Dr. Liu is an Associate Professor in the Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology and Department of Biophysics. He is W.W. Caruth, Jr. Scholar in Biomedical Research of the UT Southwestern Medical Center and a member of the Harold C. Simmons Comprehensive Cancer Center.

Dr. Liu did his graduate research with Dr. Ronen Marmorstein at the Wistar Institute and University of Pennsylvania, where he received his Ph.D. in Chemistry in 2007. Dr. Liu was a Jane Coffin Childs postdoctoral fellow with Dr. Roger Kornberg at Stanford University from 2008 to 2011. Dr. Liu joined the faculty of UT Southwestern in 2011.

Dr. Liu studies the molecular and biophysical mechanisms of chromatin, epigenetics and transcription in development and disease. A current focus is to understand how the developmentally regulated heterochromatin is established, maintained and inherited. To achieve this goal, the Liu lab uses various research tools, such as biochemical reconstitution, X-ray crystallography, cryo-electron microscopy, proteomics and genomics by next-generation sequencing, to study large assemblies of relevant protein-protein and protein-nucleic acid chromatin complexes.


Nanjing University - China (2000), Biochemistry
Graduate School
University of Pennsylvania (2007), Chemistry

Research Interest

  • Chromatin and Epigenetics
  • Chromatin Dysregulation in Disease
  • Non-coding RNAs
  • Structural Biology


Featured Publications LegendFeatured Publications

Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance.
Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J, Cancer Discov 2022 Oct
PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function.
Liu X, Liu X, Front Oncol 2022 12 894585
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
Park SH, Fong KW, Kim J, Wang F, Lu X, Lee Y, Brea LT, Wadosky K, Guo C, Abdulkadir SA, Crispino JD, Fang D, Ntziachristos P, Liu X, Li X, Wan Y, Goodrich DW, Zhao JC, Yu J, Sci Adv 2021 Apr 7 15

Honors & Awards

  • Rita Allen Scholar
    Rita Allen Foundation (2012)
  • CPRIT Scholar in Cancer Research
    Cancer Prevention Research Institute of Texas (2011)
  • W.W. Caruth, Jr. Scholar in Biomedical Research
    UT Southwestern Medical Center (2011)
  • Jane Coffin Childs Postdoctoral Fellowship
    The Jane Coffin Childs Memorial Fund for Medical Research (2008)
  • Dr. Monica H.M. Shander Award
    The Wistar Institute (2006)