Dr. Malter joined the UTSW faculty as Professor and Chairman of the Department of Pathology in August, 2011. He holds the Senator Betty and Dr. Andy Andujar Distinguished Chair in Pathology. A graduate of Dartmouth College and Washington University School of Medicine in St. Louis, he completed a post-doc and residency training in pathology and laboratory medicine at the University of Pennsylvania. In 1991, he joined the Department of Pathology and Laboratory Medicine at the University of Wisconsin School of Medicine and Public Health. He was Medical Director of the Blood Bank and Transfusion Service (1991-2011) and Molecular Diagnostics Laboratory (2002-2008) for UW Hospital and served as Acting Chair of the Department of Pathology (1993-95). In 2002, Dr. Malter was named an Investigator at the Waisman Center for Developmental Disabilities, UW-Graduate School and became the Cell and Molecular Neuroscience Core Director in 2003 and Associate Director for Biological Sciences in 2004. His research has been continuously funded by the National Institutes of Health and other agencies since 1988 and is currently supported by multiple individual as well as program project grants for his scientific work in post-transcriptional gene regulation and signaling in the immune and nervous systems. He is a member of both the American Society for Investigative Pathology and the American Society for Clinical Investigation, past Chair of several NIH review panels and current member of the editorial boards of Science Signaling.
- Medical School
- Washington University School of Medicine (1983)
- University of Pennsylvania School of Medicine (1988), Pathology/lab Medicine
- The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils.
- Shen ZJ, Esnault S, Malter JS Nat. Immunol. 2005 Dec 6 12
- The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95.
- Todd PK, Mack KJ, Malter JS Proc. Natl. Acad. Sci. U.S.A. 2003 Nov 100 24
- Nucleolin and heterogeneous nuclear ribonucleoprotein C proteins specifically interact with the 3'-untranslated region of amyloid protein precursor mRNA.
- Zaidi SH, Malter JS J. Biol. Chem. 1995 Jul 270 29
- Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region.
- Zaidi SH, Malter JS J. Biol. Chem. 1994 Sep 269 39
- Multiple proteins interact at a unique cis-element in the 3'-untranslated region of amyloid precursor protein mRNA.
- Zaidi SH, Denman R, Malter JS J. Biol. Chem. 1994 Sep 269 39
- Tumor necrosis factor alpha-induced glucose transporter (GLUT-1) mRNA stabilization in 3T3-L1 preadipocytes. Regulation by the adenosine-uridine binding factor.
- Stephens JM, Carter BZ, Pekala PH, Malter JS J. Biol. Chem. 1992 Apr 267 12
- Identification of an AUUUA-specific messenger RNA binding protein.
- Malter JS Science 1989 Nov 246 4930
- Pin1 regulates axonal growth cone adhesion and spreading through MARCKS isomerization.
- Sosa LJ, Malter JS, Hu J, Bustos Plonka F, Oksdath M, Nieto Guil A, Quiroga S, Pfenninger KH J. Neurochem. 2016 Mar
- Phosphate-Induced Renal Fibrosis Requires the Prolyl Isomerase Pin1.
- Shen ZJ, Hu J, Shiizaki K, Kuro-O M, Malter JS PLoS ONE 2016 11 2 e0150093
- The DNA Sensor AIM2 Maintains Intestinal Homeostasis via Regulation of Epithelial Antimicrobial Host Defense.
- Hu S, Peng L, Kwak YT, Tekippe EM, Pasare C, Malter JS, Hooper LV, Zaki MH Cell Rep 2015 Dec 13 9 1922-36
Honors & Awards
American Society for Clinical Investigation (1998)
Romnes Fellow, University of Wisconsin, Madison, WI (1993)
- Outstanding Young Investigator
Academy of Clinical Laboratory Physicians & Scientists (1987)
National Research Service Award (1986)
- Rufus Choate Scholar
Biochemistry - Dartmouth College (1978)
- American Association for the Advancement of Science
- American Association of Blood Banks
- American Society for Clinical Investigation
- American Society for Investigative Pathology
- American Society of Biochemistry and Molecular Biology