Education

Undergraduate
Fudan University (1999), Microbiology
Graduate School
University of Texas at Austin (2006), Molecular Biology

Research Interest

  • Autoimmune diseases
  • Cancer immunology
  • Glycoimmunology
  • Host pathogen interactions
  • Innate immunity

Publications

Featured Publications LegendFeatured Publications

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N Nat. Immunol. 2013 Jan 14 1 61-71
SAMHD1 does it again, now in resting T cells.
Yan N, Lieberman J Nat. Med. 2012 Nov 18 11 1611-2
Intrinsic antiviral immunity.
Yan N, Chen ZJ Nat. Immunol. 2012 Mar 13 3 214-22
HIV DNA is heavily uracilated, which protects it from autointegration.
Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J Proc. Natl. Acad. Sci. U.S.A. 2011 May 108 22 9244-9
Gaining a foothold: how HIV avoids innate immune recognition.
Yan N, Lieberman J Curr. Opin. Immunol. 2011 Feb 23 1 21-8
The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.
Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J Nat. Immunol. 2010 Nov 11 11 1005-13
The SET complex acts as a barrier to autointegration of HIV-1.
Yan N, Cherepanov P, Daigle JE, Engelman A, Lieberman J PLoS Pathog. 2009 Mar 5 3 e1000327
Identification of host proteins required for HIV infection through a functional genomic screen.
Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ Science 2008 Feb 319 5865 921-6

Honors & Awards

  • Burroughs Wellcome PATH Investigator
    (2015)
  • Endowed Scholar Award, UTSW
    (2011)
  • NIAID Career Development Award
    (2011)
  • Young Investigator Award, CORI
    (2008)
  • Center for AIDS Research (CFAR) Scholar Award
    (2007)