Denise Marciano earned her bachelor’s degree from Dartmouth College. She received her Ph.D. in Cellular Biophysics at the Rockefeller University and her M.D. at Cornell University. She completed the rest of her medical training at the University of California San Francisco, where she became drawn to caring for patients with kidney disease. At that time, she also developed a passion for research on how the kidney develops and functions. Lured by the opportunity to meld her clinical and scientific interests, she joined the faculty in Internal Medicine at UT Southwestern in 2011. She is also an attending physician at Parkland Memorial Hospital, where she sees patients with renal disease. Dr. Marciano’s interests outside of medicine and research include spending time with her family, hiking, and cooking.

The goal of Dr. Marciano’s research is to understand the cellular and molecular mechanisms that drive kidney development and repair after injury. She uses a variety of cellular, genetic, and biochemical approaches to study these processes in renal tubules and the filtration units of the kidney, called glomeruli. She has received several grant awards to support her research laboratory, including awards from the March of Dimes and the NIH. More details on her research program can be found at the Marciano Research Lab.


Graduate School
Rockefeller University (1999)
Other Post Graduate Training
Rockefeller University (1999)
Medical School
Cornell University Medical College (2001)
University of California, San Francisco (2004), Internal Medicine
University of California at San Francisco (2007), Nephrology

Research Interest

  • Cell polarity
  • Glomerular structure and function
  • Kidney development and disease
  • Tubulogenesis


Featured Publications LegendFeatured Publications

Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.
Faralla C, Bastounis EE, Ortega FE, Light SH, Rizzuto G, Gao L, Marciano DK, Nocadello S, Anderson WF, Robbins JR, Theriot JA, Bakardjiev AI PLoS Pathog. 2018 May 14 5 e1007094
Spatiotemporal heterogeneity and patterning of developing renal blood vessels.
Daniel E, Azizoglu DB, Ryan AR, Walji TA, Chaney CP, Sutton GI, Carroll TJ, Marciano DK, Cleaver O Angiogenesis 2018 Apr
Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection.
Nair VR, Franco LH, Zacharia VM, Khan HS, Stamm CE, You W, Marciano DK, Yagita H, Levine B, Shiloh MU Cell Rep 2016 Jul
Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection.
Scharn CR, Collins AC, Nair VR, Stamm CE, Marciano DK, Graviss EA, Shiloh MU J. Immunol. 2016 Jun 196 11 4641-9
Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients.
Nie M, Bal MS, Yang Z, Liu J, Rivera C, Wenzel A, Beck BB, Sakhaee K, Marciano DK, Wolf MT J. Am. Soc. Nephrol. 2016 Apr
Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production.
Zhu J, Chaki M, Lu D, Ren C, Wang SS, Rauhauser AA, Li B, Zimmerman S, Jun B, Du Y, Vadnagara K, Wang H, Elhadi S, Quigg RJ, Topham MK, Mohan C, Ozaltin F, Zhou XJ, Marciano DK, Bazan NG, Attanasio M Am. J. Physiol. Renal Physiol. 2016 Feb ajprenal.00431.2015
Cdc42 regulates epithelial cell polarity and cytoskeletal function in kidney tubule development.
Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R J. Cell. Sci. 2015 Oct
A novel method that improves sensitivity of protein detection in PAGE and western blot.
Vallejo-Illarramendi A, Marciano DK, Reichardt LF Electrophoresis 2013 Feb
cor, a Novel Carbon Monoxide Resistance Gene, Is Essential for Mycobacterium tuberculosis Pathogenesis.
Zacharia VM, Manzanillo PS, Nair VR, Marciano DK, Kinch LN, Grishin NV, Cox JS, Shiloh MU MBio 2013 4 6
The basement membrane of hair follicle stem cells is a muscle cell niche.
Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM Cell 2011 Feb 144 4 577-89

Honors & Awards

  • Elected to American Society of Clinical Investigation
  • Fellow of the American Society of Nephrology
  • March of Dimes Basil O'Connor Scholar
  • Norman S. Coplon Extramural Grant
  • K08 and NKF Young Investigator Awards
  • NRSA F32 grant
  • Janet M. Glasgow Memorial Achievement Award
    Graduated in top ten students at Cornell Univ Medical College (2001)
  • Magna cum laude and Phi Beta Kappa, Dartmouth College

Professional Associations/Affiliations

  • American Heart Association (2014)
  • American Society of Nephrology
  • National Kidney Foundation