Education

Undergraduate
Fudan University (1999), Microbiology
Graduate School
University of Texas at Austin (2006), Molecular Biology

Research Interest

  • Cancer immunology
  • Innate immunity and autoimmune disease
  • Neuro immunology
  • nucleic acid sensing, type I interferon signaling

Publications

Featured Publications LegendFeatured Publications

Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N, Nature 2021 Jul
Reactive oxygen species oxidize STING and suppress interferon production.
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA, Elife 2020 09 9
Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion.
Wu J, Dobbs N, Yang K, Yan N, Immunity 2020 Jul
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N, Nat. Immunol. 2020 Jan
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.
Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N, Nat Commun 2019 May 10 1 2377
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N J. Exp. Med. 2019 Mar
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.
Lu H, Fermaintt CS, Cherepanova NA, Gilmore R, Yan N, Lehrman MA Proc. Natl. Acad. Sci. U.S.A. 2018 Sep
N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.
Yang K, Huang R, Fujihira H, Suzuki T, Yan N J. Exp. Med. 2018 Aug
Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015.
Aroh C, Liang C, Raj P, Wakeland B, Yan N, Wakeland E Infect. Genet. Evol. 2018 Aug
Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.
Gonugunta VK, Sakai T, Pokatayev V, Yang K, Wu J, Dobbs N, Yan N Cell Rep 2017 Dec 21 11 3234-3242

Honors & Awards

  • Burroughs Wellcome PATH Investigator
    (2015)
  • Endowed Scholar Award, UTSW
    (2011)
  • NIAID Career Development Award
    (2011)
  • Young Investigator Award, CORI
    (2008)
  • Center for AIDS Research (CFAR) Scholar Award
    (2007)