Education

Undergraduate
Fudan University (1999), Microbiology
Graduate School
University of Texas at Austin (2006), Molecular Biology

Research Interest

  • Cancer immunology
  • Innate immunity and autoimmune disease
  • Neuroimmunology
  • Nucleic acid sensing, type I interferon signaling
  • Rare disease, inborn errors of immunity

Publications

Featured Publications LegendFeatured Publications

The mammalian SKIV2L RNA exosome is essential for early B cell development.
Yang K, Han J, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki C, de la Morena MT, Yan N, Sci Immunol 2022 Jun 7 72 eabn2888
Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.
Yang K, Han J, Asada M, Gill JG, Park JY, Sathe MN, Gattineni J, Wright T, Wysocki CA, de la Morena MT, Garza LA, Yan N, J Clin Invest 2022 Jan 132 2
No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon.
Wu J, Yan N, J Mol Biol 2021 Oct 167257
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N, Nature 2021 Jul
Reactive oxygen species oxidize STING and suppress interferon production.
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA, Elife 2020 09 9
Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.
Wu J, Dobbs N, Yang K, Yan N, Immunity 2020 Jul
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N, Nat. Immunol. 2020 Jan
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.
Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N, Nat Commun 2019 May 10 1 2377
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N J. Exp. Med. 2019 Mar
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.
Lu H, Fermaintt CS, Cherepanova NA, Gilmore R, Yan N, Lehrman MA Proc. Natl. Acad. Sci. U.S.A. 2018 Sep

Honors & Awards

  • Burroughs Wellcome PATH Investigator
    (2015)
  • Endowed Scholar Award, UTSW
    (2011)
  • NIAID Career Development Award
    (2011)
  • Young Investigator Award, CORI
    (2008)
  • Center for AIDS Research (CFAR) Scholar Award
    (2007)