Research Interest
  • Cholesterol Metabolism
  • Membrane Protein Structural Biology

Publications

Featured Publications LegendFeatured Publications

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL Proc. Natl. Acad. Sci. U.S.A. 2016 Dec
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection.
Lu F, Liang Q, Abi-Mosleh L, Das A, De Brabander JK, Goldstein JL, Brown MS Elife 2015 Dec 4
Structure and mechanism of the uracil transporter UraA.
Lu F, Li S, Jiang Y, Jiang J, Fan H, Lu G, Deng D, Dang S, Zhang X, Wang J, Yan N Nature 2011 Apr 472 7342 243-6
Structure of a fucose transporter in an outward-open conformation.
Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N Nature 2010 Oct 467 7316 734-8
Mechanism of substrate recognition and transport by an amino acid antiporter.
Gao X, Zhou L, Jiao X, Lu F, Yan C, Zeng X, Wang J, Shi Y Nature 2010 Feb 463 7282 828-32
Structure and mechanism of an amino acid antiporter.
Gao X, Lu F, Zhou L, Dang S, Sun L, Li X, Wang J, Shi Y Science 2009 Jun 324 5934 1565-8

Professional Associations/Affiliations
  • American Society for Biochemistry and Molecular Biology (2017)
  • Sigma Xi (2017)