Joshua Mendell, M.D., Ph.D.

Undergraduate

Cornell University (1996), Biology

Medical School

Johns Hopkins University (2004), Medicine

Graduate School

Johns Hopkins University (2004), Molecular Biology

• Cancer
• MicroRNAs
• Noncoding RNAs
• Post-transcriptional Regulation

Featured Publications

RBM33 directs the nuclear export of transcripts containing GC-rich elements.

Thomas A, Rehfeld F, Zhang H, Chang TC, Goodarzi M, Gillet F, Mendell JT, Genes Dev 2022 May

NORAD-induced Pumilio phase separation is required for genome stability.

Elguindy MM, Mendell JT, Nature 2021 Jun

A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming

Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT Science 2020 370 6523 eabc9546

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

Kopp F, Elguindy MM, Yalvac ME, Zhang H, Chen B, Gillett FA, Lee S, Sivakumar S, Yu H, Xie Y, Mishra P, Sahenk Z, Mendell JT. eLife 2019 8 e42650

Functional Classification and Experimental Dissection of Long Noncoding RNAs.

Kopp F, Mendell JT Cell 2018 Jan 172 3 393-407

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.

Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT Nature 2017 Jan

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.

Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT Cell 2016 Jan 164 1-2 69-80

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration.

Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC, Yopp AC, Maitra A, Mendell JT Cell 2014 May 157 5 1104-16

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.

Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT Cell 2009 Jun 137 6 1005-17

c-Myc-regulated microRNAs modulate E2F1 expression.

O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT Nature 2005 Jun 435 7043 839-43

• American Society for Clinical Investigation (ASCI)
  (2020)
• Paul Marks Prize for Cancer Research
  (2019)
• Edith and Peter O’Donnell Award, Texas Academy of Medicine, Engineering, Science, and Technology (TAMEST)
  (2016)
• Investigator, Howard Hughes Medical Institute
  (2015)
• CPRIT Scholar in Cancer Research
  (2011)
• AACR Outstanding Achievement in Cancer Research Award
  (2010)
• Howard Hughes Medical Institute Early Career Scientist
  (2009)
• Leukemia and Lymphoma Society Scholar
  (2008)
• Allan C. Davis Medal
  Outstanding Young Scientist in the State of Maryland (2007)
• Rita Allen Foundation Scholar
  (2006)
• March of Dimes Basil O’Connor Scholar
  (2004)