Michael Shiloh, M.D., Ph.D. Titles and Appointments Professor Endowed Title James P. Luby, M.D. Professorship in Infectious Diseases School Medical School Department Internal Medicine | Microbiology Graduate Programs Immunology, Molecular Microbiology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Michael Shiloh, M.D., Ph.D., is a Professor with tenure in the Departments of Internal Medicine and Microbiology at UT Southwestern Medical Center and a member of the Division of Infectious Diseases and Geographic Medicine. He holds the James P. Luby, M.D. Professorship in Infectious Diseases. Dr. Shiloh earned a bachelor's degree with honors in chemistry from Pennsylvania State University in State College. He received his medical degree and his doctorate in immunology at Cornell University in New York. He then completed internal medicine residency training, a fellowship in infectious diseases, and a molecular medicine fellowship at the University of California San Francisco. Certified by the American Board of Internal Medicine in internal medicine and in infectious diseases, Dr. Shiloh joined the UT Southwestern faculty in 2011 as an Assistant Professor. He was promoted to Associate Professor with tenure in 2018. At UT Southwestern, Dr. Shiloh is a member of the Biosafety Committee and the Medical Scientist Training Program Steering Committee. He's also a member of several professional societies, including the Infectious Disease Society of America, the American Society of Microbiology, the American Association of Immunologists, and the American Society of Clinical Investigation. Dr. Shiloh's research interests include tuberculosis, immunology, and microbiology. In his laboratory, his long-term research goal is to discover the mechanisms by which Mycobacterium tuberculosis (Mtb) causes disease in humans. His findings have resulted in numerous peer-reviewed publications, invited lectures, reviews, and book chapters. Personal Note Outside of work, Dr. Shiloh enjoys hiking, running, playing soccer, traveling, and cooking. Education Medical School Cornell University Medical College (2001) Residency University of California, San Francisco (2003), Internal Medicine Fellowship University of California at San Francisco (2007), Infectious Diseases Research Interest Autophagy Innate Immune Response to Intracellular Pathogens Microbial Pathogenesis Mucosal Immunology Mycobacterium Tuberculosis Neuroimmunology Publications Featured Publications An alveolus lung-on-a-chip model of Mycobacterium fortuitum lung infection. Ektnitphong V, Dias BRS, Campos PC, Shiloh MU, Dis Model Mech 2025 Sep 18 9 Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells. Alvarez-Arguedas S, Mazhar K, Wangzhou A, Sankaranarayanan I, Gaona G, Lafin JT, Mitchell RB, Price TJ, Shiloh MU, Mucosal Immunol 2025 Jul CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses. Thinwa JW, Zou Z, Parks E, Sebti S, Hui KK, Wei Y, Goodarzi M, Singh V, Urquhart G, Jewell JL, Pfeiffer JK, Levine B, Reese TA, Shiloh MU, J Clin Invest 2023 Nov Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis. Khan HS, Nair VR, Ruhl CR, Alvarez-Arguedas S, Galvan Rendiz JL, Franco LH, Huang L, Shaul PW, Kim J, Xie Y, Mitchell RB, Shiloh MU, Elife 2020 Mar 9 Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough. Ruhl CR, Pasko BL, Khan HS, Kindt LM, Stamm CE, Franco LH, Hsia CC, Zhou M, Davis CR, Qin T, Gautron L, Burton MD, Mejia GL, Naik DK, Dussor G, Price TJ, Shiloh MU, Cell 2020 Mar The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense. Franco LH, Nair VR, Scharn CR, Xavier RJ, Torrealba JR, Shiloh MU, Levine B Cell Host Microbe 2016 Dec Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. Collins AC, Cai H, Li T, Franco LH, Li XD, Nair VR, Scharn CR, Stamm CE, Levine B, Chen ZJ, Shiloh MU Cell Host Microbe 2015 Jun Pathogenicity and virulence of Mycobacterium tuberculosis. Rahlwes KC, Dias BRS, Campos PC, Alvarez-Arguedas S, Shiloh MU, Virulence 2023 Dec 14 1 2150449 Infectious and Inflammatory Pathways to Cough. Naqvi KF, Mazzone SB, Shiloh MU, Annu Rev Physiol 2022 Sep BECN1F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner. Sebti S, Zou Z, Shiloh MU, Autophagy 2022 Aug 1-9 Results 1-10 of 34 1 2 3 4 Next Last Books Featured Books Infectious Diseases. In Hospitalist Handbook Marciano D, Shiloh MU, Newman M. (2002). San Francisco, University of California at San Francisco Antimicrobial Mechanisms of Macrophages. In Phagocytosis: The Host Shiloh, MU and Nathan, C (1999). Greenwich, CT, JAI Press Honors & Awards American Society of Clinical InvestigationMember (2021) Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases (2018-2023) The Department of Internal Medicine Chair's Pilot AwardsA Synthetic Lethal Genetic Interaction Map in Mycobacterium tuberculosis (2015-2017) UTSW High Impact/High Risk AwardResearch award for development of a novel M. tuberculosis vaccine (2012) Disease Oriented Clinical Scholar, UTSW (2011) NIH/NIAID K08 award2008-2012 (2008) Sandler Family Foundation Discovery AwardResearch award for highly innovative research (2006) Giannini Family Foundation Research Fellowship, 2005-2008Honors research fellows in the state of California (2005) Professional Associations/Affiliations American Association of Immunologists (2014) American Society of Clinical Investigation (2021) American Society of Microbiology (2013) Infectious Disease Society of America (2010)
