Dr. Garg and his collaborators at the National Institutes of Diabetes, Digestive and Kidney Diseases, NIH reported beneficial effects of leptin replacement therapy on glycemic control, lipoprotein levels and hepatic steatosis in patients with severe lipodystrophy and leptin deficiency. This study was published in the New England Journal of Medicine. Leptin is a hormone produced by the adipose tissue (body fat) and regulates appetite and energy expenditure. This landmark study supports the role of leptin deficiency as a major contributor to the insulin resistance and other metabolic abnormalities seen in severe lipodystrophy. Furthermore, leptin therapy may become the choice of therapy for treating these severely insulin resistant patients with lipodystrophies. Dr. Garg is now initiating studies to investigate whether leptin therapy will improve metabolic complication in hypoleptinemic patients with partial lipodystrophies. Recently, he identified two patterns of lipodystrophy in patients with mandibuloacral dysplasia which has led him to identify another gene, ZMPSTE24 besides LMNA, for this disorder.

More of Dr. Garg's accomplishments can be found on the Lipodystrophy Info website.


All India Institute of Medical Sciences, India (1978), Rotatory
Medical School
All India Institute of Medical Sciences, India (1982)
All India Institute of Medical Sciences, India (1983), Internal Medicine
University of Alabama at Birmingham School of Medicine (1985), Endocrinology & Metabolism
UT Southwestern Medical Center (1987), Endocrinology & Metabolism

Research Interest

  • Diabetes
  • Disorders of Adipose Tissue
  • Insulin Resistance


Featured Publications LegendFeatured Publications

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For a complete listing of publications for Dr. Garg

Honors & Awards

  • Silver Jubilee Oration Award
    All India Institute of Medical Sciences (2003)
  • Endowed Chair in Human Nutrition Research
    UT Southwestern (2001)
  • Member
    American Society for Clinical Investigation (2000)
  • Keynote Speaker
    XXXVIII Annual Meeting of the Mexican Society of Endocrinology (1998)
  • Keynote Speaker
    8th Japan Diabetes-Lipid Research Seminar (1991)

Professional Associations/Affiliations

  • American Diabetes Association
  • American Federation of Medical Research
  • American Heart Association
  • American Society of Clinical Investigation