James Malter, M.D.

Professor & Chair

Endowed Title: The Senator Betty and Dr. Andy Andujar Distinguished Chairmanship of Pathology
School: Medical School
Department: Pathology
Graduate Programs: Cell and Molecular Biology, Immunology

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Biography

Dr. Malter joined the UTSW faculty as Professor and Chairman of the Department of Pathology in August, 2011. He holds the Senator Betty and Dr. Andy Andujar Distinguished Chair in Pathology. A graduate of Dartmouth College and Washington University School of Medicine in St. Louis, he completed a post-doc and residency training in pathology and laboratory medicine at the University of Pennsylvania. In 1991, he joined the Department of Pathology and Laboratory Medicine at the University of Wisconsin School of Medicine and Public Health. He was Medical Director of the Blood Bank and Transfusion Service (1991-2011) and Molecular Diagnostics Laboratory (2002-2008) for UW Hospital and served as Acting Chair of the Department of Pathology (1993-95). In 2002, Dr. Malter was named an Investigator at the Waisman Center for Developmental Disabilities, UW-Graduate School and became the Cell and Molecular Neuroscience Core Director in 2003 and Associate Director for Biological Sciences in 2004. His research has been continuously funded by the National Institutes of Health and other agencies since 1988 and is currently supported by multiple individual as well as program project grants for his scientific work in post-transcriptional gene regulation and signaling in the immune and nervous systems. He is a member of both the American Society for Investigative Pathology and the American Society for Clinical Investigation, past Chair of several NIH review panels and current member of the editorial boards of Science Signaling.

Education

Medical School: Washington University School of Medicine (1983)
Residency: University of Pennsylvania School of Medicine (1988), Pathology/lab Medicine

Publications

Featured Publications

Alzheimer's Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?: O'Neal MA, Stallings NR, Malter JS ACS Chem Neurosci 2018 May
-induced dendritic spine loss.: Stallings NR, O'Neal MA, Hu J, Kavalali ET, Bezprozvanny I, Malter JS Sci Signal 2018 Mar 11 522
XBP1, a determinant of the eosinophil lineage.: Shen ZJ, Malter JS Nat. Immunol. 2015 Jul 16 8 793-4
Pin1-FADD Interactions Regulate Fas-Mediated Apoptosis in Activated Eosinophils.: Oh J, Malter JS J. Immunol. 2013 Apr
Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.: Shen ZJ, Braun RK, Hu J, Xie Q, Chu H, Love RB, Stodola LA, Rosenthal LA, Szakaly RJ, Sorkness RL, Malter JS J. Biol. Chem. 2012 Jul 287 28 23294-305
Reversal of fragile X phenotypes by manipulation of A?PP/A? levels in Fmr1KO mice.: Westmark CJ, Westmark PR, O'Riordan KJ, Ray BC, Hervey CM, Salamat MS, Abozeid SH, Stein KM, Stodola LA, Tranfaglia M, Burger C, Berry-Kravis EM, Malter JS PLoS ONE 2011 6 10 e26549
Pin1 and PKMzeta sequentially control dendritic protein synthesis.: Westmark PR, Westmark CJ, Wang S, Levenson J, O'Riordan KJ, Burger C, Malter JS Sci Signal 2010 3 112
The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation.: Shen ZJ, Esnault S, Schinzel A, Borner C, Malter JS Nat. Immunol. 2009 Mar 10 3
Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis.: Shen ZJ, Esnault S, Rosenthal LA, Szakaly RJ, Sorkness RL, Westmark PR, Sandor M, Malter JS J. Clin. Invest. 2008 Feb 118 2
FMRP mediates mGluR5-dependent translation of amyloid precursor protein.: Westmark CJ, Malter JS PLoS Biol. 2007 Mar 5 3

Honors & Awards

Member
American Society for Clinical Investigation (1998)
Nominee
Romnes Fellow, University of Wisconsin, Madison, WI (1993)
Outstanding Young Investigator
Academy of Clinical Laboratory Physicians & Scientists (1987)
NIH
National Research Service Award (1986)
Rufus Choate Scholar
Biochemistry - Dartmouth College (1978)

Professional Associations/Affiliations

American Association for the Advancement of Science
American Association of Blood Banks
American Society for Clinical Investigation
American Society for Investigative Pathology
American Society of Biochemistry and Molecular Biology