
Joshua Mendell, M.D., Ph.D.
Professor
Endowed Title Charles Cameron Sprague, M.D., Chair in Medical Science
Department Molecular Biology
Graduate Programs Cancer Biology, Genetics, Development and Disease
Education
- Undergraduate
- Cornell University (1996), Biology
- Medical School
- Johns Hopkins University (2004), Medicine
- Graduate School
- Johns Hopkins University (2004), Molecular Biology
Research Interest
- Cancer
- MicroRNAs
- Noncoding RNAs
- Post-transcriptional Regulation
Publications
Featured Publications
- RBM33 directs the nuclear export of transcripts containing GC-rich elements.
- Thomas A, Rehfeld F, Zhang H, Chang TC, Goodarzi M, Gillet F, Mendell JT, Genes Dev 2022 May
- NORAD-induced Pumilio phase separation is required for genome stability.
- Elguindy MM, Mendell JT, Nature 2021 Jun
- A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming
- Han J, LaVigne CA, Jones BT, Zhang H, Gillett F, Mendell JT Science 2020 370 6523 eabc9546
- PUMILIO hyperactivity drives premature aging of Norad-deficient mice
- Kopp F, Elguindy MM, Yalvac ME, Zhang H, Chen B, Gillett FA, Lee S, Sivakumar S, Yu H, Xie Y, Mishra P, Sahenk Z, Mendell JT. eLife 2019 8 e42650
- Functional Classification and Experimental Dissection of Long Noncoding RNAs.
- Kopp F, Mendell JT Cell 2018 Jan 172 3 393-407
- An Argonaute phosphorylation cycle promotes microRNA-mediated silencing.
- Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT Nature 2017 Jan
- Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.
- Lee S, Kopp F, Chang TC, Sataluri A, Chen B, Sivakumar S, Yu H, Xie Y, Mendell JT Cell 2016 Jan 164 1-2 69-80
- An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration.
- Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, Abdelnaby AA, Balch GC, Mansour JC, Yopp AC, Maitra A, Mendell JT Cell 2014 May 157 5 1104-16
- Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.
- Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT Cell 2009 Jun 137 6 1005-17
- c-Myc-regulated microRNAs modulate E2F1 expression.
- O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT Nature 2005 Jun 435 7043 839-43
Honors & Awards
- American Society for Clinical Investigation (ASCI)
(2020) - Paul Marks Prize for Cancer Research
(2019) - Edith and Peter ODonnell Award, Texas Academy of Medicine, Engineering, Science, and Technology (TAMEST)
(2016) - Investigator, Howard Hughes Medical Institute
(2015) - CPRIT Scholar in Cancer Research
(2011) - AACR Outstanding Achievement in Cancer Research Award
(2010) - Howard Hughes Medical Institute Early Career Scientist
(2009) - Leukemia and Lymphoma Society Scholar
(2008) - Allan C. Davis Medal
Outstanding Young Scientist in the State of Maryland (2007) - Rita Allen Foundation Scholar
(2006) - March of Dimes Basil OConnor Scholar
(2004)