. Biol. 2001 134 167-185

A comprehensive system for evaluation of remote sequence similarity detection

Qi Y, Sadreyev RI, Wang Y, Kim BH, Grishin NV. BMC Bioinformatics August 2007 8(1) 314

Searching for three-dimensional secondary structural patterns in proteins with ProSMoS.

Shi S, Zhong Y, Majumdar I, Sri Krishna S, Grishin NV. Bioinformatics June 2007 23(11) 1331-1338

COMPASS server for remote homology inference

Sadreyev RI, Tang M, Kim BH, Grishin NV. Nucleic Acids Res May 2007 35(Web Server issue) W653

MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information.

Pei J, Grishin NV. Nucleic Acids Res August 2006 34(16) 4364-4374

Structural classification of small, disulfide-rich protein domains.

Cheek S, Krishna SS, Grishin NV. J Mol Biol. May 2006 359(1) 215-237

• Finn World Travel Award
  to attend 12th Symposium of the Protein Society (1998)
• UT Southwestern Graduate School
  Nominata Award (1998)
• Department of Pharmacology
  A.G. Gilman award for excellence in research (1997)
• GSO Travel Award
  to attend XVII Congress of Intl. Union of Crystallography (1996)