Joel Goodman was born in New York City but grew up in Los Angeles. He received a B.A. from UC San Diego in 1971 with a major in biology and minor in music. Before entering graduate school he worked as a research technician at Childrens Hospital in Los Angeles and also pursued his interest as a classical pianist, giving several recitals in the Los Angeles area. In 1975 Dr. Goodman began his doctoral studies in Pharmacology in the laboratory of Paul Hochstein. The interest of the laboratory was oxygen metabolism, and Dr. Goodman’s dissertation developed his observation in the laboratory that the anthracycline cancer drugs undergo redox cycling causing tissue toxicity. After graduating in 1980, he performed his postdoctoral training in William Wicker’s laboratory at UCLA, where he studied protein translocation across membranes. Dr. Goodman’s contributions include cloning the bacterial leader peptidase and establishing an in vitro system to study translocation of a model viral protein.
In 1982 Dr. Goodman joined the pharmacology faculty of UT Southwestern, where he has remained ever since. For the next two decades he studied the assembly of peroxisomes, using yeast as a model system. His contributions include the identification of the first peroxisomal membrane sorting signal, the first peroxisomal fission factor, and the oligomeric import pathway. In more recent years he has studied lipid droplet assembly, particularly the role of lipodystrophy proteins in this process.
Outside of UT Southwestern, Dr. Goodman has maintained his interest in classical piano. In the past several years he has performed in piano competitions in the US and abroad and was featured as soloist with the Fort Worth Symphony in 2010 and 2014.
- University of California-San D (1971)
- Graduate School
- University of California-Los A (1980), Molecular Biology
- Lipid droplets
- Membrane structure
- Protein trafficking
- Yeast cell biology
- The gregarious lipid droplet
- J. M. Goodman J. Biol. Chem. October 2008 283 28005-9
- An intimate collaboration between peroxisomes and lipid bodies
- Binns, D.D., Januszewski, T.C., Chen, Y., Hill, J.J., Markin, V.S., Zhao, Y., Gilpin, C.J., Chapman, K.D., Anderson, R.G.W., and Goodman, J.M. J. Cell Biol. June 2006 173 719-731
- Multiple targeting modules on peroxisomal proteins are not redundant: discrete functions of targeting signals within Pmp47 and Pex8p.
- Wang X, McMahon MA, Shelton SN, Nampaisansuk M, Ballard JL, Goodman JM Mol. Biol. Cell 2004 Apr 15 4 1702-10
- Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase.
- Shelton SN, Barylko B, Binns DD, Horazdovsky BF, Albanesi JP, Goodman JM Biochem. J. 2003 Apr 371 Pt 2 533-40
- The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a hydrophilic loop
- Dyer, J.M., McNew, J.A. and Goodman, J.M. J. Cell Biol. 1996 133 269-280
- Redox-sensitive homodimerization of peroxisomal Pmp27: A proposed mechanism to regulate organellar division
- Marshall, P.A., Dyer, J.M., Quick, M.E., and Goodman, J.M. J. Cell Biol. 1996 135 123-137
- An oligomeric protein is imported into peroxisomes in vivo
- McNew, J.M., Goodman, J.M. J. Cell Biol. 1994 127 1245-1257
Honors & Awards
- Minnie Stevens Piper Professorship
- University of Texas Regents' Outstanding Teaching Award
- Distinguished Basic Science Educator Award
- John P. Perkins Distinguished Professorship in Biomedical Science
- University of Texas Academy of Health Science Education
- Southwestern Academy of Teachers
- Jan and Bob Bullock Distinguished Chair for Science Education
- Outstanding Teacher Award
Medical School sophomore class, various years (1987-2007)
- American Society for Biochemistry and Molecular Biology
- American Society for Cell Biology
- American Society for Microbiology
- American Society for Pharmacology and Experimental Therapeutics
- Sigma XI