Boning Gao, Ph.D.

• The goal of my research is to establish pre-clinical models for the identification and characterization of oncogene and tumor suppressor genes and for the discovery of drugs for target therapy in lung cancer.

 Featured Publications

Contrasting interferon-mediated antiviral responses in human lung adenocarcinoma cells.

Esparza M, El Zahed SS, Karakus U, Niederstrasser H, Gao B, Batten K, Shay JW, Posner B, Hirsch FR, Girard L, Huang LJ-s, Minna J, García-Sastre A, Fontoura BMA, J Virol 2025 May e0046925

SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition.

Song X, Zhou Z, Elmezayen A, Wu R, Yu C, Gao B, Minna JD, Westover KD, Zeh HJ, Kroemer G, Heasley LE, Kang R, Tang D, Sci Adv 2024 Dec 10 50 eadq4274

IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells.

Nawas AF, Solmonson A, Gao B, DeBerardinis RJ, Minna JD, Conacci-Sorrell M, Mendelson CR, Cell Commun Signal 2023 Nov 21 1 331

Unexpected Differences in the Speed of Non-Malignant versus Malignant Cell Migration Reveal Differential Basal Intracellular ATP Levels.

Kim B, Lopez AT, Thevarajan I, Osuna MF, Mallavarapu M, Gao B, Osborne JK, Cancers (Basel) 2023 Nov 15 23

Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma.

Kwok HH, Li H, Yang J, Deng J, Lee NC, Au TW, Sit AK, Hsin MK, Ma SK, Cheung LW, Girard L, Fujimoto J, Wistuba II, Gao B, Minna JD, Lam DC, Cancer Commun (Lond) 2023 Jun

Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.

Iyengar P, Gandhi AY, Granados J, Guo T, Gupta A, Yu J, Llano EM, Zhang F, Gao A, Kandathil A, Williams D, Gao B, Girard L, Malladi VS, Shelton JM, Evers BM, Hannan R, Ahn C, Minna JD, Infante RE, JCI Insight 2023 Apr 8 8

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.

Bartolacci C, Andreani C, Vale G, Berto S, Melegari M, Crouch AC, Baluya DL, Kemble G, Hodges K, Starrett J, Politi K, Starnes SL, Lorenzini D, Raso MG, Solis Soto LM, Behrens C, Kadara H, Gao B, Wistuba II, Minna JD, McDonald JG, Scaglioni PP, Nat Commun 2022 Jul 13 1 4327

Phosphatidylserine receptors enhance SARS-CoV-2 infection.

Bohan D, Van Ert H, Ruggio N, Rogers KJ, Badreddine M, Aguilar Briseño JA, Elliff JM, Rojas Chavez RA, Gao B, Stokowy T, Christakou E, Kursula P, Micklem D, Gausdal G, Haim H, Minna J, Lorens JB, Maury W, PLoS Pathog 2021 Nov 17 11 e1009743

Nicotinic Acetylcholine Receptor Subunit a7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.

Kwok HH, Gao B, Chan KH, Ip MS, Minna JD, Lam DC, Cancers (Basel) 2021 Oct 13 21

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology.

Stewart CA, Gay CM, Ramkumar K, Cargill KR, Cardnell RJ, Nilsson MB, Heeke S, Park EM, Kundu ST, Diao L, Wang Q, Shen L, Xi Y, Zhang B, Della Corte CM, Fan Y, Kundu K, Gao B, Avila K, Pickering CR, Johnson FM, Zhang J, Kadara H, Minna JD, Gibbons DL, Wang J, Heymach JV, Byers LA, J Thorac Oncol 2021 Jul