Nan Yan, Ph.D.

The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune disease, cancer immunology, and neurodegenerative disease. We are also interested in other inborn errors of innate immunity, mechanisms of disease, and preclinical testing of therapeutics that target innate immune signaling pathways. More details at: Yan Lab Website

Undergraduate

Fudan University (1999), Microbiology

Graduate School

University of Texas at Austin (2006), Molecular Biology

• Innate immunity and autoimmune disease
• Neuroimmunology
• Nucleic acid sensing, type I interferon signaling
• Rare disease, inborn errors of immunity
• RNA exosome biology

Featured Publications

Bilayer STING goes head to head to stay put.

Yang K, Yan N, Mol Cell 2023 May 83 9 1372-1374

STING trafficking as a new dimension of immune signaling.

Jeltema D, Abbott K, Yan N, J Exp Med 2023 Mar 220 3

Interruption of post-Golgi STING trafficking activates tonic interferon signaling.

Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N, Nat Commun 2022 Nov 13 1 6977

The mammalian SKIV2L RNA exosome is essential for early B cell development.

Yang K, Han J, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki C, de la Morena MT, Yan N, Sci Immunol 2022 Jun 7 72 eabn2888

Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.

Yang K, Han J, Asada M, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki CA, de la Morena MT, Garza LA, Yan N, J Clin Invest 2022 Jan 132 2

No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon.

Wu J, Yan N, J Mol Biol 2021 Oct 167257

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.

Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N, Nature 2021 Jul

Reactive oxygen species oxidize STING and suppress interferon production.

Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA, Elife 2020 09 9

Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.

Wu J, Dobbs N, Yang K, Yan N, Immunity 2020 Jul

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.

Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N, Nat. Immunol. 2020 Jan

• Burroughs Wellcome PATH Investigator
  (2015)
• Endowed Scholar Award, UTSW
  (2011)
• NIAID Career Development Award
  (2011)
• Young Investigator Award, CORI
  (2008)
• Center for AIDS Research (CFAR) Scholar Award
  (2007)