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Nan Yan, Ph.D.

Nan Yan, Ph.D.

Titles and Appointments

Vice Chair

Professor

Endowed Title
Edwin L. Cox Distinguished Chair in Immunology and Genetics; Rita C. and William P. Clements, Jr. Scholar in Medical Research
School
Medical School
Department
Immunology | Microbiology
Graduate Programs
Immunology, Molecular Microbiology
  • Biography

    The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune disease, cancer immunology, and neurodegenerative disease. We are also interested in inborn errors of innate immunity, mechanisms of disease, and preclinical testing of therapeutics that target innate immune signaling pathways.

    More details at: Yan Lab Website

  • Education
    Undergraduate
    Fudan University (1999), Microbiology
    Graduate School
    University of Texas-Austin (2006), Molecular Biology
  • Research Interest
    • Innate immunity and autoimmune disease
    • Neuroimmunology, neurodegeneration
    • Nucleic acid sensing, type I interferon signaling
    • Rare disease, inborn errors of immunity
    • RNA exosome biology
  • Publications

    Star Featured Publications

    PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease.
    Jeltema D, Knox K, Dobbs N, Tang Z, Xing C, Araskiewicz A, Yang K, Siordia IR, Matthews J, Cohen M, Yan N, J Exp Med 2025 May 222 5
    STING: a multifaced player in cellular homeostasis.
    Song K, Heng L, Yan N, Hum Mol Genet 2025 Apr
    Dynamic STING repression orchestrates immune cell development and function.
    Knox K, Jeltema D, Dobbs N, Yang K, Xing C, Song K, Tang Z, Torres-Ramirez G, Wang J, Gao S, Wu T, Yao C, Wang J, Yan N, Sci Immunol 2025 Mar 10 105 eado9933
    STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders.
    Tang Z, Xing C, Araszkiewicz A, Yang K, Huai W, Jeltema D, Dobbs N, Zhang Y, Sun LO, Yan N, Mol Cell 2025 Mar
    OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity.
    Huai W, Yang K, Xing C, Song K, Lyu H, Williams NS, Wu J, Yan N, Immunity 2025 Feb
    γδ T Cell-mediated Tumor Immunity is Tightly Regulated by STING and TGF-β Signaling Pathways.
    Luo J, Wang S, Yang Q, Fu Q, Zhu C, Li T, Yang S, Zhao Y, Guo R, Ben X, Zheng Y, Li S, Yang G, Zhang H, Xiao H, Jiang Z, Yan N, Kabelitz D, Sun G, Granot Z, Lu L, You F, Hao J, Yin Z, Adv Sci (Weinh) 2024 Nov e2404432
    RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway.
    Yang K, Dong B, Asthana A, Silverman RH, Yan N, EMBO J 2024 Aug
    Systemic gene therapy corrects neurological phenotype in a mouse model of NGLY1 deficiency.
    Du A, Yang K, Zhou X, Ren L, Liu N, Zhou C, Liang J, Yan N, Gao G, Wang D, JCI Insight 2024 Aug
    STING licensing of type I dendritic cells potentiates antitumor immunity.
    Wang J, Li S, Wang M, Wang X, Chen S, Sun Z, Ren X, Huang G, Sumer BD, Yan N, Fu YX, Gao J, Sci Immunol 2024 Feb 9 92 eadj3945
    Innate immune sensing of macromolecule homeostasis.
    Yang K, Jeltema D, Yan N, Adv Immunol 2024 161 17-51
  • Honors & Awards
    • Burroughs Wellcome PATH Investigator
      (2015)
    • Endowed Scholar Award, UTSW
      (2011)
    • NIAID Career Development Award
      (2011)