Michael Shiloh, M.D., Ph.D. Titles and Appointments Professor Endowed Title James P. Luby, M.D. Professorship in Infectious Diseases Schools Medical School | Graduate School Departments Internal Medicine | Microbiology Graduate Programs Immunology, Molecular Microbiology You have reached the Academic Profile. For more information on the doctor and patient care, please visit the clinical profile. Biography Michael Shiloh, M.D., Ph.D., is a Professor with tenure in the Departments of Internal Medicine and Microbiology at UT Southwestern Medical Center and a member of the Division of Infectious Diseases and Geographic Medicine. He holds the James P. Luby, M.D. Professorship in Infectious Diseases. Dr. Shiloh earned a bachelor's degree with honors in chemistry from Pennsylvania State University in State College. He received his medical degree and his doctorate in immunology at Cornell University in New York. He then completed internal medicine residency training, a fellowship in infectious diseases, and a molecular medicine fellowship at the University of California San Francisco. Certified by the American Board of Internal Medicine in internal medicine and in infectious diseases, Dr. Shiloh joined the UT Southwestern faculty in 2011 as an Assistant Professor. He was promoted to Associate Professor with tenure in 2018 and Professor in 2025. At UT Southwestern, Dr. Shiloh is a member of the Institutional Biosafety Committee. He's also a member of several professional societies, including the Infectious Disease Society of America, the American Society of Microbiology, the American Association of Immunologists, and the American Society of Clinical Investigation. Dr. Shiloh is a physician-scientist whose laboratory studies the mechanisms by which Mycobacterium tuberculosis causes disease and spreads between hosts. In his laboratory, his research focuses on tuberculosis pathogenesis, mucosal and innate immunity, host-pathogen interactions, and the neurobiology and aerobiology of transmission. His research program has been continuously funded by the National Institutes of Health for more than 15 years. Personal Note Outside of work, Dr. Shiloh enjoys hiking, running, playing soccer, traveling, and cooking. Education Medical Education Cornell University Medical College (2001) Residency University of California, San Francisco (2003), Internal Medicine Fellowship University of California at San Francisco (2007), Infectious Diseases Research Interest Autophagy Innate Immune Response to Intracellular Pathogens Microbial Pathogenesis Mucosal Immunology Mycobacterium Tuberculosis Neuroimmunology Publications Featured Publications SMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages. Campos PC, Rahlwes KC, Ektnitphong VA, Dias BR, Naqvi KF, Alvarez-Arguedas S, Shiloh MU, JCI Insight 2026 Sep Airflow constraints govern natural airborne transmission of tuberculosis. Naqvi KF, Guo Y, Kulkarni Y, Sapkota D, Lu P, Wang S, Dias BRS, Ektnitphong VA, Martin AE, Evers BM, Lu LL, Ouyang H, Bourouiba L, Shiloh MU, mSphere 2026 Aug e0022826 Sorting nexin 5 deficiency impairs MHC class II antigen presentation and inflammatory responses during tuberculosis. Dias BRS, Naqvi KF, Ektnitphong VA, Alvarez-Arguedas S, Rahlwes KC, Campos PC, Shiloh MU, J Immunol 2026 Aug 215 8 Deubiquitinase USP15 restricts LC3-dependent targeting of Mycobacterium tuberculosis. Rahlwes KC, Campos PC, Dias BRS, Párraga Solórzano PK, Shiloh MU, Autophagy 2026 Jan 1-15 An alveolus lung-on-a-chip model of Mycobacterium fortuitum lung infection. Ektnitphong V, Dias BRS, Campos PC, Shiloh MU, Dis Model Mech 2025 Sep 18 9 Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells. Alvarez-Arguedas S, Mazhar K, Wangzhou A, Sankaranarayanan I, Gaona G, Lafin JT, Mitchell RB, Price TJ, Shiloh MU, Mucosal Immunol 2025 Jul Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis. Khan HS, Nair VR, Ruhl CR, Alvarez-Arguedas S, Galvan Rendiz JL, Franco LH, Huang L, Shaul PW, Kim J, Xie Y, Mitchell RB, Shiloh MU, Elife 2020 Mar 9 Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough. Ruhl CR, Pasko BL, Khan HS, Kindt LM, Stamm CE, Franco LH, Hsia CC, Zhou M, Davis CR, Qin T, Gautron L, Burton MD, Mejia GL, Naik DK, Dussor G, Price TJ, Shiloh MU, Cell 2020 Mar Pglyrp1-Cre marks distinct epithelial and immune lineages across mucosal sites. Alvarez-Arguedas S, Shiloh MU, Immunohorizons 2026 Jun 10 6 CMPK2 restricts Mycobacterium tuberculosis replication and regulates macrophage gene expression. Neff J, Ektnitphong VA, Campos PC, Naqvi KF, Dias BRS, Rahlwes KC, Zhong Z, Shiloh MU, bioRxiv 2026 May Results 1-10 of 42 1 2 3 4 5 Next Last Books Featured Books Infectious Diseases. In Hospitalist Handbook Marciano D, Shiloh MU, Newman M. (2002). San Francisco, University of California at San Francisco Antimicrobial Mechanisms of Macrophages. In Phagocytosis: The Host Shiloh, MU and Nathan, C (1999). Greenwich, CT, JAI Press Honors & Awards American Society of Clinical InvestigationMember (2021) Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases (2018-2023) The Department of Internal Medicine Chair's Pilot AwardsA Synthetic Lethal Genetic Interaction Map in Mycobacterium tuberculosis (2015-2017) UTSW High Impact/High Risk AwardResearch award for development of a novel M. tuberculosis vaccine (2012) Disease Oriented Clinical Scholar, UTSW (2011) NIH/NIAID K08 award2008-2012 (2008) Sandler Family Foundation Discovery AwardResearch award for highly innovative research (2006) Giannini Family Foundation Research Fellowship, 2005-2008Honors research fellows in the state of California (2005) Professional Associations/Affiliations American Association of Immunologists (2014) American Society of Clinical Investigation (2021) American Society of Microbiology (2013) Infectious Disease Society of America (2010)
