Amit Singal, M.D.

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Amit Singal, M.D., M.S., is a Professor in the Department of Internal Medicine at UT Southwestern Medical Center, and a member of its Division of Digestive & Liver Diseases. He is an expert in hepatocellular carcinoma and serves as the Medical Director of the UT Southwestern Liver Tumor Program. He also is a Dedman Family Scholar in Clinical Care and holds the Willis C. Maddrey, M.D. Distinguished Chair in Liver Disease.

Dr. Singal earned his medical degree at the University of Michigan. He completed a residency in internal medicine at the University of Washington and then received advanced training in gastroenterology and transplant hepatology through separate fellowships at the University of Michigan. He also holds master’s degrees in health and health care research and in clinical science with distinction from the University of Michigan.

Certified by the American Board of Internal Medicine in gastroenterology and transplant hepatology, he joined the UT Southwestern faculty in 2010.

Dr. Singal’s research focuses on diagnosing and treating liver cancer before it becomes incurable. He has received numerous grants, including from the National Institutes of Health (NIH), CPRIT, and the Department of Defense, examining the HCC care continuum, ranging from HCC prevention to screening and early detection to treatment and survivorship, and he lectures on his work frequently throughout the world.

He has published more than 200 articles in many peer-reviewed publications, such as JAMA, Gastroenterology, Hepatology, Journal of Hepatology, and GUT. In addition, he is an associate editor for both Clinical Gastroenterology and Hepatology and Seminars in Liver Disease.

Dr. Singal has received Investigator Awards from the International Liver Cancer Association and the American Gastroenterological Association, and he recently received the Blue Faery Award for Excellence in Liver Cancer Research by a liver cancer patient advocacy group.

He is a member of multiple professional organizations, including the American Gastroenterological Association, the American College of Gastroenterology, and the American Association for the Study of Liver Diseases. For the latter, he served as Vice Chair of the Practice Guidelines Committee, and currently he serves on the International Liver Cancer Association’s Executive Committee.

In 2018, he was named a Super Doctor by Texas Monthly.

Personal Note

During his time off, Dr. Singal likes to travel internationally. And he loves to cheer on his home teams – the Michigan Wolverines, Detroit Lions, and Detroit Red Wings – when they are in Dallas.

Medical School

University of Michigan Medical School (2003)

Residency

University of Washington School of Medicine (2006), Internal Medicine

Fellowship

University of Michigan Medical Center (2009), Gastroenterology

Fellowship

University of Michigan Medical Center (2010), Transplant Hepatology

• Effectiveness of surveillance for hepatocellular carcinoma
• Impact of patient and physician knowledge/attitudes on receipt of care
• Quality of care in the cirrhotic patient

Featured Publications

Hepatocellular carcinoma demonstrates heterogeneous growth patterns in a multi-center cohort of patients with cirrhosis.

Rich NE, John BV, Parikh ND, Rowe I, Mehta N, Khatri G, Thomas SM, Anis M, Mendiratta-Lala M, Hernandez C, Odewole M, Sundaram LT, Konjeti VR, Shetty S, Shah T, Zhu H, Yopp AC, Hoshida Y, Yao FY, Marrero JA, Singal AG, Hepatology 2020 Feb

Direct-Acting Antiviral Therapy for HCV Infection is Associated with Increased Survival in Patients With a History of Hepatocellular Carcinoma.

Singal AG, Rich NE, Mehta N, Branch A, Pillai A, Hoteit M, Volk M, Odewole M, Scaglione S, Guy J, Said A, Feld JJ, John BV, Frenette C, Mantry P, Rangnekar AS, Oloruntoba O, Leise M, Jou JH, Bhamidimarri KR, Kulik L, Ioannou GN, Huang A, Tran T, Samant H, Dhanasekaran R, Duarte-Rojo A, Salgia R, Eswaran S, Jalal P, Flores A, Satapathy SK, Kagan S, Gopal P, Wong R, Parikh ND, Murphy CC, Gastroenterology 2019 Jul

Evaluation of a multifaceted intervention to reduce health disparities in hepatitis C screening: a pre-post analysis.

