Michalis Agathocleous earned his B.A. and Ph.D. degrees at the University of Cambridge, where he studied embryonic retinal development with Dr. Bill Harris. He was a Research Fellow at Gonville and Caius College, University of Cambridge, where he worked on the metabolism of embryonic retinal stem and progenitor cells. He was then an 1851 Research Fellow with Dr. Sean Morrison in Children’s Medical Center Research Institute at UT Southwestern (CRI), where he worked on the metabolism of hematopoietic stem cells and leukemia cells.

He joined CRI as an Assistant Professor in 2017. Dr. Agathocleous is a Cancer Prevention and Research Institute of Texas Scholar (2017), a recipient of the Alex's Lemonade Stand Foundation 'A' Award (2018), and an American Society of Hematology Scholar (2020).

The Agathocleous laboratory studies the relationship between metabolism and cell type. They focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny, including cells of the myeloid and T cell lineages. To assess cell type specific metabolism, they have developed techniques to measure metabolites in stem cells and other rare cells isolated from tissues. They aim to understand how metabolism affects hematopoiesis, leukemia development, and the host's response to infection.



University of Cambridge (2003), Medical Sciences
Graduate School
University of Cambridge (2007), Neuroscience

Research Interest

  • Metabolism of hematopoietic stem cells and leukemia cells
  • The role of stem cells in infection


Featured Publications LegendFeatured Publications

Schistosome Infection Impacts Hematopoiesis.
Wijshake T, Rose J, Wang J, Zielke J, Marlar-Pavey M, Chen W, Collins JJ, Agathocleous M, J Immunol 2024 Jan
Maternal vitamin C regulates reprogramming of DNA methylation and germline development.
DiTroia SP, Percharde M, Guerquin MJ, Wall E, Collignon E, Ebata KT, Mesh K, Mahesula S, Agathocleous M, Laird DJ, Livera G, Ramalho-Santos M, Nature 2019 09 573 7773 271-275
Metabolic regulation of stem cell function.
Burgess RJ, Agathocleous M, Morrison SJ J. Intern. Med. 2014 Apr
Metabolism in physiological cell proliferation and differentiation.
Agathocleous M, Harris WA Trends Cell Biol. 2013 Oct 23 10 484-92

Honors & Awards

  • ASH Faculty Scholar
  • Alex's Lemonade Stand A Award
  • CPRIT Scholar in Cancer Research
  • Gonville and Caius College Cambridge Research Fellowship (2007)
  • Royal Commission for the Exhibition of 1851 Research Fellow (2011)

Professional Associations/Affiliations

  • American Association for Cancer Research (2017)
  • International Society for Stem Cell Research (2014)