Nan Yan, Ph.D. Titles and Appointments Vice Chair Professor Endowed Title Edwin L. Cox Distinguished Chair in Immunology and Genetics; Rita C. and William P. Clements, Jr. Scholar in Medical Research School Medical School Department Immunology | Microbiology Graduate Programs Immunology, Molecular Microbiology Biography The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune disease, cancer immunology, and neurodegenerative disease. We are also interested in inborn errors of innate immunity, mechanisms of disease, and preclinical testing of therapeutics that target innate immune signaling pathways. More details at: Yan Lab Website Education Undergraduate Fudan University (1999), Microbiology Graduate School University of Texas-Austin (2006), Molecular Biology Research Interest Innate immunity and autoimmune disease Neuroimmunology, neurodegeneration Nucleic acid sensing, type I interferon signaling Rare disease, inborn errors of immunity RNA exosome biology Publications Featured Publications PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease. Jeltema D, Knox K, Dobbs N, Tang Z, Xing C, Araskiewicz A, Yang K, Siordia IR, Matthews J, Cohen M, Yan N, J Exp Med 2025 May 222 5 Targeting Innate Immune Checkpoint TREX1 is a Safe and Effective Immunotherapeutic Strategy in Cancer. Xing C, Tu X, Huai W, Tang Z, Song K, Jeltema D, Knox K, Dobbs N, Yang K, Yan N, Cancer Res 2025 May STING: a multifaced player in cellular homeostasis. Song K, Heng L, Yan N, Hum Mol Genet 2025 Apr Dynamic STING repression orchestrates immune cell development and function. Knox K, Jeltema D, Dobbs N, Yang K, Xing C, Song K, Tang Z, Torres-Ramirez G, Wang J, Gao S, Wu T, Yao C, Wang J, Yan N, Sci Immunol 2025 Mar 10 105 eado9933 STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders. Tang Z, Xing C, Araszkiewicz A, Yang K, Huai W, Jeltema D, Dobbs N, Zhang Y, Sun LO, Yan N, Mol Cell 2025 Mar OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity. Huai W, Yang K, Xing C, Song K, Lyu H, Williams NS, Wu J, Yan N, Immunity 2025 Feb γδ T Cell-mediated Tumor Immunity is Tightly Regulated by STING and TGF-β Signaling Pathways. Luo J, Wang S, Yang Q, Fu Q, Zhu C, Li T, Yang S, Zhao Y, Guo R, Ben X, Zheng Y, Li S, Yang G, Zhang H, Xiao H, Jiang Z, Yan N, Kabelitz D, Sun G, Granot Z, Lu L, You F, Hao J, Yin Z, Adv Sci (Weinh) 2024 Nov e2404432 RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway. Yang K, Dong B, Asthana A, Silverman RH, Yan N, EMBO J 2024 Aug Systemic gene therapy corrects neurological phenotype in a mouse model of NGLY1 deficiency. Du A, Yang K, Zhou X, Ren L, Liu N, Zhou C, Liang J, Yan N, Gao G, Wang D, JCI Insight 2024 Aug STING licensing of type I dendritic cells potentiates antitumor immunity. Wang J, Li S, Wang M, Wang X, Chen S, Sun Z, Ren X, Huang G, Sumer BD, Yan N, Fu YX, Gao J, Sci Immunol 2024 Feb 9 92 eadj3945 Results 1-10 of 49 1 2 3 4 5 Next Last Honors & Awards Burroughs Wellcome PATH Investigator (2015) Endowed Scholar Award, UTSW (2011) NIAID Career Development Award (2011)
