John M. Dietschy, M.D., is the H. Ben and Isabelle T. Decherd Chair in Internal Medicine in Honor of Henry M. Winans, Sr., M.D., in the Department of Internal Medicine. Dr. Dietschy received his medical degree from Washington University School of Medicine in Saint Louis, Missouri. He completed his internship and residency training in internal medicine in Denver, Colorado. Subsequently, Dr. Dietschy served as a postdoctoral research fellow in gastroenterology at Boston University School of Medicine at Massachusetts Memorial Hospital and then had additional training in lipid biochemistry and metabolism as a research fellow at the University of Texas Southwestern Medical Center at Dallas. He has been on the faculty of the Department of Internal Medicine at UT Southwestern since 1965. He served as chief of the Division of Gastroenterology from 1979 to 1998 and as chief of the Division of Digestive and Liver Diseases from 1999-2002. His research has generally been in the area of regulation of cholesterol absorption and sterol metabolism. His recent research interests have involved the mechanism of action of a number of different ABC transporters on moving cholesterol across membranes, in newer pathways for bile acid synthesis and in understanding the mechanisms of regulation of cholesterol balance across the brain. He has authored more than 200 research publications in various professional journals including the Journal of Biological Chemistry, Science, Neuroscience, Current Opinion in Lipidology and the Journal of Lipid Research.


University of Washington (1954)
Medical School
University of Washington (1958)

Research Interest

  • Cholesterol metabolism
  • Heart disease
  • Lipoprotein metabolism
  • Malabsorption
  • Neurodegeneration


Featured Publications LegendFeatured Publications

Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein
Xie C, Richardson JA, Turley SD, Dietschy JD J. Lipid Res. 2006 47 953-963
Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse
Garver, W.S., Xie, C., Repa, J.J., Turley, S.D., Dietschy, J,M. J. Lipid Res. 2005 46 1745-1754
Cholesterol accumulation and liver cell death in the mouse with Niemann-Pick type C disease.
Beltroy, E.P., Richardson, J.A., Horton, J.D., Turley, S.D., Dietschy, J.M. Hepatology 2005 42 886-893
Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption
Repa, J.J., Turley, S.D., Quan, G. and Dietschy, J.M. J. Lipid Res. 2005 46 779-789
Molecular, anatomical and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease
Li, H., Repa, J.J., Valasek, M.A., Beltroy, E., Turley, S.D., German, D.C. and Dietschy, J.M. J. Neuropathol. Exp. Neurol. 2005 64 323-333

Honors & Awards

  • Janssen Award in Gastroenterology
    Lifetime Achievement in Digestive Sciences (2001)
  • MERIT Award
    National Institutes of Health (1995)
  • President
    American Gastroenterological Association (1987)
  • McKenna Medal
    Canadian Association of Gastroenterology (1985)
  • Heinrich-Wieland Prize in Lipid Biochemistry
    University of Munich, Germany (1983)

Professional Associations/Affiliations

  • American Association for the Advancement of Science
  • American Federation for Clinical Research
  • American Gastroenterological Association
  • American Society for Clinical Investigation
  • Association for American Physicians