Julie Mirpuri Hathiramani, M.D.

Julie Mirpuri Hathiramani, M.D., is an Associate Professor in the Department of Pediatrics, Division of Neonatal-Perinatal Medicine. Board certified in pediatrics and neonatal-perinatal medicine, she officially joined the UT Southwestern faculty in 2010.

A physician-scientist, Dr. Mirpuri focuses her research efforts on neonatal microbiome development with a goal of developing novel therapies to improve the health of babies.

She earned her medical degree at the University of Hong Kong. She completed her residency in pediatrics at Goryeb Children’s Hospital – Atlantic Health, followed by a fellowship in neonatal-perinatal medicine at Emory University School of Medicine/Grady Memorial Hospital.

Dr. Mirpuri, part of the UT Southwestern Pediatric Group, practices at UT Southwestern and Children’s Health.

Medical School

Univeristy of Hong Kong (2000)

Internship

Hospital Authority of Hong Kong (2001), Rotating

Residency

Goryeb Children's Hospital - Atlantic Health (2007), Pediatrics

Fellowship

Emory University School of Medicine/Grady Memorial Hospital (2010), Neonatal-perinatal Medicine

• Probiotics/Commensal organisms and their effects on immune mediators in the developing gut

Featured Publications

Maternal microbial factors that affect the fetus and subsequent offspring.

Mirpuri J, Neu J, Semin Perinatol 2021 10 45 6 151449

Traffic generated emissions alter the lung microbiota by promoting the expansion of Proteobacteria in C57Bl/6 mice placed on a high-fat diet.

Daniel S, Pusadkar V, McDonald J, Mirpuri J, Azad RK, Goven A, Lund AK, Ecotoxicol Environ Saf 2021 Apr 213 112035

The emerging role of group 3 innate lymphoid cells in the neonate: interaction with the maternal and neonatal microbiome.

Mirpuri J, Oxf Open Immunol 2021 2 1 iqab009

Exposure to diesel exhaust particles results in altered lung microbial profiles, associated with increased reactive oxygen species/reactive nitrogen species and inflammation, in C57Bl/6 wildtype mice on a high-fat diet.

Daniel S, Phillippi D, Schneider LJ, Nguyen KN, Mirpuri J, Lund AK, Part Fibre Toxicol 2021 01 18 1 3

Evidence for maternal diet-mediated effects on the offspring microbiome and immunity: implications for public health initiatives.

Mirpuri J, Pediatr Res 2021 01 89 2 301-306

Transient neonatal antibiotic exposure increases susceptibility to late-onset sepsis driven by microbiota-dependent suppression of type 3 innate lymphoid cells.

Niu X, Daniel S, Kumar D, Ding EY, Savani RC, Koh AY, Mirpuri J, Sci Rep 2020 07 10 1 12974

Maternal high-fat diet results in microbiota-dependent expansion of ILC3s in mice offspring.

Babu ST, Niu X, Raetz M, Savani RC, Hooper LV, Mirpuri J JCI Insight 2018 Oct 3 19

Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi.

Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F Cell 2016 Feb 164 5 827-8

The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.

Liao J, Kapadia VS, Brown LS, Cheong N, Longoria C, Mija D, Ramgopal M, Mirpuri J, McCurnin DC, Savani RC Nat Commun 2015 6 8977

Short-term outcomes for preterm infants with surgical necrotizing enterocolitis.

Murthy K, Yanowitz TD, DiGeronimo R, Dykes FD, Zaniletti I, Sharma J, Sullivan KM, Mirpuri J, Evans JR, Wadhawan R, Piazza A, Adams-Chapman I, Asselin JM, Short BL, Padula MA, Durand DJ, Pallotto EK, Reber KM, J Perinatol 2014 Oct 34 10 736-40

• FASEB Travel Scholarship
  (2011)
• Basic Science Young Investigator Award, Southern Society for Pediatric Research
  (2010)
• SPR Fellow Basic Science Research Award
  (2010)
• Trainee Travel Award, Southern Society for Pediatric Research
  (2009)
• Travel Grant, Pediatric Academic Societies
  (2009)

• American Academy of Pediatrics (2004)
• Medical Council of Hong Kong
• Southern Society for Pediatric Research (2007)
• The American Association of Immunologists (2013)