Robert E. Lenkinski, Ph.D., is Professor of Radiology and Vice Chair of Radiology Research at UT Southwestern. He holds the Charles A. and Elizabeth Ann Sanders Chair in Translational Research, and the Jan and Bob Pickens Distinguished Professorship in Medical Science, in Memory of Jerry Knight Rymer and Annette Brannon Rymer and Mr. and Mrs. W.L. Pickens.
Born in a refugee camp in Germany in 1947, Dr. Lenkinski emigrated with his parents to Toronto, Canada, in 1950. He holds a bachelor’s degree in chemistry from the University of Toronto, and earned his doctorate in chemistry from the University of Houston. He then received advanced training at the Weizmann Institute of Science in Israel through a postdoctoral fellowship program in isotope research.
Before joining the faculty at UT Southwestern in 2011, Dr. Lenkinski served as Professor of Radiology at Harvard Medical School. Earlier academic appointments include Visiting Assistant Professor of Chemistry at the University of Houston, Research Assistant Professor of Physiology and Biophysics at the University of Illinois College of Medicine in Chicago, Assistant Professor of Biochemistry at the University of Alabama in Birmingham, Visiting Assistant Professor of Chemistry at the Weizmann Institute of Science, Associate Professor of Chemistry at the University of Guelph in Canada, and Associate Professor of Radiological Science at the University of Pennsylvania School of Medicine, where he received his first appointment as Professor.
An array of research interests
A major focus of Dr. Lenkinski’s research involves developing, validating and applying magnetic resonance spectroscopic (MRS) and multinuclear imaging methods for the study of human disease. He wants to understand how the metabolic information derived from these methods can aid in the diagnosis, staging and treatment of a variety of pathologies. Current applications involve brain tumors, breast cancer, prostate cancer and renal function.
Dr. Lenkinski is also investigating targeted molecular imaging agents, including lanthanide based MRI relaxation and shift reagents and their conjugation to low-molecular weight ligands and their analogous PET tracers. He wants to develop targeted agents for imaging of micro-calcifications in human breast cancer.
Additional research involves the development and validation of a number of quantitative MRI methods, including arterial spin labeling, dynamic contrast enhanced MRI, and diffusion weighted MRI, for the study of human disease.
A career characterized by innovation
As one of the four co-inventors of the endorectal coil for MR imaging of prostate disease, Dr. Lenkinski has seen it become the standard of care in prostate MR throughout the world. Other career accomplishments include building a multicoil array for MR imaging of breast cancer to improve the diagnostic accuracy of lesion characterization; implementing dynamic contrast enhanced MRI of the prostate to improve staging and detection of prostate cancer; demonstrating the potential for correlating genetic expression profiles with phenotypes of human prostate cancer; developing multimodality, targeted contrast agents for imaging malignant micro-calcifications in human breast cancer; establishing an interdisciplinary carbon-13 hyper-polarization NMR program for “pathway specific” metabolic imaging in oncology; launching an MRI program to characterize suspicious lung nodules; and initiating a multimodality (PET/MRI) preclinical imaging program.
Dr. Lenkinski is an active member of multiple professional societies, including the International Society of Magnetic Resonance in Medicine, Radiological Society of North America, American Association for the Advancement of Science, and Alpha Chi Sigma.
In addition to more than 210 original research articles, Dr. Lenkinski has contributed to 15 textbooks and serves as an editor for Academic Radiology and the Journal of Magnetic Resonance Imaging, and as a reviewer for Radiology and Magnetic Resonance in Medicine.
Dr. Lenkinski enjoys playing golf, reading, listening to classical and contemporary music, and spending time with his family.
- University of Toronto - Canada (1968), Chemistry
- Graduate School
- University of Houston-System A (1973), Chemistry
- Related Publications by Dr. Lenkinski
- Clinical applications of in vivo magnetic resonance imaging and spectroscopy
- In vivo multinuclear MR imaging methods, primarily Na-23
- Novel MR and optical based imaging contrast agents in molecular imaging
- Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results.
- Bloch BN, Furman-Haran E, Helbich TH, Lenkinski RE, Degani H, Kratzik C, Susani M, Haitel A, Jaromi S, Ngo L, Rofsky NM Radiology 2007 Oct 245 1 176-85
- A systematic literature review of magnetic resonance spectroscopy for the characterization of brain tumors.
- Hollingworth W, Medina LS, Lenkinski RE, Shibata DK, Bernal B, Zurakowski D, Comstock B, Jarvik JG AJNR Am J Neuroradiol 2006 Aug 27 7 1404-11
- A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age.
- Chang L, Lee PL, Yiannoutsos CT, Ernst T, Marra CM, Richards T, Kolson D, Schifitto G, Jarvik JG, Miller EN, Lenkinski R, Gonzalez G, Navia BA Neuroimage 2004 Dec 23 4 1336-47
- Radiofrequency ablation: effect of surrounding tissue composition on coagulation necrosis in a canine tumor model.
- Ahmed M, Liu Z, Afzal KS, Weeks D, Lobo SM, Kruskal JB, Lenkinski RE, Goldberg SN Radiology 2004 Mar 230 3 761-7
- PARACEST agents: modulating MRI contrast via water proton exchange.
- Zhang S, Merritt M, Woessner DE, Lenkinski RE, Sherry AD Acc. Chem. Res. 2003 Oct 36 10 783-90
- Transient central nervous system white matter abnormality in X-linked Charcot-Marie-Tooth disease.
- Paulson HL, Garbern JY, Hoban TF, Krajewski KM, Lewis RA, Fischbeck KH, Grossman RI, Lenkinski R, Kamholz JA, Shy ME Ann. Neurol. 2002 Oct 52 4 429-34
- Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions.
- Katz-Brull R, Lavin PT, Lenkinski RE J. Natl. Cancer Inst. 2002 Aug 94 16 1197-203
- In vivo near-infrared fluorescence imaging of osteoblastic activity.
- Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV Nat. Biotechnol. 2001 Dec 19 12 1148-54
- The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy.
- Cecil KM, Schnall MD, Siegelman ES, Lenkinski RE Breast Cancer Res. Treat. 2001 Jul 68 1 45-54
- Radio-frequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study.
- Goldberg SN, Ahmed M, Gazelle GS, Kruskal JB, Huertas JC, Halpern EF, Oliver BS, Lenkinski RE Radiology 2001 Apr 219 1 157-65
Honors & Awards
- CPRIT Cancer Scholar in Residence
Missing Link Award (2011)
- Luigi Mastroianni Clinical Innovator Award, School of Medicine, University of Pennsylvania
Award for the construction of the endo-rectal MR coil for prostate imaging (1999)
International Society of Magnetic Resonance in Medicine (1997)
- Member Sigma Xi
Honorary Scientific Organization (1971)
- Alpha Chi Sigma
- American Association for the Advancement of Science
- International Society of Magnetic Resonance in Medicine
- Radiological Society of North America