Dr. Yu received his undergraduate degree in chemistry from Fudan University in 2001. He received his Ph.D. in Chemistry from the University of California, Berkeley in 2006 under the direction of Julie Leary, where he developed mass spectrometric approaches for the study of protein-ligand interactions. As a graduate student, he also developed a series of proteomic technologies for the study of tyrosine sulfation, a protein post-translational modification that is implicated in regulating protein-protein interactions in the extracellular space.
In 2007, Dr. Yu joined the laboratories of Steven Gygi and John Blenis in the Department of Cell Biology at Harvard Medical School for his post-doctoral training (in both quantitative proteomics and signal transduction). There he developed quantitative mass spectrometric strategies for the study of protein phosphorylation. He deployed these powerful technologies to characterize the PI3K/Akt/mTORC1 pathway, and identified their downstream signaling modules that control a variety of cellular anabolic processes.
In 2012, Dr. Yu began his independent research career as an Assistant Professor in the Department of Biochemistry at UT Southwestern Medical Center. He was promoted to Associate Professor with tenure in 2017. Throughout his career, Dr. Yu has been the recipient of numerous awards for his research, including the Tuberous Sclerosis Alliance Postdoctoral Fellowship, a CPRIT Scholar in Cancer Research award, a Virginia Murchison Linthicum Scholar in Medical Research award, a Research Scholar award from the American Cancer Society, a UT System Rising STARs Award and most recently, an R35 MIRA award from NIGMS. He has served on many NIH and DoD advisory panels, including as a current member of the NIH Enabling Bioanalytical and Imaging Technologies (EBIT) Study Section.
The long-term goals of the Yu lab are to develop cutting-edge, mass spectrometry-based proteomic technologies, and applying them to systematically identify novel protein modifications and the related "dark matter" within in the human proteome. These data-driven strategies are then combined with classical biochemistry approaches to chacterize aberrant protein modification patterns, decipher the mechanisms of their deregulation, establish the functional consequences of these molecular events, facilitate the development of relevant therapeutic strategies, and finally, identify proteomic signatures that may serve as diagnostic, prognostic or predictive biomarkers for the relevant diseases (e.g., cancer, diabetes and neurodegenerative disease).
- Fudan University (2001), Chemistry
- Graduate School
- Univ of California-Berkeley (2006), Chemistry
- Mass Spectrometry
- Post-translational Modifications (e.g. Phosphorylation and ADP-ribosylation)
- Quantitative Proteomics
- Signal Transduction/Cancer Biology and Metabolism
- Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation.
- Wang S, Han L, Han J, Li P, Ding Q, Zhang QJ, Liu ZP, Chen C, Yu Y, Nat. Chem. Biol. 2019 Oct
- Subtype-specific secretomic characterization of pulmonary neuroendocrine tumor cells.
- Wang XD, Hu R, Ding Q, Savage TK, Huffman KE, Williams N, Cobb MH, Minna JD, Johnson JE, Yu Y, Nat Commun 2019 Jul 10 1 3201
- A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer.
- Zhen Y, Zhang Y, Yu Y Cell Rep 2017 Nov 21 8 2326-2337
- Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes.
- Zhang Y, Zhang Y, Yu Y J. Proteome Res. 2017 Jul
- Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.
- Gibson BA, Zhang Y, Jiang H, Hussey KM, Shrimp JH, Lin H, Schwede F, Yu Y, Kraus WL Science 2016 Jun
- Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling.
- Ding M, Bruick RK, Yu Y Nat. Cell Biol. 2016 Feb
- The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei.
- Xiang S, Kato M, Wu LC, Lin Y, Ding M, Zhang Y, Yu Y, McKnight SL Cell 2015 Nov 163 4 829-39
- Crescendo: A Protein Sequence Database Search Engine for Tandem Mass Spectra.
- Wang J, Zhang Y, Yu Y J. Am. Soc. Mass Spectrom. 2015 Apr
- Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome.
- Zhang Y, Wang J, Ding M, Yu Y Nat. Methods 2013 Aug
- Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
- Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J Science 2011 Jun 332 6035 1322-6
Honors & Awards
- R35 MIRA award
- Special issue of Future of Biochemistry
- Developmental Research Program Award
NCI Lung Cancer SPORE (Specialized Programs of Research Excellence) (2017)
- Young Investigator Award
Chinese American Diabetes Association (2017)
- ACS Research Scholar
American Cancer Society (2015)
- CPRIT Scholar in Cancer Research
Cancer Prevention Research Institute of Texas (2011)
- University of Texas STARS award
University of Texas System (2011)
- Virginia Murchison Linthicum Scholar in Medical Research
UT Southwestern Medical Center (2011)
- Tuberous Sclerosis Alliance Postdoctoral Fellowship
Tuberous Sclerosis Alliance (2008)
- Chun-Tsung Scholar
Chun-Tsung Endowment (1999)
- American Association for Cancer Research (2013)
- American Society for Mass Spectrometry (2001)