Graduate School
SUNY Downstate Medical Center (2002)
Medical School
SUNY Downstate Medical Center (2006)
SUNY Downstate Medical Center (2007), Internal Medicine
Montefiore Med. Ctr. & Albert Einstein College of Med. (2011), Radiation Oncology

Research Interest

  • Improve cancer patient treatment outcome through the design of i-SAbR clinical trials
  • Innate and adaptive immune responses generated by tumor irradiation with stereotactic ablative radiotherapy (SAbR)
  • Investigate strategies to combine immunotherapy with SAbR (i-SAbR) for cancer treatment


Featured Publications LegendFeatured Publications

Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity
Zhang F, Manna S, Pop LM, Chen ZJ, Fu YX, Hannan R Semin Radiat Oncol 2020 30 2 129-138
An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors.
Wang T, Lu R, Kapur P, Jaiswal BS, Hannan R, Zhang Z, Pedrosa I, Luke JJ, Zhang H, Goldstein LD, Yousuf Q, Gu YF, McKenzie T, Joyce A, Kim MS, Wang X, Luo D, Onabolu O, Stevens C, Xie Z, Chen M, Filatenkov A, Torrealba J, Luo X, Guo W, He J, Stawiski E, Modrusan Z, Durinck S, Seshagiri S, Brugarolas J Cancer Discov 2018 Jun
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression.
Tang H, Liang Y, Anders RA, Taube JM, Qiu X, Mulgaonkar A, Liu X, Harrington SM, Guo J, Xin Y, Xiong Y, Nham K, Silvers W, Hao G, Sun X, Chen M, Hannan R, Qiao J, Dong H, Peng H, Fu YX J. Clin. Invest. 2018 Feb 128 2 580-588
Safety and efficacy of concurrent immune checkpoint inhibitors and hypofractionated body radiotherapy.
Mohamad O, Diaz de Leon A, Schroeder S, Leiker A, Christie A, Zhang-Velten E, Trivedi L, Khan S, Desai NB, Laine A, Albuquerque K, Iyengar P, Arriaga Y, Courtney K, Gerber DE, Hammers H, Choy H, Timmerman R, Brugarolas J, Hannan R Oncoimmunology 2018 7 7 e1440168
Safety and Efficacy of Stereotactic Ablative Radiation Therapy for Renal Cell Carcinoma Extracranial Metastases.
Wang CJ, Christie A, Lin MH, Jung M, Weix D, Huelsmann L, Kuhn K, Meyer J, Desai N, Kim DWN, Pedrosa I, Margulis V, Cadeddu J, Sagalowsky A, Gahan J, Laine A, Xie XJ, Choy H, Brugarolas J, Timmerman R, Hannan R Int. J. Radiat. Oncol. Biol. Phys. 2017 May 98 1 91-100
Pretreatment biopsy analysis of DAB2IP identifies subpopulation of high-risk prostate cancer patients with worse survival following radiation therapy.
Jacobs C, Tumati V, Kapur P, Yan J, Xie XJ, Hannan R, Hsieh JT, Kim DW, Saha D Cancer Med 2015 Oct
A Phase I Dose-Escalation Trial of Single-Fraction Stereotactic Radiation Therapy for Liver Metastases.
Meyer JJ, Foster RD, Lev-Cohain N, Yokoo T, Dong Y, Schwarz RE, Rule W, Tian J, Xie Y, Hannan R, Nedzi L, Solberg T, Timmerman R Ann. Surg. Oncol. 2015 May

Honors & Awards

  • Radiation and Cancer Biology Poster Award
    ASTRO 52nd Annual Meeting (2010)
  • US Patent
    Pancreatic Cancer-Associated Antigen, Antibody thereto, and Diagnostic and Treatment Methods – Development of a PaCa-Ag1-Specific Enzyme-Linked Immuno-Assay (2006)
  • International Patent
    Pancreatic Cancer-Associated Antigen, Antibody thereto, and Diagnostic and Treatment Methods (2005)

Professional Associations/Affiliations

  • American Society of Clinical Oncology
  • American Society of Therapeutic Radiology and Oncology