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Michalis Agathokleous, Ph.D.

Michalis Agathokleous, Ph.D.

Titles and Appointments

Assistant Professor

School
Medical School
Department
Children's Medical Center Research Institute at UT Southwestern | Pediatrics
Graduate Programs
Cancer Biology, Genetics, Development and Disease
  • Biography

    Michalis Agathocleous earned his B.A. and Ph.D. degrees at the University of Cambridge, where he studied embryonic retinal development with Dr. Bill Harris. He was a Research Fellow at Gonville and Caius College, University of Cambridge, where he worked on the metabolism of embryonic retinal stem and progenitor cells. He was then an 1851 Research Fellow with Dr. Sean Morrison in Children’s Medical Center Research Institute at UT Southwestern (CRI), where he worked on the metabolism of hematopoietic stem cells and leukemia cells.

    He joined CRI as an Assistant Professor in 2017. Dr. Agathocleous is a Cancer Prevention and Research Institute of Texas Scholar (2017), a recipient of the Alex's Lemonade Stand Foundation 'A' Award (2018), and an American Society of Hematology Scholar (2020).

    The Agathocleous laboratory studies the relationship between metabolism and cell type. They focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny, including cells of the myeloid and T cell lineages. To assess cell type specific metabolism, they have developed techniques to measure metabolites in stem cells and other rare cells isolated from tissues. They aim to understand how metabolism affects hematopoiesis, leukemia development, and the host's response to infection.