Education

Undergraduate
Fudan University (2001), Chemistry
Graduate School
Univ of California-Berkeley (2006), Chemistry

Research Interest

  • Mass Spectrometry
  • Post-translational Modifications (e.g. Phosphorylation and ADP-ribosylation)
  • Quantitative Proteomics
  • Signal Transduction/Cancer Biology and Metabolism

Publications

Featured Publications LegendFeatured Publications

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.
Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, Chen J, Lin SH, Nat Commun 2019 Sep 10 1 4363
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.
Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY, Ji Y, Li C, Guo L, Zhou L, Chen Z, Leon-Mimila P, Chung MT, Kurabayashi K, Opp J, Campos-Pérez F, Villamil-Ramírez H, Canizales-Quinteros S, Lyons R, Lumeng CN, Zhou B, Qi L, Huertas-Vazquez A, Lusis AJ, Xu XZS, Li S, Yu Y, Li JZ, Lin JD, Mol. Cell 2019 Aug 75 3 644-660.e5
Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink.
Ye C, Sutter BM, Wang Y, Kuang Z, Zhao X, Yu Y, Tu BP Mol. Cell 2019 Feb
Site-specific analysis of the Asp- and Glu-ADP-ribosylated proteome by quantitative mass spectrometry.
Li P, Zhen Y, Yu Y, Meth. Enzymol. 2019 626 301-321
Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi.
Xiong X, Wang Q, Wang S, Zhang J, Liu T, Guo L, Yu Y, Lin JD Mol Metab 2018 Dec
Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.
Wang Z, Ma J, Miyoshi C, Li Y, Sato M, Ogawa Y, Lou T, Ma C, Gao X, Lee C, Fujiyama T, Yang X, Zhou S, Hotta-Hirashima N, Klewe-Nebenius D, Ikkyu A, Kakizaki M, Kanno S, Cao L, Takahashi S, Peng J, Yu Y, Funato H, Yanagisawa M, Liu Q Nature 2018 Jun
Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle.
Dutchak PA, Estill-Terpack SJ, Plec AA, Zhao X, Yang C, Chen J, Ko B, Deberardinis RJ, Yu Y, Tu BP Cell Rep 2018 May 23 7 1907-1914
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
He L, Gomes AP, Wang X, Yoon SO, Lee G, Nagiec MJ, Cho S, Chavez A, Islam T, Yu Y, Asara JM, Kim BY, Blenis J Mol. Cell 2018 May
Proteomic analysis of the downstream signaling network of PARP1.
Zhen Y, Yu Y Biochemistry 2018 Jan

Honors & Awards

  • Special issue of “Future of Biochemistry”
    Biochemistry (2018)
  • Developmental Research Program Award
    NCI Lung Cancer SPORE (Specialized Programs of Research Excellence) (2017)
  • Young Investigator Award
    Chinese American Diabetes Association (2017)
  • ACS Research Scholar
    American Cancer Society (2015)
  • CPRIT Scholar in Cancer Research
    Cancer Prevention Research Institute of Texas (2011)
  • University of Texas STARS award
    University of Texas System (2011)
  • Virginia Murchison Linthicum Scholar in Medical Research
    UT Southwestern Medical Center (2011)
  • Tuberous Sclerosis Alliance Postdoctoral Fellowship
    Tuberous Sclerosis Alliance (2008)
  • Chun-Tsung Scholar
    Chun-Tsung Endowment (1999)

Professional Associations/Affiliations

  • American Association for Cancer Research (2013)
  • American Society for Mass Spectrometry (2001)