Fudan University (1999), Microbiology
Graduate School
University of Texas at Austin (2006), Molecular Biology

Research Interest

  • Autoimmune diseases
  • Cancer immunology
  • Glycoimmunology
  • Host pathogen interactions
  • Innate immunity


Featured Publications LegendFeatured Publications

A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response.
Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N, Nat Commun 2019 May 10 1 2377
STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death.
Wu J, Chen YJ, Dobbs N, Sakai T, Liou J, Miner JJ, Yan N J. Exp. Med. 2019 Mar
Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis.
Lu H, Fermaintt CS, Cherepanova NA, Gilmore R, Yan N, Lehrman MA Proc. Natl. Acad. Sci. U.S.A. 2018 Sep
N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.
Yang K, Huang R, Fujihira H, Suzuki T, Yan N J. Exp. Med. 2018 Aug
Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015.
Aroh C, Liang C, Raj P, Wakeland B, Yan N, Wakeland E Infect. Genet. Evol. 2018 Aug
Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response.
Gonugunta VK, Sakai T, Pokatayev V, Yang K, Wu J, Dobbs N, Yan N Cell Rep 2017 Dec 21 11 3234-3242
Innate Immune Activation by cGMP-AMP Nanoparticles Leads to Potent and Long-Acting Antiretroviral Response against HIV-1.
Aroh C, Wang Z, Dobbs N, Luo M, Chen Z, Gao J, Yan N J. Immunol. 2017 Oct
STING-associated vasculopathy develops independently of IRF3 in mice.
Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Wu J, Platt DJ, Yan N, Miner JJ J. Exp. Med. 2017 Sep
Immune Diseases Associated with TREX1 and STING Dysfunction.
Yan N J. Interferon Cytokine Res. 2017 May 37 5 198-206
Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex.
Kucej M, Fermaintt CS, Yang K, Irizarry-Caro RA, Yan N Cell Rep 2017 Mar 18 11 2600-2607

Honors & Awards

  • Burroughs Wellcome PATH Investigator
  • Endowed Scholar Award, UTSW
  • NIAID Career Development Award
  • Young Investigator Award, CORI
  • Center for AIDS Research (CFAR) Scholar Award