Jain MK, Rich NE, Ahn C, Turner BJ, Sanders JM, Adamson B, Quirk L, Perryman P, Santini NO, Singal AG, Hepatology 2019 Apr

Direct-Acting Antiviral Therapy not Associated with Recurrence of Hepatocellular Carcinoma in a Multicenter North American Cohort Study.

Singal AG, Rich NE, Mehta N, Branch A, Pillai A, Hoteit M, Volk M, Odewole M, Scaglione S, Guy J, Said A, Feld JJ, John BV, Frenette C, Mantry P, Rangnekar AS, Oloruntoba O, Leise M, Jou JH, Bhamidimarri KR, Kulik L, Tran T, Samant H, Dhanasekaran R, Duarte-Rojo A, Salgia R, Eswaran S, Jalal P, Flores A, Satapathy SK, Wong R, Huang A, Misra S, Schwartz M, Mitrani R, Nakka S, Noureddine W, Ho C, Konjeti VR, Dao A, Nelson K, Delarosa K, Rahim U, Mavuram M, Xie JJ, Murphy CC, Parikh ND Gastroenterology 2019 Jan

Hepatocellular Carcinoma Screening Is Associated With Increased Survival of Patients With Cirrhosis.

Choi DT, Kum HC, Park S, Ohsfeldt RL, Shen Y, Parikh ND, Singal AG Clin. Gastroenterol. Hepatol. 2018 Oct

Mailed Outreach Invitations Significantly Improve HCC Surveillance Rates in Patients with Cirrhosis: A Randomized Clinical Trial.

Singal AG, Tiro JA, Murphy CC, Marrero JA, McCallister K, Fullington H, Mejias C, Waljee AK, Pechero Bishop W, Santini NO, Halm EA Hepatology 2018 Aug

Primary Care Provider Practice Patterns and Barriers to Hepatocellular Carcinoma Surveillance.

Simmons OL, Feng Y, Parikh ND, Singal AG Clin. Gastroenterol. Hepatol. 2018 Jul

Racial and Ethnic Differences in Presentation and Outcomes of Hepatocellular Carcinoma.

Rich NE, Hester C, Odewole M, Murphy CC, Parikh ND, Marrero JA, Yopp AC, Singal AG Clin. Gastroenterol. Hepatol. 2018 May

Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis.

Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, Waljee A, Singal AG Gastroenterology 2018 Feb

Effect of Colonoscopy Outreach vs Fecal Immunochemical Test Outreach on Colorectal Cancer Screening Completion: A Randomized Clinical Trial.

Singal AG, Gupta S, Skinner CS, Ahn C, Santini NO, Agrawal D, Mayorga CA, Murphy C, Tiro JA, McCallister K, Sanders JM, Bishop WP, Loewen AC, Halm EA JAMA 2017 09 318 9 806-815

• D Magazine Best Doctors
  (2021)
• UT Southwestern Internal Medicine Outstanding Research Mentor
  (2021)
• D Magazine Best Doctors
  (2020)
• UT Southwestern Internal Medicine Outstanding Research Mentor
  (2020)
• UT Southwestern Center for Translational Medicine Outstanding Mentor Award
  (2019)
• UT Southwestern Internal Medicine Outstanding Research Mentor
  (2018)
• Blue Faery Award for Excellence in Liver Cancer Research
  (2017)
• International Liver Cancer Association Junior Investigator Award
  (2013)
• Lyman Bilhartz Memorial Teaching Award
  (2012)
• Super Doctors Rising Stars
  (2012)
• Dedman Family Scholar in Clinical Care
  (2010)
• AASLD Advanced Transplant Hepatology Fellowship Award
  (2009)
• Phi Kappa Phi National Honor Society
  (2008)
• Huesby Teaching Award
  (2006)
• Alpha Omega Alpha Medical Honors Society
  (2002)

• American Association for the Study of Liver Diseases (2006)
• American College of Gastroenterology (2006)
• International Liver Cancer Association (2007)