Nan Yan, Ph.D.

Vice Chair

Professor

Endowed Title: Edwin L. Cox Distinguished Chair in Immunology and Genetics; Rita C. and William P. Clements, Jr. Scholar in Medical Research
School: Medical School
Department: Immunology | Microbiology
Graduate Programs: Immunology, Molecular Microbiology

Biography

The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune disease, cancer immunology, and neurodegenerative disease. We are also interested in inborn errors of innate immunity, mechanisms of disease, and preclinical testing of therapeutics that target innate immune signaling pathways.

More details at: Yan Lab Website

Education

Research Interest

Publications

Featured Publications

Interruption of post-Golgi STING trafficking activates tonic interferon signaling.: Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N, Nat Commun 2022 Nov 13 1 6977
The mammalian SKIV2L RNA exosome is essential for early B cell development.: Yang K, Han J, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki C, de la Morena MT, Yan N, Sci Immunol 2022 Jun 7 72 eabn2888
Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.: Yang K, Han J, Asada M, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki CA, de la Morena MT, Garza LA, Yan N, J Clin Invest 2022 Jan 132 2
No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon.: Wu J, Yan N, J Mol Biol 2021 Oct 167257
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.: Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N, Nature 2021 Jul
Reactive oxygen species oxidize STING and suppress interferon production.: Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA, Elife 2020 09 9
Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.: Wu J, Dobbs N, Yang K, Yan N, Immunity 2020 Jul
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.: Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N, Nat. Immunol. 2020 Jan
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.: Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N, Nat Commun 2019 May 10 1 2377
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.: Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N J. Exp. Med. 2019 Mar

Honors & Awards