Michael Shiloh, M.D., Ph.D.

Michael Shiloh, M.D., Ph.D., is an Associate Professor with tenure in the Departments of Internal Medicine and Microbiology at UT Southwestern Medical Center and a member of the Division of Infectious Diseases and Geographic Medicine. He holds the James P. Luby, M.D. Professorship in Infectious Diseases.

Dr. Shiloh earned a bachelor's degree with honors in chemistry from Pennsylvania State University in State College. He received his medical degree and his doctorate in immunology at Cornell University in New York. He then completed internal medicine residency training, a fellowship in infectious diseases, and a molecular medicine fellowship at the University of California San Francisco.

Certified by the American Board of Internal Medicine in internal medicine and in infectious diseases, Dr. Shiloh joined the UT Southwestern faculty in 2011 as an Assistant Professor. He was promoted to Associate Professor with tenure in 2018.

At UT Southwestern, Dr. Shiloh is a member of the Biosafety Committee and the Medical Scientist Training Program Steering Committee. He's also a member of several professional societies, including the Infectious Disease Society of America, the American Society of Microbiology, the American Association of Immunologists, and the American Society of Clinical Investigation.

Dr. Shiloh's research interests include tuberculosis, immunology, and microbiology. In his laboratory, his long-term research goal is to discover the mechanisms by which Mycobacterium tuberculosis (Mtb) causes disease in humans. His findings have resulted in numerous peer-reviewed publications, invited lectures, reviews, and book chapters.

Personal Note

Outside of work, Dr. Shiloh enjoys hiking, running, playing soccer, traveling, and cooking.

Medical School

Cornell University Medical College (2001)

Residency

University of California, San Francisco (2003), Internal Medicine

Fellowship

University of California at San Francisco (2007), Infectious Diseases

• Autophagy
• Innate Immune Response to Intracellular Pathogens
• Microbial Pathogenesis
• Mucosal Immunology
• Mycobacterium Tuberculosis
• Neuroimmunology

Featured Publications

CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses.

Thinwa JW, Zou Z, Parks E, Sebti S, Hui KK, Wei Y, Goodarzi M, Singh V, Urquhart G, Jewell JL, Pfeiffer JK, Levine B, Reese TA, Shiloh MU, J Clin Invest 2023 Nov

Infectious and Inflammatory Pathways to Cough.

Naqvi KF, Mazzone SB, Shiloh MU, Annu Rev Physiol 2022 Sep

Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis.

Khan HS, Nair VR, Ruhl CR, Alvarez-Arguedas S, Galvan Rendiz JL, Franco LH, Huang L, Shaul PW, Kim J, Xie Y, Mitchell RB, Shiloh MU, Elife 2020 Mar 9

Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough.

Ruhl CR, Pasko BL, Khan HS, Kindt LM, Stamm CE, Franco LH, Hsia CC, Zhou M, Davis CR, Qin T, Gautron L, Burton MD, Mejia GL, Naik DK, Dussor G, Price TJ, Shiloh MU, Cell 2020 Mar

Screening Mycobacterium tuberculosis Secreted Proteins Identifies Mpt64 as a Eukaryotic Membrane-Binding Bacterial Effector.

Stamm CE, Pasko BL, Chaisavaneeyakorn S, Franco LH, Nair VR, Weigele BA, Alto NM, Shiloh MU, mSphere 2019 Jun 4 3

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.

Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B Cell Host Microbe 2016 Dec

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.

Nair VR, Franco LH, Zacharia VM, Khan HS, Stamm CE, You W, Marciano DK, Yagita H, Levine B, Shiloh MU Cell Rep 2016 Jul

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.

Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU Cell Host Microbe 2015 Jun

Pathogenicity and virulence of Mycobacterium tuberculosis.

Rahlwes KC, Dias BRS, Campos PC, Alvarez-Arguedas S, Shiloh MU, Virulence 2023 Dec 14 1 2150449

BECN1^F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.

Sebti S, Zou Z, Shiloh MU, Autophagy 2022 Aug 1-9

 Featured Books

Infectious Diseases. In Hospitalist Handbook

Marciano D, Shiloh MU, Newman M. (2002). San Francisco, University of California at San Francisco

Antimicrobial Mechanisms of Macrophages. In Phagocytosis: The Host

Shiloh, MU and Nathan, C (1999). Greenwich, CT, JAI Press

• American Society of Clinical Investigation
  Member (2021)
• Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases
  (2018-2023)
• The Department of Internal Medicine Chair's Pilot Awards
  A Synthetic Lethal Genetic Interaction Map in Mycobacterium tuberculosis (2015-2017)
• UTSW High Impact/High Risk Award
  Research award for development of a novel M. tuberculosis vaccine (2012)
• Disease Oriented Clinical Scholar, UTSW
  (2011)
• NIH/NIAID K08 award
  2008-2012 (2008)
• Sandler Family Foundation Discovery Award
  Research award for highly innovative research (2006)
• Giannini Family Foundation Research Fellowship, 2005-2008
  Honors research fellows in the state of California (2005)

• American Association of Immunologists (2014)
• American Society of Clinical Investigation (2021)
• American Society of Microbiology (2013)
• Infectious Disease Society of America (2010)