The O’Donnell laboratory is focused on understanding the mechanisms that contribute to tumor initiation, progression, and metastasis. Our lab has made significant contributions to the development and utilization of in vivo and ex vivo transposon mutagenesis systems. We have identified novel genes that promote liver cancer, leukemia, and non-small cell lung cancer.

Currently, we are investigating the regulation and function of cell-surface receptors in lung cancer using molecular and biochemical studies and animal models. These studies may provide new therapeutic approaches to target cancer cells.


Cornell University (1998), Biology
Graduate School
Johns Hopkins University (2005), Genetics

Research Interest

  • Cancer
  • CRISPR Genome Editing
  • Mechanisms of lung cancer pathogenesis
  • Mouse models of cancer


Featured Publications LegendFeatured Publications

Honors & Awards

  • Friends of the Comprehensive Cancer Center Award in Cancer Research
  • LUNGevity Foundation Career Development Award
  • Sidney Kimmel Scholar Award
  • American Cancer Society - Simmons Cancer Center New Investigator Award
  • CPRIT Scholar in Cancer Research
  • Damon Runyon Foundation Postdoctoral Fellowship Award
  • AACR Scholar-in-Training Award
  • AACR Scholar-in-Training Award

Professional Associations/Affiliations

  • Center for Regenerative Science and Medicine (2017)
  • Cancer Biology Graduate Program (2011)
  • Genetics and Development Graduate Program (2011)
  • Harold C. Simmons Comprehensive Cancer Center (2011)
  • American Association for Cancer Research (2001)