Ivan D'Orso, Ph.D. Professor School Medical School Department Microbiology Graduate Programs Biological Chemistry, Genetics, Development and Disease, Molecular Microbiology Biography Dr. D’Orso received his B.S. and Master in Biological Sciences, from the National University of Mar del Plata (Buenos Aires, Argentina) in 1998 and then obtained his Ph.D. in Biochemistry and Molecular Biology from the National University of Buenos Aires (Argentina) in 2003 under the tutelage of the U.S. National Academy Member Dr. Alberto C. Frasch. He continued his training as a post-doctoral fellow with Dr. Alan D. Frankel at the Department of Biochemistry and Biophysics at the University of California, San Francisco, during which time he was supported by fellowships from the Fundación Antorchas (Argentina), Human Frontier Science Program and amfAR. During his postdoctoral position, Dr. D’Orso elucidated key features about the mechanisms of HIV-1 transcriptional regulation. Following receipt of a NIH Pathway to Independence Award (K99/R00) from the NIAID in 2009, Dr. D’Orso began his independent career in November 2010. The major theme of his work is to characterize the mechanisms of transcriptional regulation during HIV-1 latency, immune cell fate choice, and cancer. He uses a wide-range of approaches (genetics, protein biochemistry, functional genomics and virology) to identify and characterize these molecular mechanisms. Dr. D’Orso’s research program has been supported by grants from the National Institutes of Health (NIAID, NCI), The Welch Foundation, American Cancer Society, CPRIT, The Campbell Foundation, and amfAR. Education Undergraduate Universidad Nacional De Mar De (1998), Biology Graduate School Universidad Nacional De San Ma (2003), Molecular Biology Research Interest Chromatin biology Epigenetics Gene dysregulation in cancer HIV cure HIV/AIDS Immune cell fate transitions Transcriptional regulation Viral latency Publications Featured Publications KAP1 negatively regulates RNA polymerase II elongation kinetics to activate signal-induced transcription Hyder U, Challa A, Thornton M, Nandu T, Krauss LW, D'Orso I Nature Commun 2024 The HIV-1 Transcriptional Program: From Initiation to Elongation Control D'Orso I J Mol Biol 2024 HIV-1 Proviral Genome Engineering with CRISPR-Cas9 for Mechanistic Studies Hyder U, Shukla A, Challa A, D'Orso I Viruses 2024 Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation Randolph K, Hyder U, Challa A, Perez E, D'Orso I Viruses 2024 Mathematical Models of HIV-1 Dynamics, Transcription, and Latency D'Orso I, Forst C Viruses 2024 ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss Wang J, Fendler NL, Shukla A, Wu S-Y, Challa A, Lee J, Joachimiak LA, Chiang C-M, Vos SM, D'Orso I Mol Cell 2024 ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Ramirez NP, Lee J, Zheng Y, Li L, Dennis B, Chen D, Challa A, Planelles V, Westover KD, Alto NM, D'Orso I, Nat Commun 2022 Mar 13 1 1109 The ARF tumor suppressor targets PPM1G/PP2C? to counteract NF-?B transcription tuning cell survival and the inflammatory response. Hyder U, McCann JL, Wang J, Fung V, Bayo J, D'Orso I, Proc Natl Acad Sci U S A 2020 Dec KAP1 Is a Chromatin Reader that Couples Steps of RNA Polymerase II Transcription to Sustain Oncogenic Programs. Bacon CW, Challa A, Hyder U, Shukla A, Borkar AN, Bayo J, Liu J, Wu SY, Chiang CM, Kutateladze TG, D'Orso I, Mol. Cell 2020 May An Integrated Genomics Approach Towards Deciphering Human Genome Codes Shaping HIV-1 Proviral Transcription and Fate Ruess H, Lee J, Guzman C, Malladi, D'Orso I BioRxiv 2020 Results 1-10 of 35 1 2 3 4 Next Last Honors & Awards NIDA DP1 Avant-Garde Award Program for HIV Research (Finalist) (2023-2024) The Campbell Foundation for HIV/AIDS Research (2022-2023) American Cancer Society (ACS) (2013-2016) The Welch Foundation (2012-2015) NIH/NIAID K99/R00 Pathway to Independence Award, USA (2009) amfAR Postdoctoral FellowInaugural Mathilde Krim Fellowship to support bright young scientist for AIDS Research (2008) Human Frontier Science Program (HFSP) Postdoctoral Fellow (2004-2008) Sixth Young Talent Prize - Amersham-Pharmacia, Brazil (2002) Research in Health Science prize, Argentina (2000) Professional Associations/Affiliations Affiliated Member, The Cecil H. and Ida Green Center for Reproductive Biology Sciences (2021-2024) Professor, Department of Microbiology (2011-2024)
