Michael Shiloh, M.D., Ph.D., is an Associate Professor with tenure in the Departments of Internal Medicine and Microbiology at UT Southwestern Medical Center and a member of the Division of Infectious Diseases and Geographic Medicine. He holds the James P. Luby, M.D. Professorship in Infectious Diseases.

Dr. Shiloh earned a bachelor's degree with honors in chemistry from Pennsylvania State University in State College. He received his medical degree and his doctorate in immunology at Cornell University in New York. He then completed internal medicine residency training, a fellowship in infectious diseases, and a molecular medicine fellowship at the University of California San Francisco.

Certified by the American Board of Internal Medicine in internal medicine and in infectious diseases, Dr. Shiloh joined the UT Southwestern faculty in 2011 as an Assistant Professor. He was promoted to Associate Professor with tenure in 2018.

At UT Southwestern, Dr. Shiloh is a member of the Biosafety Committee and the Medical Scientist Training Program Steering Committee. He's also a member of several professional societies, including the Infectious Disease Society of America, the American Society of Microbiology, the American Association of Immunologists, and the American Society of Clinical Investigation.

Dr. Shiloh's research interests include tuberculosis, immunology, and microbiology. In his laboratory, his long-term research goal is to discover the mechanisms by which Mycobacterium tuberculosis (Mtb) causes disease in humans. His findings have resulted in numerous peer-reviewed publications, invited lectures, reviews, and book chapters.

Personal Note

Outside of work, Dr. Shiloh enjoys hiking, running, playing soccer, traveling, and cooking.


Medical School
Cornell University Medical College (2001)
University of California, San Francisco (2003), Internal Medicine
University of California at San Francisco (2007), Infectious Diseases

Research Interest

  • Autophagy
  • Innate Immune Response to Intracellular Pathogens
  • Microbial Pathogenesis
  • Mucosal Immunology
  • Mycobacterium Tuberculosis
  • Neuroimmunology


Featured Publications LegendFeatured Publications

Pathogenicity and virulence of Mycobacterium tuberculosis.
Rahlwes KC, Dias BRS, Campos PC, Alvarez-Arguedas S, Shiloh MU, Virulence 2023 Dec 14 1 2150449
BECN1F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.
Sebti S, Zou Z, Shiloh MU, Autophagy 2022 Aug 1-9


Featured Books Legend Featured Books

Honors & Awards

  • American Society of Clinical Investigation
    Member (2021)
  • Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases
  • The Department of Internal Medicine Chair's Pilot Awards
    A Synthetic Lethal Genetic Interaction Map in Mycobacterium tuberculosis (2015-2017)
  • UTSW High Impact/High Risk Award
    Research award for development of a novel M. tuberculosis vaccine (2012)
  • Disease Oriented Clinical Scholar, UTSW
  • NIH/NIAID K08 award
    2008-2012 (2008)
  • Sandler Family Foundation Discovery Award
    Research award for highly innovative research (2006)
  • Giannini Family Foundation Research Fellowship, 2005-2008
    Honors research fellows in the state of California (2005)

Professional Associations/Affiliations

  • American Association of Immunologists (2014)
  • American Society of Clinical Investigation (2021)
  • American Society of Microbiology (2013)
  • Infectious Disease Society of America (2010)