Joshua Mendell, M.D., Ph.D.

Professor

Endowed Title: Charles Cameron Sprague, M.D., Chair in Medical Science
School: Medical School
Department: Molecular Biology
Graduate Programs: Cancer Biology, Genetics, Development and Disease

Education

Undergraduate: Cornell University (1996), Biology
Medical School: Johns Hopkins University (2004), Medicine
Graduate School: Johns Hopkins University (2004), Molecular Biology

Research Interest

Cancer
MicroRNAs
Noncoding RNAs
Post-transcriptional Regulation

Publications

Featured Publications

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes.: Zhu X, Cruz VE, Zhang H, Erzberger JP, Mendell JT, Science 2024 Nov 386 6724 eadq8587
A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence.: Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT, Cell 2024 Jun
NORAD-induced Pumilio phase separation is required for genome stability.: Elguindy MM, Mendell JT, Nature 2021 Jun
A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming: Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT Science 2020 370 6523 eabc9546
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.: Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT Nature 2017 Jan
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.: Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT Cell 2016 Jan 164 1-2 69-80
An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration.: Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC, Yopp AC, Maitra A, Mendell JT Cell 2014 May 157 5 1104-16
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.: Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT Cell 2009 Jun 137 6 1005-17
c-Myc-regulated microRNAs modulate E2F1 expression.: O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT Nature 2005 Jun 435 7043 839-43
An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation.: Lee JS, Dan T, Zhang H, Cheng Y, Rehfeld F, Brugarolas J, Mendell JT, Mol Cell 2025 Apr 85 8 1543-1560.e10

Honors & Awards

American Society for Clinical Investigation (ASCI)
(2020)
Paul Marks Prize for Cancer Research
(2019)
Edith and Peter O'Donnell Award, Texas Academy of Medicine, Engineering, Science, and Technology (TAMEST)
(2016)
Investigator, Howard Hughes Medical Institute
(2015)
CPRIT Scholar in Cancer Research
(2011)
AACR Outstanding Achievement in Cancer Research Award
(2010)
Howard Hughes Medical Institute Early Career Scientist
(2009)
Leukemia and Lymphoma Society Scholar
(2008)
Allan C. Davis Medal
Outstanding Young Scientist in the State of Maryland (2007)
Rita Allen Foundation Scholar
(2006)
March of Dimes Basil OConnor Scholar
(2004)